DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and ZNF528

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_006723481.1	Gene:	ZNF528 / 84436	HGNCID:	29384	Length:	712	Species:	Homo sapiens

Alignment Length:	717	Identity:	147/717 - (20%)
Similarity:	231/717 - (32%)	Gaps:	212/717 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   447 LLRMPLPPALAQAGNVVPTVAPLFGRPSPADHYRMEQLVSEQFRHHGFNLAAAAAAAQAQFNANG 511
            |:|.|..|:   :|:.|.|...|.|.....:|:...|.......||    .::......|.:.:.
Human   107 LVRHPRSPS---SGSPVATCTDLGGLNEGGEHWNKRQRFPTAPMHH----LSSLCFLHCQHDTHN 164

  Fly   512 QVVGGVVSGSGEPRPPSSSSSGSQRGSVP-------PAALPPPSLSSQQQQQQQQAVQQQQQQGA 569
            .::...:|.|     ..||..||..|:.|       ...|....|...|.:::....:..::..:
Human   165 TLILLPMSES-----ERSSKLGSNAGNKPCKNQLGFTFQLHLSDLQLFQAERKISGCKHFEKPVS 224

  Fly   570 QQQLQSAQQQQQSQQQSQQQQQI------TPGLVGGAGGSLKLEPQQMDFYSQRLRQLAGTTSPG 628
            .....|..::..|..:|....:.      .|.|.......::.:..:.:.:.|..|..|..|:.
Human   225 DNSSVSPLEKISSSVKSHLLNKYRNNFDHAPLLPQEQKAHIREKAYKCNEHGQVFRASASLTNQ- 288

  Fly   629 AGSTVNSSSPSPRQKQSPHFASPSPSQQQQQQLATIPRPHSLTPPEKLGDASSENGSLGLILAST 693
              ...|:.:|....:....|:..|       :|....|.|:...|.|..:.       |.:.:|.
Human   289 --VIHNADNPYKCSECGKVFSCSS-------KLVIHRRMHTGEKPYKCHEC-------GKLFSSN 337

  Fly   694 PRSASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQ 758
            ...:......||    ::|    |.|..|||.||..:.|..|||.|||||||||..||...:.|.
Human   338 SNLSQHQRIHTG----EKP----YKCHECDKVFRSSSKLAQHQRIHTGEKPYKCHECDKVFNQIA 394

  Fly   759 KLMKHMRVHRSPADDQDNQDNQDDGSNADSLETNEADNDEDPNPDESEEELGDGDNDPDGDGDLD 823
            .|::|.::|........|:..:....::...|.......|.|
Human   395 HLVRHQKIHTGEKPYSCNKCGKVFSRHSYLAEHQTVHTGEKP----------------------- 436

  Fly   824 GEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAY 888
                            ||.|:.       ||:.|.:      :||:
Human   437 ----------------YKCEEC-------GKAFSVR------SSLI------------------- 453

  Fly   889 KQALQESGRKEAAAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRLRDEFAKNC-------- 945
            ...|..:|||                                |.........|.:.|
Human   454 THQLIHTGRK--------------------------------PYKCKECDKVFGRKCFLTSHQRI 486

  Fly   946 NMFQQPQDGGAPSQVPLFNPFPNPFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLG-- 1008
            :..::|.......::     |....:|.:..|            .|.:|..:   |....|..
Human   487 HTRERPYGCSQCGKI-----FSQKSDLIRHRK------------THTDEKPY---KCNKCGTAFR 531

  Fly  1009 -----GANSLIQGPLLKKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQS 1068
                 .|:.||       .|.::...|:.|||||:..|:||.|.|.|||||||||..|....::|
Human   532 EFSDLTAHFLI-------HSGEKPYECKECGKVFRYKSSLTSHHRIHTGEKPYKCNRCGKVFSRS 589

  Fly  1069 SKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEKHM-----------RKCVVNQGKAAAAANAV 1122
            |.|..|.|.|  ||:..|:|..|...|:..|.|.:|.           .||    |||....:.:
Human   590 SNLVCHQKIH--TGEKPYKCNQCGKVFNQASYLTRHQIIHTGERPYRCSKC----GKAFRGCSGL 648

  Fly  1123 AA 1124
            .|
Human   649 TA 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	11/21 (52%)
		C2H2 Zn finger	719..739	CDD:275368	10/19 (53%)
		zf-H2C2_2	731..756	CDD:338759	15/24 (63%)
		C2H2 Zn finger	747..767	CDD:275368	6/19 (32%)
		zf-C2H2	1029..1050	CDD:333835	11/20 (55%)
		C2H2 Zn finger	1030..1050	CDD:275368	11/19 (58%)
		zf-H2C2_2	1042..1067	CDD:338759	14/24 (58%)
		C2H2 Zn finger	1058..1078	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1088..1106	CDD:275368	6/28 (21%)
ZNF528	XP_006723481.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	272..291	CDD:275368	4/21 (19%)
		COG5048	277..712	CDD:227381	117/535 (22%)
		C2H2 Zn finger	299..319	CDD:275368	4/26 (15%)
		zf-H2C2_2	312..336	CDD:290200	6/30 (20%)
		C2H2 Zn finger	327..347	CDD:275368	2/26 (8%)
		zf-H2C2_2	339..364	CDD:290200	9/32 (28%)
		C2H2 Zn finger	355..375	CDD:275368	10/19 (53%)
		zf-H2C2_2	368..392	CDD:290200	15/23 (65%)
		C2H2 Zn finger	383..403	CDD:275368	6/19 (32%)
		zf-H2C2_2	395..420	CDD:290200	4/24 (17%)
		C2H2 Zn finger	411..431	CDD:275368	2/19 (11%)
		zf-H2C2_2	423..447	CDD:290200	8/69 (12%)
		C2H2 Zn finger	439..459	CDD:275368	7/51 (14%)
		C2H2 Zn finger	467..487	CDD:275368	2/19 (11%)
		C2H2 Zn finger	495..515	CDD:275368	3/36 (8%)
		C2H2 Zn finger	523..543	CDD:275368	4/26 (15%)
		zf-H2C2_2	535..560	CDD:290200	10/31 (32%)
		C2H2 Zn finger	551..571	CDD:275368	11/19 (58%)
		zf-H2C2_2	563..588	CDD:290200	14/24 (58%)
		C2H2 Zn finger	579..599	CDD:275368	7/19 (37%)
		zf-H2C2_2	591..616	CDD:290200	10/26 (38%)
		C2H2 Zn finger	607..627	CDD:275368	6/19 (32%)
		zf-H2C2_2	619..642	CDD:290200	6/26 (23%)
		C2H2 Zn finger	635..655	CDD:275368	6/20 (30%)
		C2H2 Zn finger	663..683	CDD:275368
		zf-H2C2_2	675..700	CDD:290200
		C2H2 Zn finger	691..711	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000