DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9650 and ZNF93

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_112495.2	Gene:	ZNF93 / 81931	HGNCID:	13169	Length:	620	Species:	Homo sapiens

Alignment Length:	411	Identity:	99/411 - (24%)
Similarity:	148/411 - (36%)	Gaps:	91/411 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 YSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPADDQDNQDNQD 781
            |.|..|.|.|::.:.|..|:|.|||||||||..||........|.||..:|......:..:..:.
Human   201 YICEECGKAFKYSSALNTHKRIHTGEKPYKCDKCDKAFIASSTLSKHEIIHTGKKPYKCEECGKA 265

  Fly   782 DGSNADSLETNEADNDEDPNPDESEEELGDGDNDPD----------GDGDLDGEDEDEDELEECE 836
            ...::...:..:....|.|   ...||.|...|...          |        |.....|||.
Human   266 FNQSSTLTKHKKIHTGEKP---YKCEECGKAFNQSSTLTKHKKIHTG--------EKPYVCEECG 319

  Fly   837 DMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQALQESGRKEAA 901
            .....:..|:...||....:..|....|...:....:.:....::.:  :.||  .:|.|:
Human   320 KAFKYSRILTTHKRIHTGEKPYKCNKCGKAFIASSTLSRHEFIHMGK--KHYK--CEECGK---- 376

  Fly   902 AAAAAAAAAADNNNRGGAG-APLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNP 965
              |...::....:.|...| .|...:..|...       :::...:..::...|..|.:..
Human   377 --AFIWSSVLTRHKRVHTGEKPYKCEECGKAF-------KYSSTLSSHKRSHTGEKPYKCE---- 428

  Fly   966 FPNPFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKKESRQRNDTC 1030
                         :.|..:..|..|.::|.:...                    ||..:     |
Human   429 -------------ECGKAFVASSTLSKHEIIHTG--------------------KKPYK-----C 455

  Fly  1031 EFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPF 1095
            |.|||.|...|:||.|::.||||||||||.|..|..|||.||:|.|.|  ||:..|:|..|...|
Human   456 EECGKAFNQSSSLTKHKKIHTGEKPYKCEECGKAFNQSSSLTKHKKIH--TGEKPYKCEECGKAF 518

  Fly  1096 SVPSTLEKHMR--------KC 1108
            :..|||.||.:        ||
Human   519 NQSSTLIKHKKIHTREKPYKC 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	8/21 (38%)
		C2H2 Zn finger	719..739	CDD:275368	7/19 (37%)
		zf-H2C2_2	731..756	CDD:338759	14/24 (58%)
		C2H2 Zn finger	747..767	CDD:275368	6/19 (32%)
		zf-C2H2	1029..1050	CDD:333835	10/20 (50%)
		C2H2 Zn finger	1030..1050	CDD:275368	10/19 (53%)
		zf-H2C2_2	1042..1067	CDD:338759	15/24 (63%)
		C2H2 Zn finger	1058..1078	CDD:275368	11/19 (58%)
		C2H2 Zn finger	1088..1106	CDD:275368	8/17 (47%)
ZNF93	NP_112495.2	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		COG5048	170..612	CDD:227381	99/411 (24%)
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		zf-H2C2_2	215..238	CDD:290200	14/22 (64%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		zf-H2C2_2	244..268	CDD:290200	4/23 (17%)
		C2H2 Zn finger	259..279	CDD:275368	0/19 (0%)
		zf-H2C2_2	272..296	CDD:290200	5/26 (19%)
		C2H2 Zn finger	287..307	CDD:275368	4/19 (21%)
		zf-H2C2_2	300..324	CDD:290200	5/31 (16%)
		C2H2 Zn finger	315..335	CDD:275368	5/19 (26%)
		zf-H2C2_2	328..350	CDD:290200	5/21 (24%)
		C2H2 Zn finger	343..363	CDD:275368	1/19 (5%)
		C2H2 Zn finger	371..391	CDD:275368	4/25 (16%)
		zf-H2C2_2	384..408	CDD:290200	4/30 (13%)
		C2H2 Zn finger	399..419	CDD:275368	1/26 (4%)
		zf-H2C2_2	412..435	CDD:290200	3/39 (8%)
		C2H2 Zn finger	427..447	CDD:275368	4/36 (11%)
		zf-H2C2_2	440..464	CDD:290200	10/48 (21%)
		C2H2 Zn finger	455..475	CDD:275368	10/19 (53%)
		zf-H2C2_2	467..492	CDD:290200	15/24 (63%)
		C2H2 Zn finger	483..503	CDD:275368	11/19 (58%)
		zf-H2C2_2	495..520	CDD:290200	11/26 (42%)
		C2H2 Zn finger	511..531	CDD:275368	8/19 (42%)
		zf-H2C2_2	524..547	CDD:290200	5/16 (31%)
		C2H2 Zn finger	539..559	CDD:275368	1/1 (100%)
		zf-H2C2_2	551..576	CDD:290200
		C2H2 Zn finger	567..587	CDD:275368
		zf-H2C2_2	580..602	CDD:290200
		C2H2 Zn finger	595..615	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000