Protein Alignment Dok and FRS2

DIOPT Version :9

• Sequence 1: NP_572391.1
• Gene: Dok / 31667
• FlyBaseID: FBgn0029944
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001036020.1
• Gene: FRS2 / 10818
• HGNCID: 16971
• Length: 508
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 96/512 - (18%)
• Similarity: 174/512 - (33%)
• Gaps: 163/512 - (31%)

  Fly   159 MLQMTPTELQLKSEDLGATIAMWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFR 223
            ::::|.|||.|.:....:  ..|.|..:|:|||....|:||:||:|.||:|:|.......:|:|
Human    37 IMELTDTELILYTRKRDS--VKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELF- 98

  Fly   224 CMSAKMKSMKKLISGDSLSTLECGENQFSAAAGMEPGSRSPLPPSPSSNPHGGEFEINSTQSCIS 288
                  ..:::::..:|::.:|                    .|....|.|..|.|:..|....:
Human    99 ------NMLQEIMQNNSINVVE--------------------EPVVERNNHQTELEVPRTPRTPT 137

  Fly   289 LRGFISSN--DSLNNFSAGGGGASGAT----ATGGGVLGSTG---------------------GI 326
            ..||.:.|  :....:.:.|..:|..:    :.|...|.|.|                     |:
Human   138 TPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGV 202

  Fly   327 --------TLSVPAN---SNSNSSSSKHIPNKPPRKSPTTHCDKYRNIVKYEPVAITTISSPS-A 379
                    ::.||..   ||:.||:.|..|:....:.|.         :..||..:..:..|: .
Human   203 QEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQ---------ILLEPEGVKFVLGPTPV 258

  Fly   380 NSDVNSSVILKPLEGESISLPETAADLPPDLPLRNESASKAPPPER-DYECIENITEAWRTRGVG 443
            ...:.....|:.|..:.:| ...|.:...|....::....||...: .||.|..::
Human   259 QKQLMEKEKLEQLGRDQVS-GSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLS--------- 313

  Fly   444 DVRHSERMPILCDTSEFVRQRSVSKSTCGSQNTPKIIDIDIGEGCTSATSISESNYDRLDFLSPN 508
                      :...|...|.|..|.||..:||        |.......|::  .||:.|..|
Human   314 ----------IPSASGVRRGRLTSTSTSDTQN--------INNSAQRRTAL--LNYENLPSL--- 355

  Fly   509 NKTSSGYKTIVNVTPGNRIRCSPPPPNEYELIASPDTESFRKADDSHRGYGVLRKASTTTNNNNL 573
                                   ||..|...::..:.::......|..||           :|||
Human   356 -----------------------PPVWEARKLSRDEDDNLGPKTPSLNGY-----------HNNL 386

  Fly   574 GISNSNISGGSSTITTATANK--------------GGNLEAAAIDHRSYNGLNYTMV 616
            ...::.::..:.|: .|:|:|              ..::...:::||.   |||..|
Human   387 DPMHNYVNTENVTV-PASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQ---LNYIQV 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..110	CDD:214574
		PH	6..107	CDD:278594
		PH-like	138..232	CDD:302622	23/72 (32%)
FRS2	NP_001036020.1	PTB_FRS2	15..106	CDD:269913	23/77 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	122..180		12/57 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..243		10/51 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	270..297		4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..338		9/30 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	366..385		3/29 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..467
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	483..508

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141617
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4047
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830