DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg5 and ATG5

DIOPT Version :9

Sequence 1:	NP_572390.1	Gene:	Atg5 / 31666	FlyBaseID:	FBgn0029943	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_001273035.1	Gene:	ATG5 / 9474	HGNCID:	589	Length:	275	Species:	Homo sapiens

Alignment Length:	271	Identity:	130/271 - (47%)
Similarity:	181/271 - (66%)	Gaps:	9/271 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAHDREVLRMIWEGQIGICFQADRDEIVGIKPEPFYLMISRLSYLPLVTDKVRKYFSRYISAEHQ 65
            |..|::|||.:|.|:|..||...:|||...:.||:||::.|:|||.||||||:|:|.: :..:..
Human     1 MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQK-VMRQED 64

  Fly    66 DGAVWFDFNGTPLRLHYPIGVLYDLLHPEEDSTPWCLTIHFSKFPEDMLVKLNSKELLESHYMSC 130
            ...:||::.||||:.|||||:|:||| ....:.||.:|:||..|||..|:...||:.:|:|:|||
Human    65 ISEIWFEYEGTPLKWHYPIGLLFDLL-ASSSALPWNITVHFKSFPEKDLLHCPSKDAIEAHFMSC 128

  Fly   131 LKEADVLKHRGLVISAMQKKDHNQLWLGLVNEKFDQFWAVNRRLMEPYGDLESFKNIPLRIY-TD 194
            :||||.|||:..||:.||||||.|||:||.|::||||||:||:|||...:...|:.||.||| |.
Human   129 MKEADALKHKSQVINEMQKKDHKQLWMGLQNDRFDQFWAINRKLMEYPAEENGFRYIPFRIYQTT 193

  Fly   195 DDFTYTQKLISPISVGGQKKSLADLMAELSTPV------RRAVGCRTHGIDLHEETQLQWMSEHL 253
            .:..:.|||..|::..||..:|.||:.|:....      .:......|||:...||.|||:||||
Human   194 TERPFIQKLFRPVAADGQLHTLGDLLKEVCPSAIDPEDGEKKNQVMIHGIEPMLETPLQWLSEHL 258

  Fly   254 SYPDNFLHLSV 264
            ||||||||:|:
Human   259 SYPDNFLHISI 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg5	NP_572390.1	APG5	81..264	CDD:282025	94/189 (50%)
ATG5	NP_001273035.1	APG5	79..270	CDD:397981	95/192 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152941
Domainoid	1	1.000	195	1.000	Domainoid score	I3167
eggNOG	1	0.900	-	-		E1_KOG2976
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3566
Inparanoid	1	1.050	269	1.000	Inparanoid score	I3032
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59300
OrthoDB	1	1.010	-	-		D457861at2759
OrthoFinder	1	1.000	-	-		FOG0004713
OrthoInspector	1	1.000	-	-		oto88490
orthoMCL	1	0.900	-	-		OOG6_103775
Panther	1	1.100	-	-	LDO	PTHR13040
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R110
SonicParanoid	1	1.000	-	-		X3313
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800