Protein Alignment Dok and Dok3

DIOPT Version :10

• Sequence 1: NP_572391.1
• Gene: Dok / 31667
• FlyBaseID: FBgn0029944
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_038767.1
• Gene: Dok3 / 27261
• MGIID: 1351490
• Length: 444
• Species: Mus musculus
• Alignment Length: 461
• Identity: 105/461 - (22%)
• Similarity: 169/461 - (36%)
• Gaps: 130/461 - (28%)

  Fly     3 VEIPVLAGYLNVPTQTGFSLNRISKKKACSR--YCLLFKASRHGIARLEMCESKE-------DRN 58
            ||.||..|.|        ....:...|.|.|  :.||:.....|:||||..:.::       ||:
Mouse     4 VEPPVKDGIL--------YQQHVKFGKKCWRKVWALLYAGGPSGVARLESWDVRDGGLGPAGDRS 60

  Fly    59 P--------KIFTLENCVKITQ---EPPPERLIHIVKRQATLTLSTSSE-------EELKDWITA 105
            .        ::..|.:||.:..   |..|        |.....|.|::|       :..:.|:..
Mouse    61 TGPSRRGERRVIRLADCVSVLPADGESCP--------RDTGAFLITTTERSHLLAAQHRQSWVDP 117

  Fly   106 LQTVAFCDTSP-SGGIGAIE---------EDNDLYCSSFDGL--FIITLIPSEASIRCCIEPKTY 158
            :..:||..|.. |.|.|..|         |:|.:| ||:..:  |.:.:..:||:.||.:: ..|
Mouse   118 ICQLAFPGTGECSSGSGQAESPKRGFVPMEENSIY-SSWQEVTEFPVIVQRTEATSRCQLK-GPY 180

  Fly   159 MLQMTPTELQLKSEDLGATIAMWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFR 223
            :|.:...::||:..........|||||:||||...|.|:|||||:|.:|||:|........::..
Mouse   181 LLVLGQDDIQLRETSKPQACFSWPYRFLRKYGSDKGVFSFEAGRRCDSGEGLFAFSSPRAPDICG 245

  Fly   224 CMSAKMKSMKK------------LISGDSLSTLECGENQFSAAAGMEPGSRSPLP---PSPSSNP 273
            .::|.:...::            |....||.:||........|.|.|..:...||   |.|.|.|
Mouse   246 VVAAAIARQRERLPELAMSPPCPLPRALSLPSLEPPGELREVAPGFELPTPRKLPLTDPGPQSLP 310

  Fly   274 HGGEFEINSTQSCISLRGFISSNDSLNNFSAGGGGASGATATGGGVLGSTGGITLSVPANSNSNS 338
                ..::.||.                                   |...|:..||...::.::
Mouse   311 ----LLLSPTQE-----------------------------------GPASGLYASVCKQTSKHT 336

  Fly   339 SSSKHIPNKPPRKSPTTHCDKYRNIVKYEPVAITTISSPSANSDV--NSSVILKPL--EGESISL 399
            .:::|:               |.|:...|.....|...|.|....  ..|.:..|:  ..|.:|.
Mouse   337 GTAEHL---------------YENVCMLEASPGLTNGGPEAQEGPPGGRSPLGSPIYHNTEDLSW 386

  Fly   400 PETAAD 405
            |.:|.|
Mouse   387 PGSAQD 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..107	CDD:459697	26/127 (20%)
		IRS	138..233	CDD:460473	31/94 (33%)
Dok3	NP_038767.1	PH_DOK1,2,3	9..123	CDD:270195	24/129 (19%)
		PTB_DOK1_DOK2_DOK3	157..255	CDD:269914	31/98 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	278..299		5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..390		8/35 (23%)