Protein Alignment CG1677 and ZC3H18

DIOPT Version :9

• Sequence 1: NP_001284976.1
• Gene: CG1677 / 31662
• FlyBaseID: FBgn0029941
• Length: 1000
• Species: Drosophila melanogaster
• Sequence 2: NP_001281269.1
• Gene: ZC3H18 / 124245
• HGNCID: 25091
• Length: 977
• Species: Homo sapiens
• Alignment Length: 1149
• Identity: 282/1149 - (24%)
• Similarity: 401/1149 - (34%)
• Gaps: 484/1149 - (42%)

  Fly   149 PGSPNAKSQPSSFLSSVRSRSVSPQLYNQAAVDLNISHDDLSD---------VSDIEGEEKRTSS 204
            |.||..:.||                  |...|.:|..|..||         .||:|.||.....
Human    11 PHSPEDEEQP------------------QGLSDDDILRDSGSDQDLDGAGVRASDLEDEESAARG 57

  Fly   205 KNSMRPADENEDGAISNDSLPTLGEEDEVEQKQS---------TPNGKASS-----GDEKEPFAK 255
                 |:.|.||    |.|    .|||...:.:|         ...|..||     |||.|
Human    58 -----PSQEEED----NHS----DEEDRASEPKSQDQDSEVNELSRGPTSSPCEEEGDEGE---- 105

  Fly   256 ETHTDDASNGLAPATALQEDLVKTHDDDALDFEAEEGECPEQAKEPSPMESTANETNQTKSTTKV 320
            |..|.|..:   .|:::..:|    |:..||::.   |.||   ||:|               .|
Human   106 EDRTSDLRD---EASSVTREL----DEHELDYDE---EVPE---EPAP---------------AV 142

  Fly   321 SQDEGDDDGEVDKDGDDKDGDDKDTRKDGAG------NGCLEDGAGNDSRKDDAGNGCLEEGEEE 379
            .:||.:..|..|   |::.|:.....:..||      ...||  |..:.:|:| .:|.:::||
Human   143 QEDEAEKAGAED---DEEKGEGTPREEGKAGVQSVGEKESLE--AAKEKKKED-DDGEIDDGE-- 199

  Fly   380 KDIVSVSTSSSQEKVEEGELEEGEVSDEDEKRPEETEPKPVCRFY-------------------- 424
                          :::.:||||||.|..:::   ..|:|.|||:
Human   200 --------------IDDDDLEEGEVKDPSDRK---VRPRPTCRFFMKDVVTPLSTLLPPISNSIP 247

  Fly   425 ----TRGQCTWGMSCRFLHPGVTDKGNYTMFDNVIRPVPMQGGSTGASAPAAPSSTAAPRAGGSA 485
                .:|.|||||:|||:||||.|||||::.... .|.|..|     :.|..|.
Human   248 FRGQVKGNCTWGMNCRFIHPGVNDKGNYSLITKA-DPFPPNG-----APPLGPH----------- 295

  Fly   486 YSSHASATADYHDYRTERPLHHRPPLLHAPSIYGAPVHDARTLLPDGAP-VVVENAWERGLRTAK 549
                                    ||:.| :.:|.||.|  .:||...| ...|:|||||||.||
Human   296 ------------------------PLMPA-NPWGGPVVD--EILPPPPPEPPTESAWERGLRHAK 333

  Fly   550 EMMRKANKRKEQDMDFEDKKMNLTLSPDEME--KDSYYLKDRGGSSARSPPPPSANVREQPLNPL 612
            |:::||..||||:.|||:|:..:|:..||.|  |::...:|   .::|.|    .:||:..|.|
Human   334 EVLKKATIRKEQEPDFEEKRFTVTIGEDEREFDKENEVFRD---WNSRIP----RDVRDTVLEP- 390

  Fly   613 SMPLSMHPHAVAHANPRALLPLQYSVYGPPPDRY---GRPQYMPPQYDDVDAY----------GR 664
                        :|:|         .|....:|:   |:.:....||.:.:.|          .|
Human   391 ------------YADP---------YYDYEIERFWRGGQYENFRVQYTETEPYHNYRERERERER 434

  Fly   665 MTRYRELPPHRMPHYEDDRRSR------------------------------------------- 686
            ..|.||....|....|.:||.|
Human   435 ENRQRERERERERDRERERRQRERERERERERDKERQRRKEEWERERAKRDEKDRQHRDRDREKE 499

  Fly   687 ---------------PTREVIVQRVEAA------GRGDEWSDPWMRSKSVGR--GSYEREDRRRR 728
                           |:|:....:.|||      .|.|||.|||.||||..:  |......|.||
Human   500 REKEKGKPKPRSPQPPSRQAEPPKKEAATTGPQVKRADEWKDPWRRSKSPKKKLGVSVSPSRARR 564

  Fly   729 DRRSYSSNSSYSTSNSSQSDSSSDS----------SRSSSPSDHKRRYGSH-KLATATATSRRHG 782
            .|:  :|.||.|.||||:|.|.|.|          |||||.|.:..|...| ..:.:.:.||...
Human   565 RRK--TSASSASASNSSRSSSRSSSYSGSGSSRSRSRSSSYSSYSSRSSRHSSFSGSRSRSRSFS 627

  Fly   783 GRAARSPSQIPRRPRRTSKGSLSP--------SYKRPAVDKRGVGHSPSS--KRKKLSSPAP--- 834
            ...:.||:..|.||...:||..:|        |.|:||        .|.:  :..|.::|.|
Human   628 SSPSPSPTPSPHRPSIRTKGEPAPPPGKAGEKSVKKPA--------PPPAPPQATKTTAPVPEPT 684

  Fly   835 KKFDKLRRRRSSSSSDSDSSDTSYSDSESGSSSSDSSSGSRETPQKRVRATDKALNERKL-ISKP 898
            |..|....||....:.:.....:.|.|.|||.||.|.|.||               .|.| :|..
Human   685 KPGDPREARRKERPARTPPRRRTLSGSGSGSGSSYSGSSSR---------------SRSLSVSSV 734

  Fly   899 AEQSTKKRSPISIEIKKTSNMVG--VSALASASNSADSDAEKDHDNGKDKEKDHVKEK------- 954
            :..|:...|..|.....:.:|..  .|.::|||:.:.:.|:...:.||.|::|.|||:
Human   735 SSVSSATSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQTRKEKGKSKKEDGVKEEKRKRDSS 799

  Fly   955 --------------------------------------------------DKDCKEK----DKDK 965
                                                              ||..:::    |||:
Human   800 TQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTFVAHKEIKLTLLNKAADKGSRKRYEPSDKDR 864

  Fly   966 D--------------GMKD---------------------------------------------- 970
            .              |.:|
Human   865 QSPPPAKRPNTSPDRGSRDRKSGGRLGSPKPERQRGQNSKAPAAPADRKRQLSPQSKSSSKVTSV 929

  Fly   971 ------------KEGKK---SRREELLKQLRAVEDAIAKKRSKL 999
                        |.||.   ||||||||||:|||||||:||:|:
Human   930 PGKASDPGAASTKSGKASTLSRREELLKQLKAVEDAIARKRAKI 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1677	NP_001284976.1	ZnF_C3H1	419..440	CDD:214632	13/44 (30%)
ZC3H18	NP_001281269.1	MDN1	<17..187	CDD:227596	56/237 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159446
Domainoid	1	1.000	47	1.000	Domainoid score	I12078
eggNOG	1	0.900	-	-		E1_2CI32
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4179
Isobase	1	0.950	-	0	Normalized mean entropy	S7557
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008353
OrthoInspector	1	1.000	-	-		oto91818
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46582
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.890