DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9650 and ZNF845

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001308451.1	Gene:	ZNF845 / 91664	HGNCID:	25112	Length:	970	Species:	Homo sapiens

Alignment Length:	439	Identity:	107/439 - (24%)
Similarity:	151/439 - (34%)	Gaps:	110/439 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 YSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPADDQDNQDNQD 781
            |.|..|||.|.|::||..|::.|||||||||..|....|....|.:|.|:|......:.|...:.
Human   355 YKCEECDKAFSFKSNLERHRKIHTGEKPYKCNECSRTFSRKSSLTRHRRLHTGEKPYKCNDCGKT 419

  Fly   782 DGSNADSLETNEADNDEDPNPDESEEELGDGDNDPDGDGDLDGEDEDEDELEECEDMDYKAEDLS 846
            ....:..:........|.|.                             :.|||::......:|.
Human   420 FSQMSSLVYHRRLHTGEKPY-----------------------------KCEECDEAFSFKSNLE 455

  Fly   847 VSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQALQESGRKEAAAAAAAAAAAA 911
            ...||....:..|....|.|              .:|.|.........:|.|.........|.:.
Human   456 RHRRIHTGEKPYKCNDCGKT--------------FSQTSSLVYHRRLHTGEKPYKCEECDEAFSF 506

  Fly   912 DNNNRGGAGAPLSDKL---NGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNPFPNPFELS 973
            .:|..........:||   |.......| :....::|.:    ..|..|.|..         |..
Human   507 KSNLERHRIIHTGEKLYKCNECGKTFSR-KSSLTRHCRL----HTGEKPYQCN---------ECG 557

  Fly   974 KRMKMDGGDWWGMS-----QALHRNEALFENLKLKPLGLGG-----------ANSLIQGPLLKKE 1022
            |..:       |.|     ||:|              |:|.           :|:.......:..
Human   558 KAFR-------GQSALIYHQAIH--------------GIGKLYKCNDCHQVFSNATTIANHWRIH 601

  Fly  1023 SRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYR 1087
            :.:|:..|..|||.|::.|.|.||.|:|:||||||||.|..|.:..|.|.||.:.|  ||:..||
Human   602 NEERSYKCNRCGKFFRHRSYLAVHWRTHSGEKPYKCEECDEAFSFKSNLQRHRRIH--TGEKPYR 664

  Fly  1088 CRFCDMPFSVPSTLEKHMR--------KCVVNQ-GKAAAAANAVAAAQA 1127
            |..|...||..|.|..|.|        ||  |: ||.....:|:...:|
Human   665 CNECGKTFSRKSYLTCHRRLHTGEKPYKC--NECGKTFGRNSALIIHKA 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	10/21 (48%)
		C2H2 Zn finger	719..739	CDD:275368	9/19 (47%)
		zf-H2C2_2	731..756	CDD:338759	13/24 (54%)
		C2H2 Zn finger	747..767	CDD:275368	6/19 (32%)
		zf-C2H2	1029..1050	CDD:333835	10/20 (50%)
		C2H2 Zn finger	1030..1050	CDD:275368	10/19 (53%)
		zf-H2C2_2	1042..1067	CDD:338759	15/24 (63%)
		C2H2 Zn finger	1058..1078	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1088..1106	CDD:275368	7/17 (41%)
ZNF845	NP_001308451.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	169..564	CDD:227381	54/272 (20%)
		C2H2 Zn finger	217..237	CDD:275368
		C2H2 Zn finger	245..265	CDD:275368
		C2H2 Zn finger	273..293	CDD:275368
		C2H2 Zn finger	301..321	CDD:275368
		C2H2 Zn finger	329..349	CDD:275368
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	13/24 (54%)
		COG5048	381..813	CDD:227381	93/413 (23%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	5/24 (21%)
		C2H2 Zn finger	413..433	CDD:275368	1/19 (5%)
		C2H2 Zn finger	441..461	CDD:275368	5/19 (26%)
		zf-H2C2_2	453..478	CDD:290200	6/38 (16%)
		C2H2 Zn finger	469..489	CDD:275368	4/33 (12%)
		C2H2 Zn finger	497..517	CDD:275368	2/19 (11%)
		zf-H2C2_2	509..534	CDD:290200	4/24 (17%)
		C2H2 Zn finger	525..545	CDD:275368	3/24 (13%)
		zf-H2C2_2	537..560	CDD:290200	6/35 (17%)
		C2H2 Zn finger	553..573	CDD:275368	6/35 (17%)
		C2H2 Zn finger	581..601	CDD:275368	1/19 (5%)
		C2H2 Zn finger	609..629	CDD:275368	10/19 (53%)
		C2H2 Zn finger	637..657	CDD:275368	8/19 (42%)
		zf-H2C2_2	649..674	CDD:290200	11/26 (42%)
		C2H2 Zn finger	665..685	CDD:275368	8/19 (42%)
		C2H2 Zn finger	693..713	CDD:275368	6/21 (29%)
		C2H2 Zn finger	721..741	CDD:275368
		C2H2 Zn finger	749..769	CDD:275368
		zf-H2C2_2	761..786	CDD:290200
		C2H2 Zn finger	777..797	CDD:275368
		C2H2 Zn finger	805..825	CDD:275368
		C2H2 Zn finger	833..853	CDD:275368
		zf-H2C2_2	845..870	CDD:290200
		C2H2 Zn finger	861..881	CDD:275368
		zf-H2C2_2	873..898	CDD:290200
		C2H2 Zn finger	889..909	CDD:275368
		C2H2 Zn finger	917..937	CDD:275368
		C2H2 Zn finger	945..965	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000