DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Farp2 and Cdep

DIOPT Version :9

Sequence 1:	NP_001101703.1	Gene:	Farp2 / 316639	RGDID:	1308003	Length:	1060	Species:	Rattus norvegicus
Sequence 2:	NP_001097685.2	Gene:	Cdep / 40608	FlyBaseID:	FBgn0265082	Length:	4273	Species:	Drosophila melanogaster

Alignment Length:	1031	Identity:	287/1031 - (27%)
Similarity:	449/1031 - (43%)	Gaps:	269/1031 - (26%)

- Green bases have known domain annotations that are detailed below.

  Rat    12 PTSGTRLGGQTAIGVSTLEPEQALSPKMQEKH-----MHIRVKLLDSTVEIFDIEPKCDGQVLLT 71
            |..|...||:....:||  |..........:|     :.:|:::||.::.:|.::.|..|:||..
  Fly    34 PVGGGLPGGRMTHSLST--PSGVDGTPSTPRHRGGKKLTVRIQMLDDSITMFQVQAKALGRVLFE 96

  Rat    72 QVWKHLNLIECDYFGLEFKNVQS---YWIWLEPMKPIIRQVRKPK-NAVLRLAVKFFPPDPGQLQ 132
            ||.:.|||:|.||||||::.|.:   ||:.||  ||:.|||.... :.|||..:||:.|||.||:
  Fly    97 QVCRQLNLLEADYFGLEYQEVSTHTKYWLDLE--KPMNRQVGLSLIDPVLRFCIKFYTPDPAQLE 159

  Rat   133 EEYTRYLFALQLRRDLLEERLTCTATTSALLISHLLQSEIGDY--DETLDREHLKANDYLPNQEQ 195
            ||||||||.||::|||....|.|...|:||:.|:::|:..||:  ::..|..:|.:..::|||:.
  Fly   160 EEYTRYLFCLQIKRDLATGSLQCNDNTAALMASYIVQASCGDFVPEDYPDHTYLSSYRFVPNQDA 224

  Rat   196 SLD-KILDFHQRHTGQTPADSDFQVLEIARKLEMYGIRFHMASDREGTKINLAVSHMGVLVFQGT 259
            ::. ||::.|::|.||:||::|..:||.||:.|:||::.|.|.|.||..:||||:|||:.|||..
  Fly   225 TMQRKIMENHKKHVGQSPAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNI 289

  Rat   260 TKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEHHTFFRLSD 324
            |:||||:|:|:||:||||||||:|||||.:|.|:||:||....|:|||||||.|||:|.|||.:.
  Fly   290 TRINTFSWAKIRKISFKRKRFLVKLHPEGYGYYKDTVEFFFEGRNECKNFWKKCVENHGFFRCTA 354

  Rat   325 -QPKPKAKAVFFSRGSSFRYSGRTQKQLVDYIRDGGTKRIPYERRHS--------KTRTSLHT-- 378
             |..|:.|....||||||||||:||||:::::|:...||..::|..|        .:|:..||
  Fly   355 VQNTPRRKTRVLSRGSSFRYSGKTQKQIIEFVRENYVKRQNFQRSQSFRQGPLNASSRSQSHTYV 419

  Rat   379 --------------------------LTGDLPKQSISFTDGLRTS------ASLSSANASFYPPP 411
                                      :|..|.|::....|..|.:      :.:::|....|...
  Fly   420 NSSISANPLLPIDTAAWDYRNQCSDSMTPSLTKKAADTLDRRRDNPIGHMRSQVTAAQVEIYQTK 484

  Rat   412 T-SLSSPGLPSVKDSSSSPVDPQAPHIKSTAAER--SSRPSSSEGPS-----TQSAHL----PGP 464
            . :..||  .|.:::..|....:..|..:.|.::  |:|..|.:||.     :.|:|.    |.|
  Fly   485 NYAADSP--TSQEEAECSAAGAERQHHSAVAMDKLNSNRSLSPQGPQSWTSPSHSSHHQQRGPDP 547

  Rat   465 PVLQPG-------------------------PGFSVDSPQ------PSPSS------LKSRLSLS 492
            ..:.||                         ..|...|||      ||.|:      ..|.:..|
  Fly   548 ARVHPGDHNTGLSHLSHLYSSSTPRRVSVGSQAFVPASPQLISINTPSSSTNHNTMHSTSTVVRS 612

  Rat   493 PERQASLSTAEQGSSPVLSPVLSGTGTARMDNQEEQKHKHTSEDEAYFIAKEIVATERTYLKDLE 557
            .:..:|:...|:...|         |||  |.:||:......|:|...:.:|:.:       ||.
  Fly   613 VDLNSSMELEEEAEDP---------GTA--DTEEEEGEPVGEEEEEELVEEEVDS-------DLT 659

  Rat   558 VITVWFRSVVIKEEAMPAALMTLLFSNI--DPIYEFHRGFLHEVEQRLALWEGP---SSGDHQRI 617
            ..|       |..|.|.||......::.  ..:...||..|...|.: :|...|   ||.::...
  Fly   660 AST-------INRETMGAASAAAASASALGSGLASAHRPQLRSQESQ-SLTATPVHYSSTNYSMS 716

  Rat   618 GDILLRNMRQLKEFTSYFQRHDEVLTELEKATKHCKRLEAVYKEFELQKVCYLPLNTFLLKPVQR 682
            ...:|.|                              ..|...|.|...:.|..:|.
  Fly   717 KQCMLNN------------------------------ANANSTETETDNIIYTDIND-------- 743

  Rat   683 LVHYRLLLNRLCTHYSPEHEDYTDCHEALKAITEVTTELQQSLTRLENLQKLTELQRDLVGVENL 747
            :.||:                |.|.|.        :...:..::..|:| .|.| :.|:....|
  Fly   744 MGHYK----------------YPDFHS--------SAHQEHKISNSEHL-NLNE-RNDIYATVN- 781

  Rat   748 IAPGREFIREGCLHKLTKKGLQQRMF---FLFSDMLLYTSKSVTGASQFRIRGFLPLRGMLVEDS 809
                          :..|..::::.|   |:...:|.||.....|.||..:        :|.:.|
  Fly   782 --------------RKAKSKIREKHFSDEFIDQSILQYTRAKQMGLSQVPV--------LLQQPS 824

  Rat   810 ENEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMQDLNAAIQAAKSAGDTPAVLLGGPVYTRSPRS 874
            .:.::.       |.|:....:.|     .::..|||...:::.|:      ..|....|:....
  Fly   825 TSAYAA-------ALQERSYNSGS-----YQYHNDLNHPSESSSSS------YFGTGFGTKRYGQ 871

  Rat   875 SDEVSLEDSEDGRGTRGSLEGNSQHRANTTMHVCWYRNTSVSRADHSAAVENQLSG 930
            |:...|..||:  ....||:..|                  ||..||....::|||
  Fly   872 SERTKLAQSEN--YLTPSLDSQS------------------SRHTHSLPRNSELSG 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Farp2	NP_001101703.1	B41	45..234	CDD:214604	83/195 (43%)
		FERM_C_FARP1-like	221..341	CDD:270014	71/120 (59%)
		FA	333..375	CDD:400882	20/49 (41%)
		RhoGEF	539..718	CDD:238091	29/183 (16%)
		PH1_FARP1-like	747..853	CDD:269928	17/108 (16%)
		PH2_FARP1-like	924..1021	CDD:270055	3/7 (43%)
Cdep	NP_001097685.2	B41	70..264	CDD:214604	83/195 (43%)
		FERM_N	73..134	CDD:286467	26/62 (42%)
		FERM_B-lobe	163..256	CDD:271216	37/92 (40%)
		FERM_C_FARP1-like	251..372	CDD:270014	71/120 (59%)
		FA	364..406	CDD:285894	19/41 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8877
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45402
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45858
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.010