DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9650 and ZNF189

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_003443.2	Gene:	ZNF189 / 7743	HGNCID:	12980	Length:	626	Species:	Homo sapiens

Alignment Length:	467	Identity:	105/467 - (22%)
Similarity:	167/467 - (35%)	Gaps:	92/467 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 YSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPADDQDNQDNQD 781
            |.|:||.|.|...:.||.|||.||||:||:|..|....|..:.|:||.|:|......:.:...:.
Human   204 YECNYCGKTFSVSSTLIRHQRIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKA 268

  Fly   782 DGSNADSLETNEADNDEDPNPDESEEELGDGDNDPDGDGDLDGEDEDEDELEECEDMDYKAEDLS 846
            ....:..:|.......|.|.                             ...:|: ..:....|.
Human   269 FSWKSHLIEHQRTHTGEKPY-----------------------------HCTKCK-KSFSRNSLL 303

  Fly   847 VSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSN-IAQYSEAYKQALQESGRK-----EAAAAAA 905
            |.::.....:.|..        .||....|.||. :.|:.:.:      :|.|     |...:.:
Human   304 VEHQRIHTGERPHK--------CGECGKAFRLSTYLIQHQKIH------TGEKPFLCIECGKSFS 354

  Fly   906 AAAAAADNNNRGGAGAPLSDKLNGLPVAALRLRDEFAKNCNM--FQQPQDGGAPSQVPLFNPFPN 968
            .::...::........|...|..|         ..|::.||:  .|:...|..|.:..
Human   355 RSSFLIEHQRIHTGERPYQCKECG---------KSFSQLCNLTRHQRIHTGDKPHKCE------- 403

  Fly   969 PFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKKESRQRNDTCEFC 1033
              |..|......|  ....|.:|..|..:...:.|.......:.:||..:..||...:   |:.|
Human   404 --ECGKAFSRSSG--LIQHQRIHTREKTYPYNETKESFDPNCSLVIQQEVYPKEKSYK---CDEC 461

  Fly  1034 GKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVP 1098
            ||.|...::|..|:|.|||||||.|.:|..:.::||.|..|.:.|  ||:..|.||.|...||..
Human   462 GKTFSVSAHLVQHQRIHTGEKPYLCTVCGKSFSRSSFLIEHQRIH--TGERPYLCRQCGKSFSQL 524

  Fly  1099 STLEKHM--------RKCVVNQGKAAAAANAVAAAQAAQAAAQHI------QAAAQQAQAVQAQA 1149
            ..|.:|.        .|| ...|||.:..:.:...|......:..      ::.:||...|..|.
Human   525 CNLIRHQGVHTGNKPHKC-DECGKAFSRNSGLIQHQRIHTGEKPYKCEKCDKSFSQQRSLVNHQK 588

  Fly  1150 VQAQAAQQSQQQ 1161
            :.|:...|...:
Human   589 IHAEVKTQETHE 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	11/21 (52%)
		C2H2 Zn finger	719..739	CDD:275368	10/19 (53%)
		zf-H2C2_2	731..756	CDD:338759	13/24 (54%)
		C2H2 Zn finger	747..767	CDD:275368	7/19 (37%)
		zf-C2H2	1029..1050	CDD:333835	8/20 (40%)
		C2H2 Zn finger	1030..1050	CDD:275368	8/19 (42%)
		zf-H2C2_2	1042..1067	CDD:338759	12/24 (50%)
		C2H2 Zn finger	1058..1078	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1088..1106	CDD:275368	7/25 (28%)
ZNF189	NP_003443.2	KRAB	13..54	CDD:396083
		COG5048	138..524	CDD:227381	91/388 (23%)
		C2H2 Zn finger	150..170	CDD:275368
		C2H2 Zn finger	178..198	CDD:275368
		C2H2 Zn finger	206..226	CDD:275368	10/19 (53%)
		C2H2 Zn finger	234..254	CDD:275368	7/19 (37%)
		C2H2 Zn finger	262..282	CDD:275368	1/19 (5%)
		C2H2 Zn finger	290..310	CDD:275368	3/20 (15%)
		C2H2 Zn finger	318..338	CDD:275368	6/19 (32%)
		C2H2 Zn finger	346..366	CDD:275368	1/19 (5%)
		C2H2 Zn finger	374..394	CDD:275368	6/28 (21%)
		C2H2 Zn finger	402..422	CDD:275368	4/30 (13%)
		C2H2 Zn finger	458..478	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..506	CDD:275368	6/19 (32%)
		C2H2 Zn finger	514..534	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..551	CDD:404364	7/25 (28%)
		C2H2 Zn finger	542..562	CDD:275368	5/20 (25%)
		zf-H2C2_2	555..579	CDD:404364	1/23 (4%)
		C2H2 Zn finger	570..590	CDD:275368	4/19 (21%)
		C2H2 Zn finger	601..621	CDD:275368	105/467 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000