DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2059 and ABHD8

DIOPT Version :9

Sequence 1:	NP_001188553.1	Gene:	CG2059 / 31663	FlyBaseID:	FBgn0029942	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_078803.4	Gene:	ABHD8 / 79575	HGNCID:	23759	Length:	439	Species:	Homo sapiens

Alignment Length:	265	Identity:	66/265 - (24%)
Similarity:	118/265 - (44%)	Gaps:	41/265 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LLTYHGLFGSKQNWRGISKALVRKVSRKVYAIDVRNHGESPHSSV---HNSKAMSEDLRLFMEQR 116
            |...||:.||...|:......|| :..:|.|.|:..||.|....|   :...|::||:|...::.
Human   178 LFFIHGVGGSLAIWKEQLDFFVR-LGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFKRY 241

  Fly   117 SHPNAACMGHSMGGRSMMYFARKYPELVERLIVVD-ISPISVPRSTGEMTEIFD--AMVSLDLSP 178
            :......:|||.|.....:.|.:||:||.::|::: ..|.::..|   ...||:  ..|...|||
Human   242 AKKRNVLIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPS---FCSIFNMPTCVLHCLSP 303

  Fly   179 SMSMS-----EGRKIAREK-LLKATEDETVDFIMLNLRKNPDTGAFSWACNAHVLREFLTRFDKY 237
            .::.|     ..|:.|:|| |||                  :..||:  .::.|||..::  .:|
Human   304 CLAWSFLKAGFARQGAKEKQLLK------------------EGNAFN--VSSFVLRAMMS--GQY 346

  Fly   238 QSNLEEL--PPYTGPTTFICGTRSPYMRREQWPQIQKMFPNSEIHWLDAG-HLVHFEKPQEFLTI 299
            ....:|:  ...|.|...:.|....::..|:..::.::...:.:..:|.| |:|..|.|:...|:
Human   347 WPEGDEVYHAELTVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLIDEGSHMVMLECPETVNTL 411

  Fly   300 VSEFL 304
            :.|||
Human   412 LHEFL 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2059	NP_001188553.1	PRK10673	38..305	CDD:182637	66/265 (25%)
		Abhydrolase_5	54..>151	CDD:289465	29/98 (30%)
		Abhydrolase	<253..287	CDD:304388	4/34 (12%)
ABHD8	NP_078803.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..156
		MhpC	156..416	CDD:223669	64/263 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2382
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810