DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and bcl11aa

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001035481.1	Gene:	bcl11aa / 678650	ZFINID:	ZDB-GENE-060421-4643	Length:	829	Species:	Danio rerio

Alignment Length:	1186	Identity:	313/1186 - (26%)
Similarity:	409/1186 - (34%)	Gaps:	524/1186 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 QDILTCGACQKAFALSDIVKFIQHKVLQCNKENYGQCATQNPQMDRDAEEGRPLSLVNRRPSISA 95
            ||:||||.||..|.|.||:.||:||..|||    |...     ||:..::
Zfish    45 QDLLTCGQCQMNFPLGDILIFIEHKRKQCN----GTLC-----MDKAVDK--------------- 85

  Fly    96 PISGRKSAPASAAAAVAAAAAAAAAAAAASSTASGSRIHTPPPSPADLLADGASSTPKRLVDEND 160
                                                     ||||
Zfish    86 -----------------------------------------PPSP-------------------- 89

  Fly   161 NTTPKDSETGATTLDSNAAPSSPAAIERQSSGDSSCEMEEQQDRQDKQSQPKQAKVKQEPYDEEG 225
                                         |.|:..           :.|.|.:..|:..|
Zfish    90 -----------------------------SHGELR-----------RASNPVEVGVQVTP----- 109

  Fly   226 VNHHQNQDDDDDEEMEERSLAKRPKMELVDAEANTVHTEPSNYTCSTCKTRYTSAWRLIQHVQHS 290
                   :|||......|.:.  ||.|.:     |...|||:|||:|||..::|||.|:||.|::
Zfish   110 -------EDDDCLSTSSRGIC--PKQENI-----TGKDEPSSYTCTTCKQPFSSAWFLLQHAQNT 160

  Fly   291 HGVKIYVESPGGGATLTVATPAALNNSALALAAAAAAASASGLASPQPAVSPNPAVTSSAKRSSP 355
            ||.:||:||                                                   :|.||
Zfish   161 HGFRIYLES---------------------------------------------------ERGSP 174

  Fly   356 LGAAGSTILSTSVSSTCSNSLVNTSGGSISNTSSIGSPQQQQLQLQQQQAQQQQQRVQQQQRENL 420
            |                              |..:|:|
Zfish   175 L------------------------------TPRVGAP--------------------------- 182

  Fly   421 ASAMAAGMRHHPLLPPPEAMHANPFQLLRMPL-----PPALAQAGNVVPTVAPLFGRPSPADH-- 478
             |.|.|.....|.|........:||.|||:|.     ||  .:.|...|| .|||. |.|..|
Zfish   183 -SGMGADCSSQPPLHGIHLPEGSPFNLLRIPNSGRDGPP--LREGRFPPT-PPLFS-PPPRHHLD 242

  Fly   479 -YRMEQLVSEQF---RHHGFNLAAAAAAAQAQFNANGQVVGGVVSGSGEPRPPSSSSSGSQRGSV 539
             :|||.|..|:.   .||                                  ||:.....:...:
Zfish   243 PHRMEHLSPEELALATHH----------------------------------PSAFDRVLRLNPI 273

  Fly   540 PPAALPPPSLSSQQQQQQQQAVQQQQQQGAQQQLQSAQQQQQSQQQSQQQQQITPGLVGGAGGSL 604
            |
Zfish   274 P---------------------------------------------------------------- 274

  Fly   605 KLEPQQMDFYSQRLRQLAGTTSPGAGST--VNSSSPSPRQKQSPHFASPSPSQQQQQQLATIPRP 667
             ::|..||| |:|||:|||.||   |||  ::.:.|||.|:....|           |..|.| |
Zfish   275 -MDPPAMDF-SRRLRELAGNTS---GSTPPLSPNRPSPMQRLLQPF-----------QSGTKP-P 322

  Fly   668 HSLTPPEKLGDASSENGSLGLILASTP---RSASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFE 729
            ...|||  |....|.:||     .|||   ...|..|.||            .||.:|.|.|:|:
Zfish   323 FLSTPP--LPSMQSPSGS-----QSTPTPLNQQSNTPMKT------------KSCEFCGKTFKFQ 368

  Fly   730 NNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPADDQDNQDNQDDG-SNADSLETNE 793
            :|||:|:|:|||||||||..||..|:...||.:||:.|.:.:  .......||| |.|.|.|...
Zfish   369 SNLIVHRRSHTGEKPYKCHLCDHACTQASKLKRHMKTHMNKS--SPTTVKSDDGLSTASSPEPGT 431

  Fly   794 AD--------------------------NDEDPNPDESEEELGDGDNDPDGDG---DLDGEDEDE 829
            :|                          |.|:...:|.|||..:.:.:.:.:|   :|:.|.|.|
Zfish   432 SDLVGSASNALKSVVAKFKSENDRMIPENGEEEEEEEEEEEEEEEEEEEEEEGEEEELERERERE 496

  Fly   830 DELEECEDMDYKAEDLSVSNRIDG----KSQSPKTTSSGATSLVGELMDKFGL-SNIAQYSEAYK 889
            .|.|...|.|....:...|..:..    ::...:....|....:.|:|...|| :::..||||:.
Zfish   497 RERERERDRDGGRNNYHFSLNLQAARHHENNGGRLGEDGIPRSLPEVMQGMGLAASMQHYSEAFH 561

  Fly   890 Q----ALQ----------------ESGRKEAAAAAAAAAAAADNNNRG-----GAGAPLSDK-LN 928
            |    ||.                ||.|.:....:|.       |.||     .|...||.| |.
Zfish   562 QHKRGALNSDNDAHRDMCDEDSALESDRVDEGCGSAI-------NGRGSSPSESASVGLSKKLLL 619

  Fly   929 GLPVA------ALRLRDEFAKNC-------NMFQQPQDGGAPSQVPLFNPFPN-------PFELS 973
            |.|.:      .::|..:|..:.       |::.|...|.|.|: .|.:||.|       ||..|
Zfish   620 GSPSSLSPFSKRIKLEKDFDLSTPTIPNTENVYSQWLAGYAASR-QLKDPFLNFGDSRQSPFASS 683

  Fly   974 KRMKMDGGDW----------WGMSQALHRNEALFENLKLKPLGLGGANSLIQGP--LLKKESRQR 1026
            .....:.|..          .|:|..             ...|.||:...:.||  ...|:.| |
Zfish   684 SEHSSENGSLRFSTPPGDLDGGVSGR-------------SGTGSGGSTPHLGGPGRPSSKDGR-R 734

  Fly  1027 NDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFC 1091
            .||||||||||||||||||||||||||:|||||||:|||||||||||||||||:.|||||:|..|
Zfish   735 TDTCEFCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVGKDVYKCEIC 799

  Fly  1092 DMPFSVPSTLEKHMRK 1107
            .|||||.|||||||:|
Zfish   800 QMPFSVYSTLEKHMKK 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	11/21 (52%)
		C2H2 Zn finger	719..739	CDD:275368	10/19 (53%)
		zf-H2C2_2	731..756	CDD:338759	17/24 (71%)
		C2H2 Zn finger	747..767	CDD:275368	8/19 (42%)
		zf-C2H2	1029..1050	CDD:333835	20/20 (100%)
		C2H2 Zn finger	1030..1050	CDD:275368	19/19 (100%)
		zf-H2C2_2	1042..1067	CDD:338759	22/24 (92%)
		C2H2 Zn finger	1058..1078	CDD:275368	18/19 (95%)
		C2H2 Zn finger	1088..1106	CDD:275368	13/17 (76%)
bcl11aa	NP_001035481.1	COG5048	326..>411	CDD:227381	42/105 (40%)
		zf-C2H2	357..378	CDD:278523	11/20 (55%)
		C2H2 Zn finger	358..378	CDD:275368	10/19 (53%)
		zf-H2C2_2	370..395	CDD:290200	17/24 (71%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2	737..758	CDD:278523	20/20 (100%)
		C2H2 Zn finger	738..758	CDD:275368	19/19 (100%)
		zf-H2C2_2	750..775	CDD:290200	22/24 (92%)
		C2H2 Zn finger	766..786	CDD:275368	18/19 (95%)
		C2H2 Zn finger	796..814	CDD:275368	13/17 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4481
eggNOG	1	0.900	-	-		E33208_3BE4M
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2152
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D121311at33208
OrthoFinder	1	1.000	-	-		FOG0002010
OrthoInspector	1	1.000	-	-		otm25193
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45993
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3003
SonicParanoid	1	1.000	-	-		X1492
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	11.050