DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dok and frs2

DIOPT Version :9

Sequence 1:	NP_572391.1	Gene:	Dok / 31667	FlyBaseID:	FBgn0029944	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001128281.1	Gene:	frs2 / 100038035	XenbaseID:	XB-GENE-479760	Length:	509	Species:	Xenopus tropicalis

Alignment Length:	537	Identity:	111/537 - (20%)
Similarity:	176/537 - (32%)	Gaps:	188/537 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 MLQMTPTELQLKSEDLGATIAMWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFR 223
            ::::|..||.|.:....:  ..|||..:|:|||....|:||:||:|.||:|:|.......:|:|
Frog    37 IMELTENELILYTRKRDS--VKWPYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELF- 98

  Fly   224 CMSAKMKSMKKLISGDSLSTLE--CGENQFSAAAGMEPGSRSPLPPS------PSSNPHGGEFEI 280
                  ..:::::..:|:|.:|  ..|........:....|:|..|.      |:..|....|
Frog    99 ------NMLQEIMQNNSISVVEEPVVERNPQTELDVPRTPRTPTTPGFSGSGVPNGYPRYPSF-- 155

  Fly   281 NSTQSCISLRGFISSNDSLNNFSAGGGGASGATATGGGVLGSTGGITLSVP-------ANSNSNS 338
                      |..||:.|..:.|.|        :|....:|......|.||       .|::...
Frog   156 ----------GEASSHPSSRHPSVG--------STRLPSVGEESTHPLLVPEDHVHTYVNTSGVQ 202

  Fly   339 SSSKHIPNKPPRKSPTTHCDKYRNIVK---------------YEPVAITTISSP----------- 377
            ...|..||.||.:..   |.....::.               .||..:..:..|
Frog   203 EDQKQRPNIPPAQEV---CVSNLEVIHGHSEPAVPERDPQVILEPEGVKFVLGPTPVQRQLMEKK 264

  Fly   378 ----------SANSDVNS----------------------SVILKPLEGESISLP-----ETAAD 405
                      |.|:..:|                      .::.:.|.|.|||..     .....
Frog   265 KLEKLEQNQASVNNGESSCPNNTEGDTGYDSDERRETPGNKMVYENLNGLSISSSGVRRGRVVPP 329

  Fly   406 LPPDLPLRNESASKAPPPER----DYECIENITEAWRTR--------GVG-------------DV 445
            :|.|:...|.||.:     |    :||.:.::...|.||        .:|             |.
Frog   330 IPTDIQNVNNSAQR-----RTALINYENLPSLPPVWETRKPSREEDESLGPKTPSLNGFHSNLDP 389

  Fly   446 RH------SERMPILCDTSEFVRQRSVSKSTCGSQNTPKIIDIDIGEGCTSATSISESNYDRLDF 504
            .|      :..:|:.....||.|:|.     |    ||.:.:.||.........:   ||.::|.
Frog   390 MHNYVNTENVTVPLSAHKVEFSRRRD-----C----TPTVFNFDIRRPSLEQRQL---NYIQVDL 442

  Fly   505 L----SPNNKTSSGYKTIVNVTPGNRIRCSPPPPNEYELIASPDTE------SFRKA---DDSHR 556
            .    |.|.:|.....|.:..||..|.          ||.|..|.|      :.:||   ||
Frog   443 EGGSDSDNPQTPKTPTTPLPQTPTRRT----------ELYAVIDIERTAAMSNLQKALPRDD--- 494

  Fly   557 GYGVLRKASTTTNNNNL 573
              |..||  |..|:.:|
Frog   495 --GTSRK--TRHNSTDL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..110	CDD:214574
		PH	6..107	CDD:278594
		PH-like	138..232	CDD:302622	23/72 (32%)
frs2	NP_001128281.1	PTB_FRS2	15..106	CDD:269913	23/77 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5513
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.030