Protein Alignment Dok and dok3

DIOPT Version :10

• Sequence 1: NP_572391.1
• Gene: Dok / 31667
• FlyBaseID: FBgn0029944
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: XP_002664535.3
• Gene: dok3 / 100333972
• ZFINID: ZDB-GENE-101006-7
• Length: 533
• Species: Danio rerio
• Alignment Length: 504
• Identity: 104/504 - (20%)
• Similarity: 173/504 - (34%)
• Gaps: 143/504 - (28%)

  Fly    24 RISKKKACSRYCLLFKASRHGIARLEMCESKED----------------RNPKIFTLENCVKITQ 72
            :..||.....:.:|.:|...|::|||:.:.::.                .:.::..|.:|:.||.
Zfish    16 KFGKKIWRKSWLVLLEAGPAGVSRLELWDLRDGGGRMGFGISRPAGFKRTDKRVIRLSDCLSITP 80

  Fly    73 EP----PPE-RLIHIVKRQATLTLSTSSEEELKDWITALQTVAFCDTSPSGGIGAIEE------- 125
            .|    |.: ....:.....|.|::....:   ||:|.|..:||..:..|.....:::
Zfish    81 APAESCPTDCSAFFLNTTSCTFTIAAPQRD---DWLTVLCRLAFQKSRSSEDSRRVQKDKYLPLA 142

  Fly   126 DNDLYCSSFDGLFIITLIPSEASIRCCIEPKTYMLQMTPTELQLKSEDLGATIAMWPYRFIRKYG 190
            ||:||.:...|.|.:.:..:|:|.|..:. ..|:|......:.|.....|..|..||||.:|::|
Zfish   143 DNELYSTWGTGQFQVCVQSTESSQRLRLS-GYYLLSADKETVSLLDLRTGEPIQRWPYRLLRRFG 206

  Fly   191 YRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFRCMSAKM--KSMKKLISGDSLSTLE---CGENQ 250
            ...|....||||:|.:|||.|........::.|.:...:  :|:::|::..|....|   ..|..
Zfish   207 PVKGGIMIEAGRRCPSGEGQFIFQSKQGSQIHRAIEDAIMHQSVQELLAQASAIPQEPKNRPEVS 271

  Fly   251 FSAAAGMEPGSR---------------------------------------SPLPPSPSSNPHGG 276
            ...|...||.:|                                       :|.|| ||..|...
Zfish   272 KPPAIPQEPQNRPEISKPPEVTVNPQRPAIHCKRGQQIHKAIKEALALPSYTPQPP-PSPKPKAQ 335

  Fly   277 EFEINSTQSCISLRGFISSNDSLNNFSAGGGGASGATATGGGVLGSTGGITLSVPANSNSNSSSS 341
            ..|:...:.|..:|                                        |.|...|:...
Zfish   336 VKEVKREKPCPPVR----------------------------------------PINKYHNTQKL 360

  Fly   342 KHIPNKPPRKSPTTHCDKYRNIVKY------------EPVAI-TTISSPSANSDVNSSVIL---K 390
            ...|..||...|......:.|::|.            .|..| :::|||   .||..|||.   |
Zfish   361 TPPPPPPPPPLPKNRPPDWTNVLKNTDDPRRNISLPDPPACIRSSVSSP---DDVLYSVIFPQAK 422

  Fly   391 PLEGESISLPETAADLPPDLPLRNESASKAPPPERDYECIENITEAWRT 439
            |  .|.|:||     .||.:....|..|:....|.:.....|::...|:
Zfish   423 P--REVINLP-----APPAMQTYEEKPSEGCFTEEEETPYTNLSSVERS 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..107	CDD:459697	19/103 (18%)
		IRS	138..233	CDD:460473	27/96 (28%)
dok3	XP_002664535.3	PH-like	6..121	CDD:473070	20/107 (19%)
		PTB_DOK1_DOK2_DOK3	151..249	CDD:269914	27/98 (28%)