DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9650 and ZNF235

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_004225.3	Gene:	ZNF235 / 9310	HGNCID:	12866	Length:	738	Species:	Homo sapiens

Alignment Length:	519	Identity:	121/519 - (23%)
Similarity:	178/519 - (34%)	Gaps:	152/519 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   625 TSPGAGSTVNSSSPSPRQKQSPHFA----SPSPSQQQQQQLATIPRPHSLTPPEKLGDASSENGS 685
            ||..:|..|..|..:.:::...|..    |.|.:.|..|::.|..:|::.....|..:.||.
Human   300 TSYSSGIPVQQSVRTGKKRYWCHECGKGFSQSSNLQTHQRVHTGEKPYTCHECGKSFNQSSH--- 361

  Fly   686 LGLILASTPRSASTPP----------SKTGDVSLQEPIAHC--------YSCSYCDKKFRFENNL 732
               :.|..|......|          |::.|:::     ||        |.|..|.|.|...::|
Human   362 ---LYAHLPIHTGEKPYRCDSCGKGFSRSTDLNI-----HCRVHTGEKPYKCEVCGKGFTQRSHL 418

  Fly   733 IIHQRTHTGEKPYKCTACD--FECSHIQKLMKHMRVHRSPADDQDNQDNQDDGSNADSLETNEAD 795
            ..|:|.|||||||||..|.  |.||  ..|..|.|||     .::.....|:.....||..|.
Human   419 QAHERIHTGEKPYKCGDCGKRFSCS--SNLHTHQRVH-----TEEKPYKCDECGKCFSLSFNL-- 474

  Fly   796 NDEDPNPDESEEELGDGDNDPDGDGDLDGEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKT 860
                    .|.:.:..|:.                        .||.|:...........||.:.
Human   475 --------HSHQRVHTGEK------------------------PYKCEECGKGFSSASSFQSHQR 507

  Fly   861 TSSGATSLVGELMDKFGLSNIAQYSEAYKQALQESGRKEAAAAAAAAAAAADNNNRGGAGAPLSD 925
            ..:|.......:..| |.|. :.|.:|:::.  .:|.|                       |...
Human   508 VHTGEKPFRCNVCGK-GFSQ-SSYFQAHQRV--HTGEK-----------------------PYKC 545

  Fly   926 KLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNPFPNPFELSKRMKMDGGDWWGMSQA- 989
            ::.|       .|..::.|.:..|:...|..|.:..         |..|          |.|||
Human   546 EVCG-------KRFNWSLNLHNHQRVHTGEKPYKCE---------ECGK----------GFSQAS 584

  Fly   990 -------LHRNEALFENLKLKPLGLGGANS-LIQGPLLKKESR----QRNDTCEFCGKVFKNCSN 1042
                   :|..|        ||........ ..|...|:...|    ::...|:.|||.|...||
Human   585 NLQAHQSVHTGE--------KPFKCDACQKRFSQASHLQAHQRVHTGEKPYKCDTCGKAFSQRSN 641

  Fly  1043 LTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEKHMR 1106
            |.||:..||||||:|||.|....:.|:.|:.|.:.|  ||:..|.|:.|...||..|....|.|
Human   642 LQVHQIIHTGEKPFKCEECGKEFSWSAGLSAHQRVH--TGEKPYTCQQCGKGFSQASHFHTHQR 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	8/21 (38%)
		C2H2 Zn finger	719..739	CDD:275368	7/19 (37%)
		zf-H2C2_2	731..756	CDD:338759	15/26 (58%)
		C2H2 Zn finger	747..767	CDD:275368	8/21 (38%)
		zf-C2H2	1029..1050	CDD:333835	10/20 (50%)
		C2H2 Zn finger	1030..1050	CDD:275368	10/19 (53%)
		zf-H2C2_2	1042..1067	CDD:338759	14/24 (58%)
		C2H2 Zn finger	1058..1078	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1088..1106	CDD:275368	6/17 (35%)
ZNF235	NP_004225.3	KRAB A domain	6..47
		KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		KRAB B domain	48..80
		C2H2 Zn finger	266..285	CDD:275368
		COG5048	321..662	CDD:227381	102/453 (23%)
		C2H2 Zn finger	321..341	CDD:275368	5/19 (26%)
		zinc finger domain	321..341		5/19 (26%)
		zf-H2C2_2	333..358	CDD:290200	5/24 (21%)
		C2H2 Zn finger	349..369	CDD:275368	5/25 (20%)
		zinc finger domain	349..369		5/25 (20%)
		C2H2 Zn finger	377..397	CDD:275368	4/24 (17%)
		zinc finger domain	377..397		4/24 (17%)
		zf-H2C2_2	389..414	CDD:290200	8/29 (28%)
		C2H2 Zn finger	405..425	CDD:275368	7/19 (37%)
		zinc finger domain	405..425		7/19 (37%)
		zf-H2C2_2	417..442	CDD:290200	14/24 (58%)
		C2H2 Zn finger	433..453	CDD:275368	8/21 (38%)
		zinc finger domain	433..453		8/21 (38%)
		zf-H2C2_2	448..469	CDD:290200	5/25 (20%)
		C2H2 Zn finger	461..481	CDD:275368	5/29 (17%)
		zinc finger domain	461..481		5/29 (17%)
		zf-H2C2_2	476..498	CDD:290200	5/45 (11%)
		C2H2 Zn finger	489..509	CDD:275368	3/19 (16%)
		zinc finger domain	489..509		3/19 (16%)
		zf-H2C2_2	501..526	CDD:290200	5/25 (20%)
		C2H2 Zn finger	517..537	CDD:275368	5/23 (22%)
		zinc finger domain	517..537		5/23 (22%)
		zf-H2C2_2	529..553	CDD:290200	7/55 (13%)
		C2H2 Zn finger	545..565	CDD:275368	4/26 (15%)
		zinc finger domain	545..565		4/26 (15%)
		zf-H2C2_2	560..582	CDD:290200	6/40 (15%)
		C2H2 Zn finger	573..593	CDD:275368	6/38 (16%)
		zinc finger domain	573..593		6/38 (16%)
		zf-H2C2_2	585..610	CDD:290200	4/32 (13%)
		C2H2 Zn finger	601..621	CDD:275368	3/19 (16%)
		zinc finger domain	601..621		3/19 (16%)
		zf-H2C2_2	613..638	CDD:290200	7/24 (29%)
		C2H2 Zn finger	629..649	CDD:275368	10/19 (53%)
		zinc finger domain	629..649		10/19 (53%)
		zf-H2C2_2	641..665	CDD:290200	14/23 (61%)
		C2H2 Zn finger	657..677	CDD:275368	6/19 (32%)
		zinc finger domain	657..677		6/19 (32%)
		zf-H2C2_2	670..694	CDD:290200	9/25 (36%)
		C2H2 Zn finger	685..705	CDD:275368	7/19 (37%)
		zinc finger domain	685..705		7/19 (37%)
		C2H2 Zn finger	713..733	CDD:275368
		zinc finger domain	713..733
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000