DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dok and Dok1

DIOPT Version :9

Sequence 1:	NP_572391.1	Gene:	Dok / 31667	FlyBaseID:	FBgn0029944	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_034200.4	Gene:	Dok1 / 13448	MGIID:	893587	Length:	482	Species:	Mus musculus

Alignment Length:	548	Identity:	128/548 - (23%)
Similarity:	201/548 - (36%)	Gaps:	169/548 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLAGYLNVPTQTGFSLNRISKKKACSRYCLLFKASRHGIARLEMCESKEDRNP-----------K 60
            |:.|.|.:.:|      |...|:....:.:|:.||.||:||||..:.|...:.           |
Mouse     5 VMEGPLFLQSQ------RFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSRGGRGGSRRLDCK 63

  Fly    61 IFTLENCVK---ITQEPPPE------RL-----IHIVKRQATLTLSTSSEEELKDWITALQTVAF 111
            :..|..||.   :|.|.|||      ||     .|::...|..:.:         |:..|...||
Mouse    64 MIRLAECVSVVPVTVESPPEPGAVAFRLDTAQRSHLLAADAVSSTA---------WVQTLCRTAF 119

  Fly   112 CDTSPSGG-----------IGAIEE-DNDLYCSSFDG-LFIITLIPSEASIRCCIEPKTYMLQMT 163
                |.||           ..|:|. :|.||..:::| .|.:|...:|||.||.:: .:|:|::.
Mouse   120 ----PKGGWALAQTENQPKFSALEMLENSLYSPTWEGSQFWVTSQKTEASERCGLQ-GSYILRVE 179

  Fly   164 PTELQLKSEDLGA------TIAMWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVF 222
            ..:|.|.:  |||      .:..|||..:|:||.....|:|||||:|.:|.|.||...:...::|
Mouse   180 AEKLTLLT--LGAQSQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTSQGNDIF 242

  Fly   223 RCMSAKMKSMK---KLISGDSLSTLECGENQFSAAAGMEPGSRSPL--PPSPSSNPHGGEFEINS 282
            :.:.|.::..|   |:.....:...:..:.:........|..:.||  ||:..:.|
Mouse   243 QAVEAAIQQQKAQGKVGQAQDILRTDSHDGETEGKTVPPPVPQDPLGSPPALYAEP--------- 298

  Fly   283 TQSCISLR---GFISSNDSLNNFSAGGGGASGATATGGGVLGSTGGITLSVPANSNSNSSSSKHI 344
               ..|||   |  .|.||:.:                ..||||       ||.:.....|.|.:
Mouse   299 ---LDSLRIPPG--PSQDSVYS----------------DPLGST-------PAGAGEGVHSKKPL 335

  Fly   345 PNKPPRKSPTTHCDKYRNIVKYEPVAITTISSPSANSDVNSSVILKPLEGESISLPETAADLPP- 408
                       :.|.|.::  .:.:..|.:      :|.....|....||.:.:.|....|||.
Mouse   336 -----------YWDLYGHV--QQQLLKTKL------TDSKEDPIYDEPEGLAPAPPRGLYDLPQE 381

  Fly   409 ----------------DLPLRNESASKAPPPERDYECIEN-------ITEAWRTRGVGDVRHSER 450
                            :||....:...|.||.|..:....       :.|:..|||.|....|.
Mouse   382 PRDAWWCQARLKEEGYELPYNPATDDYAVPPPRSPKPAPAPKPQGLILPESGTTRGSGSKGFSS- 445

  Fly   451 MPILCDTSEFVRQRSVSKS------TCG 472
                 ||:.:   ..|.||      .||
Mouse   446 -----DTALY---SQVQKSGTSGAWDCG 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..110	CDD:214574	31/127 (24%)
		PH	6..107	CDD:278594	30/124 (24%)
		PH-like	138..232	CDD:302622	33/99 (33%)
Dok1	NP_034200.4	PH	5..116	CDD:278594	31/125 (25%)
		PH-like	6..119	CDD:302622	30/127 (24%)
		PTB_DOK1_DOK2_DOK3	151..253	CDD:269914	34/104 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..328		19/95 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..373		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..482		19/77 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831568
Domainoid	1	1.000	64	1.000	Domainoid score	I10083
eggNOG	1	0.900	-	-		E1_KOG4047
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44242
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21258
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5513
SonicParanoid	1	1.000	-	-		X1028
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.830