DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dok and DOK1

DIOPT Version :9

Sequence 1:	NP_572391.1	Gene:	Dok / 31667	FlyBaseID:	FBgn0029944	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001372.1	Gene:	DOK1 / 1796	HGNCID:	2990	Length:	481	Species:	Homo sapiens

Alignment Length:	475	Identity:	114/475 - (24%)
Similarity:	178/475 - (37%)	Gaps:	133/475 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLAGYLNVPTQTGFSLNRISKKKACSRYCLLFKASRHGIARLEMCESKEDRNP-----------K 60
            |:.|.|.:.:|      |...|:....:.:|:.||.||:||||..:.|...:.           |
Human     5 VMEGPLFLQSQ------RFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCK 63

  Fly    61 IFTLENCVK---ITQEPPPE------RLIHIVKRQATLTLSTSSEEELKDWITAL---------Q 107
            :..|..||.   :|.|.|||      || ...:|...|.....|...   |:..|         .
Human    64 VIRLAECVSVAPVTVETPPEPGATAFRL-DTAQRSHLLAADAPSSAA---WVQTLCRNAFPKGSW 124

  Fly   108 TVAFCDTSPSGGIGAIEE-DNDLYCSSFDG-LFIITLIPSEASIRCCIEPKTYMLQMTPTELQLK 170
            |:|..|..|.  :.|:|. :|.||..:::| .|.:|:..:||:.||.:. .:|:|::....|.|.
Human   125 TLAPTDNPPK--LSALEMLENSLYSPTWEGSQFWVTVQRTEAAERCGLH-GSYVLRVEAERLTLL 186

  Fly   171 SEDLGA------TIAMWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFRCMSA-- 227
            :  :||      .:..|||..:|:||.....|:|||||:|.:|.|.||.......::|:.:..
Human   187 T--VGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAI 249

  Fly   228 -KMKSMKKLISGDSLSTLECGENQFSAAAGMEPGSRSPLPPSPSSNPHGGEFEINSTQSCI---- 287
             :.|:..|  :|.....|....::...|.|     :.|.||.|.        |:..:...:
Human   250 HRQKAQGK--AGQGHDVLRADSHEGEVAEG-----KLPSPPGPQ--------ELLDSPPALYAEP 299

  Fly   288 --SLR-GFISSNDSLNNFSAGGGGASGATATGGGVLGSTGGITLSVPANSNSNSSSSKHIPNKPP 349
              ||| ....|.|||                            .|.|.:|.| :.:.:.:..|.|
Human   300 LDSLRIAPCPSQDSL----------------------------YSDPLDSTS-AQAGEGVQRKKP 335

  Fly   350 RKSPTTHCDKYRNIVKYEPVAITTISSPSANSDVNSSVILKPLEGESISLPETAADLPP----DL 410
                 .:.|.|.:                |...:..:.:..|.|......||..|.:||    ||
Human   336 -----LYWDLYEH----------------AQQQLLKAKLTDPKEDPIYDEPEGLAPVPPQGLYDL 379

  Fly   411 PLRNESA--SKAPPPERDYE 428
            |...:.|  .:|...|..||
Human   380 PREPKDAWWCQARVKEEGYE 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..110	CDD:214574	33/131 (25%)
		PH	6..107	CDD:278594	32/128 (25%)
		PH-like	138..232	CDD:302622	31/102 (30%)
DOK1	NP_001372.1	PH-like	6..119	CDD:327399	31/122 (25%)
		PTB_DOK1_DOK2_DOK3	151..253	CDD:269914	31/104 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..293		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..329		8/50 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141621
Domainoid	1	1.000	64	1.000	Domainoid score	I10117
eggNOG	1	0.900	-	-		E1_KOG4047
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42191
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21258
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5513
SonicParanoid	1	1.000	-	-		X1028
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.830