DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and bcl11a

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001072657.1	Gene:	bcl11a / 780114	XenbaseID:	XB-GENE-486641	Length:	797	Species:	Xenopus tropicalis

Alignment Length:	1195	Identity:	306/1195 - (25%)
Similarity:	413/1195 - (34%)	Gaps:	548/1195 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DSTENDAVAT----QDILTCGACQKAFALSDIVKFIQHKVLQCNKENYGQCATQNPQMDRDAEEG 81
            |..:|..:..    .|:||||.||..|.|.||:.||:||..|||
Frog    29 DEPDNSTLGAGEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCN--------------------- 72

  Fly    82 RPLSLVNRRPSISAPISGRKSAPASAAAAVAAAAAAAAAAAAASSTASGSRIHTPPPSPADLLAD 146
                     .|:....:|.|                                   ||||
Frog    73 ---------GSLCLEKAGDK-----------------------------------PPSP------ 87

  Fly   147 GASSTPKRLVDENDNTTPKDSETGATTLDSNAAPSSPAAIERQSSGDSSCEMEEQQDRQDKQSQP 211
                ||..|                                                  .|.|.|
Frog    88 ----TPSEL--------------------------------------------------KKASNP 98

  Fly   212 KQAKVKQEPYDEEGVNHHQNQDDDDDEEMEERSLAKRPKMELVDAEANTVHTEPSNYTCSTCKTR 276
            .:..::..|            :|||......|.:.  ||.|....:     .|||:|||:|||..
Frog    99 VEVGIQVTP------------EDDDCLSTSSRGIC--PKQENAAGK-----DEPSSYTCTTCKQP 144

  Fly   277 YTSAWRLIQHVQHSHGVKIYVESPGGGATLTVATPAALNNSALALAAAAAAASASGLASPQPAVS 341
            ::|||.|:||.|::||.:||:||..|
Frog   145 FSSAWFLLQHAQNTHGFRIYLESEHG--------------------------------------- 170

  Fly   342 PNPAVTSSAKRSSPLGAAGSTILSTSVSSTCSNSLVNTSGGSISNTSSIGSPQQQQLQLQQQQAQ 406
                        |||                              |..:|.|
Frog   171 ------------SPL------------------------------TPRVGIP------------- 180

  Fly   407 QQQQRVQQQQRENLASAMAAGMRHHPLLPPPEAMHA---NPFQLLRMPLPPALAQAG---NVVPT 465
                           |.:.|   ..|..||...:|.   |||.|||:|...:...:|   ...|.
Frog   181 ---------------SGLGA---ECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLTEGRFPP 227

  Fly   466 VAPLFGRPSPADH---YRMEQLVSEQF---RHHGFNLAAAAAAAQAQFNANGQVVGGVVSGSGEP 524
            ..|||. |.|..|   :|:|:|.:|:.   .||
Frog   228 TPPLFS-PPPRHHLDPHRIERLGAEEMALPTHH-------------------------------- 259

  Fly   525 RPPSSSSSGSQRGSVPPAALPPPSLSSQQQQQQQQAVQQQQQQGAQQQLQSAQQQQQSQQQSQQQ 589
                            |:|.                                          .:.
Frog   260 ----------------PSAF------------------------------------------DRV 266

  Fly   590 QQITPGLVGGAGGSLKLEPQQMDFYSQRLRQLAGTTSPGAGSTVNSSSPSPRQKQSPHFASPSPS 654
            .::.|         |.:||..||| |:|||:|||.|  |:...::.:.|||.|:    ...|.||
Frog   267 LRLNP---------LAMEPPAMDF-SRRLRELAGNT--GSSPPLSPNRPSPMQR----LMQPFPS 315

  Fly   655 QQQQQQLATIPRP--HSLTPPEKLGDASSENGSLGLILASTPRSASTPPSKTGDVSLQEPIAHCY 717
            ..:...|||.|.|  .|:.||                        |.||.|:            .
Frog   316 GNKPPFLATPPLPSLQSVPPP------------------------SQPPVKS------------K 344

  Fly   718 SCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVH---RSPADDQDNQDN 779
            ||.:|.|.|:|::||::|:|:|||||||||..||..|:...||.:||:.|   .||...:
Frog   345 SCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHIHKSSPMTVK----- 404

  Fly   780 QDDG-SNADSLETNEAD-------------------NDEDPNPDESEEELGDGDNDPDGDGDLDG 824
            .||| |.|.|.|...:|                   ||.:..|:..:||          :.:.:.
Frog   405 SDDGLSTASSPEPGTSDLLGSASSVLKSVVAKFKSENDSNLIPENGDEE----------EEEEEE 459

  Fly   825 EDEDEDELEECEDM-------DYK-AEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNI 881
            |:|:|:|.||.||:       ||. ..:|..:...:..::|.:..|      :.|:|...|| .:
Frog   460 EEEEEEEEEEEEDLTETDSRPDYSFGLNLEAARHHENNARSIEERS------MPEVMQSMGL-GM 517

  Fly   882 AQYSEAYKQALQESGRK---------------EAAAAAAAAAAAADNNNRG-----GAGAPLSDK 926
            ..:|:|:.|.|.|..::               ::.|..:....:...|.||     .|...||.|
Frog   518 HHFSDAFHQVLMEKHKRGHLSEPEVQRDTCDEDSVAGESDRIESGTVNGRGCSPGESASGGLSKK 582

  Fly   927 -LNGLPVA------ALRLRDEF-------AKNCNMFQQPQDGGAPSQVPLFNPF-------PNPF 970
             |.|.|.:      .::|..||       ....|::.|...|.|.|: .|..||       .:||
Frog   583 LLLGSPSSLSPFSKRIKLEKEFDLPASAMPNTENVYSQWLAGYAASR-QLKEPFLTFGDSRQSPF 646

  Fly   971 ELSKRM--------------KMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGP---- 1017
            ..|...              :|||| ..|.|..                |.||:...|.||
Frog   647 ASSSEHSSENGSLRFSTPPGEMDGG-ISGRSGT----------------GSGGSTPHISGPGPGR 694

  Fly  1018 LLKKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTG 1082
            ...||.: |:||||:|||:|||||||||||||||||:|||||||:|||||||||||||||||:.|
Frog   695 PSSKEGK-RSDTCEYCGKIFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVG 758

  Fly  1083 KDVYRCRFCDMPFSVPSTLEKHMRK 1107
            ||||:|..|.|||||.|||||||:|
Frog   759 KDVYKCEICQMPFSVYSTLEKHMKK 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	10/21 (48%)
		C2H2 Zn finger	719..739	CDD:275368	9/19 (47%)
		zf-H2C2_2	731..756	CDD:338759	16/24 (67%)
		C2H2 Zn finger	747..767	CDD:275368	8/19 (42%)
		zf-C2H2	1029..1050	CDD:333835	18/20 (90%)
		C2H2 Zn finger	1030..1050	CDD:275368	17/19 (89%)
		zf-H2C2_2	1042..1067	CDD:338759	22/24 (92%)
		C2H2 Zn finger	1058..1078	CDD:275368	18/19 (95%)
		C2H2 Zn finger	1088..1106	CDD:275368	13/17 (76%)
bcl11a	NP_001072657.1	zf-C2H2	345..366	CDD:333835	10/20 (50%)
		C2H2 Zn finger	346..366	CDD:275368	9/19 (47%)
		zf-H2C2_2	358..383	CDD:372612	16/24 (67%)
		C2H2 Zn finger	374..394	CDD:275368	8/19 (42%)
		zf-C2H2	705..726	CDD:333835	18/20 (90%)
		C2H2 Zn finger	706..726	CDD:275368	17/19 (89%)
		zf-H2C2_2	718..743	CDD:372612	22/24 (92%)
		C2H2 Zn finger	734..754	CDD:275368	18/19 (95%)
		C2H2 Zn finger	764..782	CDD:275368	13/17 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	150	1.000	Domainoid score	I4358
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2107
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D121311at33208
OrthoFinder	1	1.000	-	-		FOG0002010
OrthoInspector	1	1.000	-	-		otm49106
Panther	1	1.100	-	-	LDO	PTHR45993
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3003
SonicParanoid	1	1.000	-	-		X1492
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100