DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and Sall4

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_003749680.1	Gene:	Sall4 / 686412	RGDID:	1597672	Length:	1070	Species:	Rattus norvegicus

Alignment Length:	1226	Identity:	256/1226 - (20%)
Similarity:	400/1226 - (32%)	Gaps:	347/1226 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 RQSSGDSSCEMEEQQDRQDKQSQPKQAKVKQEPYDEEGVNHHQNQDDDDDEEMEERSLAKRPKME 252
            |:.:.......||.|..|..| ||.....:....:|.||..:.:.:.|:..|....:..||.:.|
  Rat     4 RKQAKPQHINSEEGQGEQPLQ-QPSPGLAEAPAAEEPGVPVNSSGNGDEASEDPAPAPVKRSRRE 67

  Fly   253 LVDAEANTVHTEPSNYTCSTCKTRYTSAWRLIQHVQHSHGVKIYVESPGGGATLTVATPA-ALNN 316
                         ..:.|:.|...:.|....::|.:                :.|...|. .:|:
  Rat    68 -------------DTHICNKCCAEFFSLSEFMEHKK----------------SCTKNPPVLIMND 103

  Fly   317 SALALAAAAAAASASGLASPQPAVSPNPAVTSSAKRSSPLGAAGSTILSTSVSS-TCSNSLVNTS 380
            |..|:.....:.:..|..|.:..:..|.. :||......||......|.|..:. .....:....
  Rat   104 SEGAVPPEDFSRAVLGSPSNKDGLQENGG-SSSGDLKENLGTDSILYLKTEATQPPAPQDISYLP 167

  Fly   381 GGSISNTS-----------------------------SIGSPQQQQLQLQQQQAQQQQQRVQQQQ 416
            .|.::||:                             ||....:|.|.|||||.||.|...|.:.
  Rat   168 KGKVANTNVTLQALRGTKVAVNQRSTDVPAAPVPAALSIPWILEQILCLQQQQLQQIQLTEQIRV 232

  Fly   417 RENLASAMAAGMRHHPLLPPPEAMHANPFQLLRMPLPPALAQAGNVVPTVAPLFGRPSPADHYRM 481
            :.|:.:|              .|:|:              ..||  ..|:..|      ::|...
  Rat   233 QVNMWAA--------------HALHS--------------GVAG--ADTLKAL------SNHVSQ 261

  Fly   482 EQLVSEQFRHHGFNLAAAAAAAQAQFNANGQVVGGVVSGSGEPRP--PSSSSSGSQRGSVP---- 540
            :..||:|        .:||.|..:|..:|..:....:..:..|..  ||::||.|. |..|
  Rat   262 QVSVSQQ--------VSAAVALLSQKASNPTLSLDALKQAKLPHAAVPSTASSLSS-GFTPFALK 317

  Fly   541 --------------PAALPPPSLSSQQQQQQQQAV---QQQQQQGAQQQLQSAQQQQQSQQQSQQ 588
                          |.||.|.:..|...|.....|   |.::.:|..|.|.:      |...::.
  Rat   318 PDGTRVLPNFMSRLPNALLPQTPGSVLLQSPFSTVTLDQSKKGKGKPQNLSA------SMLDAKT 376

  Fly   589 QQQITPG--------LVGGAGGSLKL--------EPQQMDFYSQRLR------------------ 619
            :.::..|        .|.|...||::        .|........|..
  Rat   377 KDEVVLGKHKCRYCSKVFGTDSSLQIHLRSHTGERPYVCPVCGHRFTTKGNLKVHFHRHPQVKAN 441

  Fly   620 -QLAGT--TSPGAGSTVNSSSPSPRQKQSPHFASPSPSQQQQQQLA--TIPRPHSLTP----PEK 675
             ||..|  ...||.||            |||:|.|.|....:..|:  |.|.|.:.||    |:|
  Rat   442 PQLFATEFQDKGASST------------SPHYALPVPIPVDESSLSVDTEPVPVTGTPSIGLPQK 494

  Fly   676 LGDASSEN------GSL--------------GL------ILASTPRS-----ASTPPSKTGDVSL 709
            |  .|..|      |||              ||      ::.:.||:     ...|.|.:..:.|
  Rat   495 L--TSGPNPKDLMGGSLPNDIQPGPSPESEVGLPLLGAGMMRNPPRAGGFQGTGAPESGSETLKL 557

  Fly   710 QEPIAHC-------YSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVH 767
            |:.:.:.       ..|..|.:....:::|.:|.||||||:|::|..|....|....|..|:.||
  Rat   558 QQLVENIDKATTDPNECLICHRVLSCQSSLKMHYRTHTGERPFQCKICGRAFSTKGNLKTHLGVH 622

  Fly   768 RSPADDQDNQD---NQDDGSNADSLETN-------EADN---DEDPNPDESEEELGDGDNDPDGD 819
            |:....:....   .|...:||..|:.:       :..|   .|.|......|.:...:|  .|.
  Rat   623 RTNMAVKTQHSCPICQKKFTNAVMLQQHIRMHMGGQIPNTPLPESPCDFTVPEPMAVSEN--GGG 685

  Fly   820 GDLDGEDEDED-ELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSL---VGELMDKFGLSN 880
            ..:..||..|. |.||....|......:||..:.|       |...:.||   |...:|..|...
  Rat   686 SGVCQEDAVEGMEAEEACIQDVPGGPSTVSAPLPG-------THLASPSLGFPVMAPLDAQGRGA 743

  Fly   881 IAQYSEAYKQALQESGRKEAAAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRLRDEFAKNC 945
            :...      |||....:|:.:..|..:...::          |..|.|......|..|.....|
  Rat   744 LPAL------ALQRQSSRESGSLEAGDSCLTND----------SSSLMGDQECPSRSPDATETMC 792

  Fly   946 NMFQQPQDGGAPSQVPLFNPFPNPFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGA 1010
            .....|.:..|.| |...:|..:..|..:..::|......:.....|.:..|..::: |....|.
  Rat   793 YQAVSPANSQAGS-VKSRSPDGHKAEGVESCRVDTEGRTSLPSTFIRAQPTFVKVEV-PGSFVGP 855

  Fly  1011 NSLIQG--PLLKKESRQRND----TCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSS 1069
            .|:..|  |||..:...|..    :|..|||.|.:.|.|.:|.|:||||||:.|.:|:.|.....
  Rat   856 PSVPSGMTPLLASQQPPRRQAKQHSCTRCGKNFSSASALQIHERTHTGEKPFVCNICARAFTTKG 920

  Fly  1070 KLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEKHMRKCVVNQGKAAAAANAVAAAQAAQAAAQH 1134
            .|..|..|||.......|                         |:..|..|.:||..|....|..
  Rat   921 NLKVHYMTHGTNNNSARR-------------------------GRKLAIENTMAALGAEGKRAPE 960

  Fly  1135 IQAAAQQAQAVQAQAVQAQAAQQSQ----------QQQQQLSPMGVVGYP--------PQFVSGH 1181
            :     ..:.:.:..|....|..:|          .:..::|.:...|.|        ...||..
  Rat   961 V-----FPKELLSPTVSVDPATWNQYTSVLNGGLAMKTNEISVIQSGGIPTLPVSLGASSVVSNP 1020

  Fly  1182 NLS-LPGSVSGDNDSNASSSMTGVHPISLKEEAXLFSGFPVPLAPPPPLQQHQ-PH 1235
            .|| |.||.:|     .|.:|:|....:|::..            |..:.:|| ||
  Rat  1021 TLSKLDGSQTG-----GSGAMSGAMSGNLEKPGV-----------PDGVAKHQFPH 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	5/21 (24%)
		C2H2 Zn finger	719..739	CDD:275368	5/19 (26%)
		zf-H2C2_2	731..756	CDD:338759	11/24 (46%)
		C2H2 Zn finger	747..767	CDD:275368	5/19 (26%)
		zf-C2H2	1029..1050	CDD:333835	9/20 (45%)
		C2H2 Zn finger	1030..1050	CDD:275368	9/19 (47%)
		zf-H2C2_2	1042..1067	CDD:338759	12/24 (50%)
		C2H2 Zn finger	1058..1078	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1088..1106	CDD:275368	0/17 (0%)
Sall4	XP_003749680.1	COG5048	385..>676	CDD:227381	67/304 (22%)
		zf-C2H2	385..407	CDD:278523	4/21 (19%)
		C2H2 Zn finger	387..407	CDD:275368	4/19 (21%)
		zf-H2C2_2	399..424	CDD:290200	4/24 (17%)
		C2H2 Zn finger	415..435	CDD:275368	1/19 (5%)
		C2H2 Zn finger	574..594	CDD:275368	5/19 (26%)
		zf-H2C2_2	586..611	CDD:290200	11/24 (46%)
		C2H2 Zn finger	602..622	CDD:275368	5/19 (26%)
		zf-C2H2	632..654	CDD:278523	4/21 (19%)
		C2H2 Zn finger	634..654	CDD:275368	4/19 (21%)
		lambda-1	795..>900	CDD:212564	25/106 (24%)
		COG5048	856..>935	CDD:227381	29/78 (37%)
		C2H2 Zn finger	881..901	CDD:275368	9/19 (47%)
		zf-H2C2_2	893..918	CDD:290200	12/24 (50%)
		C2H2 Zn finger	909..929	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000