DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9650 and ZNF227

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001276095.1	Gene:	ZNF227 / 7770	HGNCID:	13020	Length:	799	Species:	Homo sapiens

Alignment Length:	526	Identity:	123/526 - (23%)
Similarity:	162/526 - (30%)	Gaps:	173/526 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   637 SPSPRQKQSPHFASPSPSQQQQQQLATIPRPHSLTPPEKL------GDASSENGSLGLILASTPR 695
            |.|||....|:..:......|...|.|..|.|   |.|||      ||..:::.
Human   260 SYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIH---PGEKLNRCHESGDCFNKSS----------- 310

  Fly   696 SASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTAC--------DF 752
            ..|...:.||:.|        |.|..|.|.|.....||||.|||||||||||..|        :|
Human   311 FHSYQSNHTGEKS--------YRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNF 367

  Fly   753 ECSHIQKLMKHMRVHRSPADDQDNQDNQDDGSNADSLETNEADNDEDPNPDESEEELGDG----- 812
            :|        |.|||......:..:..:..|.:.:..........|.|   ...||.|.|
Human   368 QC--------HQRVHTEEKPYKCEECGKGFGWSVNLRVHQRVHRGEKP---YKCEECGKGFTQAA 421

  Fly   813 ---------DNDPDGDGDLDGEDEDEDELEECE------DMDYKAE----------DLSVSNRID 852
                     ..:.....|:.|:....:....|.      :..||.|          ||.:..|:.
Human   422 HFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHFRVH 486

  Fly   853 GKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQALQESGRKEAAAAAAAAAAAADNNNRG 917
            ...:..|....|              ...:|.|.........:|.|.......
Human   487 TGEKPYKCKECG--------------KGFSQASNLQVHQNVHTGEKRFKCETC------------ 525

  Fly   918 GAGAPLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNPFPNPFELSKRMKMDGGD 982
            |.|...|.||                  ...|:...|..|.:..:..   ..|..|..:|
Human   526 GKGFSQSSKL------------------QTHQRVHTGEKPYRCDVCG---KDFSYSSNLK----- 564

  Fly   983 WWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKKESRQRNDTCEFCGKVFKNCSNLTVHR 1047
               :.|.:|..|        ||.                       .||.|||.|...|||..|:
Human   565 ---LHQVIHTGE--------KPY-----------------------KCEECGKGFSWRSNLHAHQ 595

  Fly  1048 RSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEKHMR------ 1106
            |.|:||||||||.|..:.:|:.....|.:.|  ||:..|:|..|...||..|.|:.|.|
Human   596 RVHSGEKPYKCEQCDKSFSQAIDFRVHQRVH--TGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEK 658

  Fly  1107 --KCVV 1110
              ||.|
Human   659 PYKCDV 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	10/21 (48%)
		C2H2 Zn finger	719..739	CDD:275368	9/19 (47%)
		zf-H2C2_2	731..756	CDD:338759	18/32 (56%)
		C2H2 Zn finger	747..767	CDD:275368	6/27 (22%)
		zf-C2H2	1029..1050	CDD:333835	11/20 (55%)
		C2H2 Zn finger	1030..1050	CDD:275368	11/19 (58%)
		zf-H2C2_2	1042..1067	CDD:338759	14/24 (58%)
		C2H2 Zn finger	1058..1078	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1088..1106	CDD:275368	7/17 (41%)
ZNF227	NP_001276095.1	KRAB	23..83	CDD:214630
		C2H2 Zn finger	326..346	CDD:275368	9/19 (47%)
		zf-H2C2_2	342..363	CDD:316026	13/20 (65%)
		C2H2 Zn finger	354..374	CDD:275368	6/27 (22%)
		C2H2 Zn finger	382..402	CDD:275368	1/19 (5%)
		COG5048	406..779	CDD:227381	74/350 (21%)
		C2H2 Zn finger	410..430	CDD:275368	4/19 (21%)
		C2H2 Zn finger	438..458	CDD:275368	3/19 (16%)
		C2H2 Zn finger	466..486	CDD:275368	4/19 (21%)
		C2H2 Zn finger	494..514	CDD:275368	3/33 (9%)
		C2H2 Zn finger	522..542	CDD:275368	6/49 (12%)
		C2H2 Zn finger	550..570	CDD:275368	4/30 (13%)
		C2H2 Zn finger	578..598	CDD:275368	11/19 (58%)
		C2H2 Zn finger	606..626	CDD:275368	5/19 (26%)
		C2H2 Zn finger	634..654	CDD:275368	8/19 (42%)
		C2H2 Zn finger	662..682	CDD:275368	2/3 (67%)
		C2H2 Zn finger	690..710	CDD:275368
		C2H2 Zn finger	718..738	CDD:275368
		C2H2 Zn finger	746..766	CDD:275368
		C2H2 Zn finger	774..794	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000