Protein Alignment Dok and Dok2

DIOPT Version :10

• Sequence 1: NP_572391.1
• Gene: Dok / 31667
• FlyBaseID: FBgn0029944
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001388203.1
• Gene: Dok2 / 290361
• RGDID: 1310966
• Length: 454
• Species: Rattus norvegicus
• Alignment Length: 439
• Identity: 111/439 - (25%)
• Similarity: 172/439 - (39%)
• Gaps: 119/439 - (27%)

  Fly    36 LLFKASRHGIARLEMCESKE-----DRNPKIFTLENCVKITQ-----EPPPERLIHIVKRQATLT 90
            :|:..|...:||||:.:..|     :...|:..|.:|:::.:     ..|.:....|::.:..|.
  Rat    74 VLYGESGCALARLELQDGPEKTRRGEATRKVVRLSDCLRVAEVGSEASSPRDTSAFILETKERLY 138

  Fly    91 LSTSSEEELKDWITALQTVAF---CDTSP----SGGIGAIEEDNDLYCSSFDGL---FIITLIPS 145
            |..:...|..|||.|:..:||   ...||    ..|...:|| |:||.||..|:   :.:|:.|:
  Rat   139 LLAAPSTERSDWIQAICLLAFPGQRKESPGLEEKNGSPCMEE-NELYSSSTTGVCKEYAVTIRPT 202

  Fly   146 EASIRCCIEPKTYMLQMTPTELQL-KSEDLGATIAMWPYRFIRKYGYRDGKFTFEAGRKCTTGEG 209
            |||.||.:. .:|.|:...:.|:| ...:.|..:..|||||:|::|.....|:|||||:|.:|||
  Rat   203 EASERCRLR-GSYTLRTGVSALELWGGPEPGTQLYDWPYRFLRRFGRDKVTFSFEAGRRCVSGEG 266

  Fly   210 VFTLDHTNPQEVFRCMSAKMKSMKKLISGDSLSTLECGENQFSAAAGMEPGSRSPLPPSPSSNPH 274
            .|..:.....|:|       ::::|.|:....:| ..|.....|...|.| :..|.|.||.|.||
  Rat   267 SFEFETRQGNEIF-------QALEKAIAAQKNAT-PSGPPTLPATGSMMP-TALPRPESPYSRPH 322

  Fly   275 GGEFEINSTQSCISLRGFISSNDSLNNFSAG-------GGGASGATATGGGVLGSTGGITLSVPA 332
                                  |||.:.|.|       .||:.|..|               ||.
  Rat   323 ----------------------DSLPSPSPGTPVPGIRSGGSEGEYA---------------VPF 350

  Fly   333 NS--NSNSSSSKHIPNKPPRKSPTTHCDKYRNIVKYEPVAITTISSPSANSDVNSSVILKPLEGE 395
            ::  :|...|.:.|...||...|    |...:.::.:||.                    ||...
  Rat   351 DTVVHSLKKSFRGILTGPPPLLP----DPLYDSIQEDPVV--------------------PLPDH 391

  Fly   396 SISLPETAADLPPDLPLRNESASKAPPPERDYECIENITEAWRTRGVGD 444
            ....||..|.|  .|..|::..|               .|.||.:...|
  Rat   392 IYDEPEGVAAL--SLYERSQKPS---------------GETWREQATAD 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..107	CDD:459697	19/80 (24%)
		IRS	138..233	CDD:460473	32/95 (34%)
Dok2	NP_001388203.1	PH-like	53..159	CDD:473070	19/84 (23%)
		PTB_DOK1_DOK2_DOK3	192..290	CDD:269914	34/105 (32%)