DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9650 and Zfp442

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_011238043.1	Gene:	Zfp442 / 668923	MGIID:	3651999	Length:	673	Species:	Mus musculus

Alignment Length:	437	Identity:	110/437 - (25%)
Similarity:	156/437 - (35%)	Gaps:	104/437 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   715 HCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPADDQDNQDN 779
            |...|....|.|....||.|:||||||||||:|..||....|...|.:|.|:|......:.||..
Mouse   187 HTVKCKQSGKDFACYTNLQIYQRTHTGEKPYECIFCDKTFIHHSHLERHERIHTGEKPYECNQCG 251

  Fly   780 QDDGSNADSLETNEADNDEDPNPDESEE-------ELGDGDNDPDGDGDLDGEDEDEDELEECED 837
            :....|: ||:.::..:..: .|.|.::       :.|...:.....|      |...|.:.|..
Mouse   252 KAFSQNS-SLQLHKRTHTGE-KPYECKQCGKSFACQSGLQQHKKTHHG------EKSYECKRCGK 308

  Fly   838 MDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDK-FGL-------SNIAQYSEAYKQALQE 894
            ......||          |..|.|.:|..|......|| |.|       ..|....:.||  ..:
Mouse   309 AFACQSDL----------QQHKRTHTGEKSYECNQCDKAFALRCHLRRHQRIHTVEKPYK--CNQ 361

  Fly   895 SGRKEAAAAAAAAAAAADNNN-----RGGAGAPLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDG 954
            .|:           ..|.:|:     |...|..        |....:....||...::....:..
Mouse   362 CGK-----------FFAQSNHFVRHKRTHTGEK--------PYECNQCDKAFACQTSLLYHKRTH 407

  Fly   955 GAPSQVPLFNPFPNPFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLL 1019
            .. .::.:.|.....|.|...::        :.:..|..|        ||.|
Mouse   408 SG-EKLYVCNECGKAFVLQSYLQ--------IHKRTHTGE--------KPFG------------- 442

  Fly  1020 KKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKD 1084
                      |:.|.|.|...|:|..|:|:|||||||:||.|..|.|.:|.|..|.|||  ||:.
Mouse   443 ----------CDQCDKAFAQNSHLLTHKRTHTGEKPYECEQCGKAFASNSNLQVHKKTH--TGEK 495

  Fly  1085 VYRCRFCDMPFSVPSTLEKHMRKCVVNQGKAAAAANAVAAAQAAQAA 1131
            .|.|:.|...|...|.|:||.|   .:.|:.....|....|.|.||:
Mouse   496 PYECKQCGKAFGFQSGLQKHKR---THTGEKPYECNQCDKAFACQAS 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	8/21 (38%)
		C2H2 Zn finger	719..739	CDD:275368	8/19 (42%)
		zf-H2C2_2	731..756	CDD:338759	16/24 (67%)
		C2H2 Zn finger	747..767	CDD:275368	7/19 (37%)
		zf-C2H2	1029..1050	CDD:333835	8/20 (40%)
		C2H2 Zn finger	1030..1050	CDD:275368	8/19 (42%)
		zf-H2C2_2	1042..1067	CDD:338759	14/24 (58%)
		C2H2 Zn finger	1058..1078	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1088..1106	CDD:275368	7/17 (41%)
Zfp442	XP_011238043.1	KRAB	10..50	CDD:366587
		C2H2 Zn finger	83..103	CDD:275368
		C2H2 Zn finger	140..159	CDD:275368
		C2H2 Zn finger	167..183	CDD:275368
		C2H2 Zn finger	191..211	CDD:275368	8/19 (42%)
		COG5048	215..595	CDD:227381	96/409 (23%)
		C2H2 Zn finger	219..239	CDD:275368	7/19 (37%)
		C2H2 Zn finger	247..267	CDD:275368	5/20 (25%)
		C2H2 Zn finger	275..295	CDD:275368	1/19 (5%)
		C2H2 Zn finger	303..323	CDD:275368	5/29 (17%)
		C2H2 Zn finger	331..351	CDD:275368	4/19 (21%)
		C2H2 Zn finger	359..379	CDD:275368	4/30 (13%)
		C2H2 Zn finger	387..407	CDD:275368	2/19 (11%)
		C2H2 Zn finger	415..435	CDD:275368	3/27 (11%)
		C2H2 Zn finger	443..463	CDD:275368	8/19 (42%)
		C2H2 Zn finger	471..491	CDD:275368	9/19 (47%)
		C2H2 Zn finger	499..519	CDD:275368	8/22 (36%)
		C2H2 Zn finger	527..547	CDD:275368	5/13 (38%)
		C2H2 Zn finger	555..575	CDD:275368
		SFP1	<577..660	CDD:227516
		C2H2 Zn finger	583..603	CDD:275368
		C2H2 Zn finger	611..631	CDD:275368
		C2H2 Zn finger	639..658	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000