DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dok and dok2

DIOPT Version :9

Sequence 1:	NP_572391.1	Gene:	Dok / 31667	FlyBaseID:	FBgn0029944	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_001341514.7	Gene:	dok2 / 100001537	ZFINID:	ZDB-GENE-080721-4	Length:	572	Species:	Danio rerio

Alignment Length:	566	Identity:	134/566 - (23%)
Similarity:	199/566 - (35%)	Gaps:	128/566 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KKACSRYCLLFKASRHGIARLEMCESKE------------DRNPKIFTLENCVKITQ---EPPPE 77
            ||....:.:|::.|...|:|||..|.|:            ..|.|:..:.:|:::::   |..|.
Zfish    47 KKWRKVWSVLYRESSCSISRLEFFEIKDGTPNTLEKANRKHENKKVIKMSDCIRVSEADVEGCPR 111

  Fly    78 R----LIHIVKRQATLTLSTSSEEELKDWITALQTVAFCDTSPSGGI-----------GAIEEDN 127
            .    |:...::.....:.|:   ||.|||..|..:||....|..|.           .|...||
Zfish   112 DCGPFLVETTEKTFVFAVETA---ELDDWIQKLCEIAFPMNWPEKGTMRGNSLHSEPDDATMADN 173

  Fly   128 DLYCSSFDGL--FIITLIPSEASIRCCIEPKTYMLQMTPTE-LQLKSEDLGATIAMWPYRFIRKY 189
            .||||....:  |.:|:..||||.||.:  |..:|..|.|: |.||....|..:..|||||:|::
Zfish   174 TLYCSRETTMKDFKVTVRRSEASERCSL--KGVVLLRTDTDSLLLKDPKTGEVLYSWPYRFLRRF 236

  Fly   190 GYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFRCMSAKMKSMKKLISGDSLSTLECGENQFSAA 254
            |.....|:|||||:|.:|||.|..|......:|:.:.|.:...:..|....:|.
Zfish   237 GRDKATFSFEAGRRCDSGEGSFEFDTKQGNAIFQSVEAAINLHRVNIPAKQMSN----------- 290

  Fly   255 AGMEPGSRSPLPPSPSSNPHGGEFEINSTQSCISLRGFISSNDSLNNFSAGGGGASGATATGGGV 319
                 ..|..:|..|..........|.|..|..|:|                   .||.......
Zfish   291 -----SDRDLMPSPPRMRAPVENIGIYSMVSDTSIR-------------------DGAKPPQNPQ 331

  Fly   320 LGSTGGITLSVPANSNSNSSSSKHIPNK-PPRKS----------PTTHCDKYRNIVKYEPVAITT 373
            |.     .|..|.........|.::..: |||||          ..|..:.|...:..:|..
Zfish   332 LS-----RLDAPTEKLLTGVKSLNLDTRPPPRKSQVKNFRSCPLANTEDEMYSRAMAPDPER--- 388

  Fly   374 ISSPSANSDVNSSVILKPLEGESISLPETAADLPPDLPLRNE-----SASKAPPPERDYECIENI 433
             .||....:      ||.......:..|:...||.|...:|.     :.:..||...:..|..|
Zfish   389 -GSPKEKRE------LKDRRSTCSNPEESDYSLPFDTIAKNVMVDIFATTNFPPNAGESNCENN- 445

  Fly   434 TEAWRTRGVGDVRHSERMPILCDTSEFVRQRSVSKSTCGSQNTPKIIDIDIGEGCTSATSISESN 498
                   ..|...::|.:..:.|.|. :|.|..:|.|...:....|.|..  |||..|.:...|.
Zfish   446 -------KKGTAENTEPLYDIIDESA-IRSRFANKQTHSYKRVEHIYDEP--EGCGVAPNAPPSL 500

  Fly   499 YDRLDFLSPNNKTSSGYKTIVNVTPGNRIRCSPPPPNEYELIASPD 544
            ||     .|.......:|.:..|        ..|..:||...||.|
Zfish   501 YD-----EPEEVKGHAWKMLGTV--------MDPSGHEYPYNASVD 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dok	NP_572391.1	PH	6..110	CDD:214574	23/100 (23%)
		PH	6..107	CDD:278594	22/97 (23%)
		PH-like	138..232	CDD:302622	37/94 (39%)
dok2	XP_001341514.7	PH_DOK1,2,3	34..146	CDD:270195	23/101 (23%)
dok2	XP_001341514.7	PTB_DOK1_DOK2_DOK3	183..280	CDD:269914	37/98 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574602
Domainoid	1	1.000	67	1.000	Domainoid score	I9768
eggNOG	1	0.900	-	-		E1_KOG4047
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004741
OrthoInspector	1	1.000	-	-		otm24992
orthoMCL	1	0.900	-	-		OOG6_110776
Panther	1	1.100	-	-	LDO	PTHR21258
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1028
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.740