DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brk and Daxx

DIOPT Version :9

Sequence 1:	NP_511069.3	Gene:	brk / 31665	FlyBaseID:	FBgn0024250	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_001285675.1	Gene:	Daxx / 33906	FlyBaseID:	FBgn0031820	Length:	1659	Species:	Drosophila melanogaster

Alignment Length:	740	Identity:	142/740 - (19%)
Similarity:	226/740 - (30%)	Gaps:	260/740 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 HRRQIQKWLQCESNLRSSVANNQQQQQQ-----QQQQQQQQQQQQQLL---PQQSV---SPTPAV 133
            |.:|.|:        ::.:...||:||:     |||:|||||||:::|   .||.|   .|.|..
  Fly   428 HLQQQQQ--------KTFLGQLQQEQQKILGQLQQQKQQQQQQQKKILGQSQQQKVPLGQPQPQQ 484

  Fly   134 KVFHQLSHPLVH-QLHHHHAAAVGHHHHHAAHHHAAHHHHAAAAAAAAAAAAAAAAAHHHAAHHL 197
            |:..||::.||. |..|....:||.                               ......|..
  Fly   485 KLPQQLNNSLVQLQQQHQQRTSVGQ-------------------------------LQQQQPHQS 518

  Fly   198 LAANGMVPHPLAAHPHLHVPVAMHPQM-------QHQKEQQQQQQ----QLQQEQQQQD------ 245
            ...|.||          |  |...||.       |.|::.||||:    ||||:.|||.
  Fly   519 QQKNSMV----------H--VKQQPQQQKKISVGQFQQQPQQQQKTSVAQLQQQPQQQQKISVGQ 571

  Fly   246 -QQQSQQETPATIATNGSNQGSSNVLSAAKIAAVVAAAMATSNG----NPTPTATIPASSSSSSN 305
             ||||||:...::................::.........||.|    .|.....|.|.....
  Fly   572 LQQQSQQQQKPSVGQLQQQSQQQQTPLVGQLQRQTQQQQKTSAGQFQQQPQQQQKISAGQLQE-- 634

  Fly   306 TLPSSNNSSCHNSSSSSNSCNSNQVPIQVPILSGSPGSTSSASHIPHVPFAYHHNLHGYLENRLE 370
                      |:...........|...|.. |:.|.|........|....|..
  Fly   635 ----------HSQQQQKTLAGQLQQQAQQQ-LNTSAGQLQQQQKPPKASLAQQ------------ 676

  Fly   371 AVATPAPMDLSLGSSARRQMQLHEKDPSGV--DLTFRKRKVITSPM---------QPDKISKLEE 424
              |........||...:.|.|..::..:|:  .....::|::..|.         :|.::.|...
  Fly   677 --AAAQKQGAGLGQQQQFQSQPQQRTSAGLLQQQQMPQKKIVMQPQLPKTSVVLPRPQQLPKNPL 739

  Fly   425 VI--KKEPETETENEDVEVDVETEQPE-------EHK------LPSKQ-VKLFKPYLLDDDEEQD 473
            ::  ::.|:|...|..:.....::||.       .||      ||..| |:...|..:...:...
  Fly   740 LVAQQQSPKTPLVNSVMGPQFPSQQPSLPVVNQITHKSMTIQRLPMLQTVQKILPKQIAPQQTPP 804

  Fly   474 HHHHHHHHRQEDLDEGAAEEEQDDEEESRYADDDEVDSKEAADKKQRRLKKKPSAINEQREPI-- 536
            ..|                                :..|:.  .....::..|.|   .|.||
  Fly   805 PAH--------------------------------IVQKQT--MPNAAMQNPPFA---HRPPIVR 832

  Fly   537 ---IWSNHPYPGG---CVSPGSSITSSFQCPT--SMQQQQTFP---------------------V 572
               :....|.|..   |: |.....:|:..||  :|...:|.|                     .
  Fly   833 PMTVAKISPVPTNNKVCI-PMKPQMASYVSPTDPTMTAARTLPFRSSQRKTSEAPMTSTHVQGFT 896

  Fly   573 AGGSPNQQF---QDNCSSS---------KATTPLSPFSAPALSPTGFCCPKGSPVSGY------- 618
            |..:|.|:.   ..:|:::         ..||.::|...|..:|     |...|.:..
  Fly   897 ASATPPQRLLATPPHCAAALNEPLLLNLPPTTSITPQLTPTTTP-----PPAGPSAAVQQQQLAK 956

  Fly   619 ----------ESSSSTYSDSGSNYSLNLQLHAVYNDNLMYMQQQQQQQQQQHHLQHQQHLQRWLD 673
                      |:|.|..:.|.:..:..:|...|...:....|:..:||||:.|:|        |.
  Fly   957 AAAIKLNSLPEASISPVNRSPTASAKRIQPITVLKKSDEEWQRHLEQQQQKKHVQ--------LQ 1013

  Fly   674 QESLATARTSSVNRPLILVADTAPT 698
            ..|:.|          |::.::.||
  Fly  1014 SSSMTT----------IVLVESPPT 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brk	NP_511069.3	BrkDBD	43..100	CDD:286662	3/19 (16%)
Daxx	NP_001285675.1	PTZ00449	<278..>379	CDD:185628
		PRK10263	<707..>892	CDD:236669	33/222 (15%)
		DAXX_histone_binding	1276..1462	CDD:240523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12766
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100