DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dok and Dok1

DIOPT Version :9

Sequence 1:	NP_572391.1	Gene:	Dok / 31667	FlyBaseID:	FBgn0029944	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001020587.1	Gene:	Dok1 / 312477	RGDID:	1309499	Length:	480	Species:	Rattus norvegicus

Alignment Length:	315	Identity:	85/315 - (26%)
Similarity:	132/315 - (41%)	Gaps:	74/315 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RISKKKACSRYCLLFKASRHGIARLEMCESKEDRNP-----------KIFTLENCVK---ITQEP 74
            |...|:....:.:|:.||.||:||||..:.|...:.           |:..|..||.   :|.|.
  Rat    16 RFGTKRWKKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGGSRRLDCKMIRLAECVSVVPVTVES 80

  Fly    75 PPE------RLIHIVKRQATLTLSTSSEEELKDWITALQTVAFCDTSPSGG-----------IGA 122
            |||      || ...:|...|....:|...   |:..|...||    |.||           ..|
  Rat    81 PPEPGASAFRL-DTAQRSHLLAADAASSTA---WVQILCRTAF----PKGGWALAQTENPPKFSA 137

  Fly   123 IEE-DNDLYCSSFDG-LFIITLIPSEASIRCCIEPKTYMLQMTPTELQLKSEDLGA------TIA 179
            :|. :|.||..:::| .|.:|...:|||.||.:: .:|:|::...:|.|.:  |||      .:.
  Rat   138 LEMLENSLYSPTWEGSQFWVTSQKTEASERCGLQ-GSYVLRVEAEKLTLLT--LGAQSQILEPLL 199

  Fly   180 MWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFRCMSAKMKSMK---KLISGDSL 241
            .|||..:|:||.....|:|||||:|.:|.|.||.......::|:.:.|.::..|   |:..|..:
  Rat   200 FWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVEAAIQQQKAQGKVGQGQDI 264

  Fly   242 STLECGENQFSAAAGMEPGSRSPL----------------PPSPS-----SNPHG 275
            :..:..:.:........|..:.||                ||.||     |:|.|
  Rat   265 TRTDSHDGETEGKMAPTPVPQEPLGSPPALYAEPLDSLRIPPGPSQDSLYSDPLG 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..110	CDD:214574	28/105 (27%)
		PH	6..107	CDD:278594	27/102 (26%)
		PH-like	138..232	CDD:302622	33/99 (33%)
Dok1	NP_001020587.1	PH-like	6..119	CDD:418428	28/106 (26%)
		PTB_DOK1_DOK2_DOK3	151..253	CDD:269914	34/104 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..328		13/67 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335311
Domainoid	1	1.000	64	1.000	Domainoid score	I9887
eggNOG	1	0.900	-	-		E1_KOG4047
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46340
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21258
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1028
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.800