DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and ZFP62

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001166109.1	Gene:	ZFP62 / 643836	HGNCID:	23241	Length:	900	Species:	Homo sapiens

Alignment Length:	627	Identity:	133/627 - (21%)
Similarity:	211/627 - (33%)	Gaps:	149/627 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   521 SGEPRPPSS--SSSGSQRGSVPPAALPPPS--------LSSQQQQQQQQAVQQQQQQGAQQQLQS 575
            |.|...|:.  .:.|:.....|....|.|.        ..|:.:.||::.|:.:.::. :..::.
Human     7 STEDEEPTEEYENVGNAASKWPKVEDPMPESKVGDTCVWDSKVENQQKKPVENRMKED-KSSIRE 70

  Fly   576 AQQQQQSQQQSQQQQQITPGLVGGAG-GSLKLEPQQMDFYSQRLRQLAGTTSPGAGSTVNSSSPS 639
            |..:.:|....:.:|:      |.|. .||.|.||.:...:..:.|..........:...:|.||
Human    71 AISKAKSTANIKTEQE------GEASEKSLHLSPQHITHQTMPIGQRGSEQGKRVENINGTSYPS 129

  Fly   640 PRQKQSPHFASPSPSQQQQQQLATIPRPHSLTPPEKLGDASSENGSLGLILASTPRSASTPPSKT 704
            .:||.:                 .:.:.|..   ::.|.:...|..|
Human   130 LQQKTN-----------------AVKKLHKC---DECGKSFKYNSRL------------------ 156

  Fly   705 GDVSLQEPIAHC----YSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMR 765
                :|..|.|.    |.|..|...||..::|.:|:|.|||||||||..|.........|:.|..
Human   157 ----VQHKIMHTGEKRYECDDCGGTFRSSSSLRVHKRIHTGEKPYKCEECGKAYMSYSSLINHKS 217

  Fly   766 VHRSPADDQDNQDNQDDGSNADSLETNEADNDEDPNPDESEEELGDGDNDPDGDGDLDGEDEDED 830
            .|    ..:.|....:.|.:.:  .::..|..:..:..|...|.|
Human   218 TH----SGEKNCKCDECGKSFN--YSSVLDQHKRIHTGEKPYECG-------------------- 256

  Fly   831 ELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQALQES 895
               ||......:..|.|..||....:..:....|.|     ..:..||       ..:|:.  .:
Human   257 ---ECGKAFRNSSGLRVHKRIHTGEKPYECDICGKT-----FSNSSGL-------RVHKRI--HT 304

  Fly   896 GRKEAAAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQV 960
            |.|.........|................||    |...    ||..|:.|.      .....|.
Human   305 GEKPYECDECGKAFITCRTLLNHKSIHFGDK----PYKC----DECEKSFNY------SSLLIQH 355

  Fly   961 PLFNPFPNPFE---------------LSKRM-------KMD-GGDWWGMSQALHRNEALFENLKL 1002
            .:.:....|:|               :.||:       |.| .|..:..|..|..::::....|.
Human   356 KVIHTGEKPYECDECGKAFRNSSGLIVHKRIHTGEKPYKCDVCGKAFSYSSGLAVHKSIHPGKKA 420

  Fly  1003 KPLGLGGANSLIQGPLLKK---ESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYA 1064
            ......|.:......||:.   .:.:|...|:.|||.|:|.:.|.||||.|||||||||::|..|
Human   421 HECKECGKSFSYNSLLLQHRTIHTGERPYVCDVCGKTFRNNAGLKVHRRLHTGEKPYKCDVCGKA 485

  Fly  1065 CAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEKHMR 1106
            ....|.|..|...|  .|:..|:|.:|:..|:..|.||:|.|
Human   486 YISRSSLKNHKGIH--LGEKPYKCSYCEKSFNYSSALEQHKR 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	8/21 (38%)
		C2H2 Zn finger	719..739	CDD:275368	7/19 (37%)
		zf-H2C2_2	731..756	CDD:338759	13/24 (54%)
		C2H2 Zn finger	747..767	CDD:275368	4/19 (21%)
		zf-C2H2	1029..1050	CDD:333835	11/20 (55%)
		C2H2 Zn finger	1030..1050	CDD:275368	11/19 (58%)
		zf-H2C2_2	1042..1067	CDD:338759	16/24 (67%)
		C2H2 Zn finger	1058..1078	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1088..1106	CDD:275368	7/17 (41%)
ZFP62	NP_001166109.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97		18/96 (19%)
		COG5048	125..552	CDD:227381	111/502 (22%)
		C2H2 Zn finger	143..163	CDD:275368	5/44 (11%)
		C2H2 Zn finger	171..191	CDD:275368	7/19 (37%)
		C2H2 Zn finger	199..219	CDD:275368	4/19 (21%)
		C2H2 Zn finger	227..247	CDD:275368	2/21 (10%)
		C2H2 Zn finger	255..275	CDD:275368	6/42 (14%)
		C2H2 Zn finger	283..303	CDD:275368	5/33 (15%)
		C2H2 Zn finger	311..331	CDD:275368	1/19 (5%)
		C2H2 Zn finger	339..359	CDD:275368	5/29 (17%)
		C2H2 Zn finger	367..387	CDD:275368	2/19 (11%)
		C2H2 Zn finger	395..415	CDD:275368	4/19 (21%)
		C2H2 Zn finger	423..443	CDD:275368	3/19 (16%)
		COG5048	447..860	CDD:227381	37/81 (46%)
		C2H2 Zn finger	451..471	CDD:275368	11/19 (58%)
		C2H2 Zn finger	479..499	CDD:275368	6/19 (32%)
		C2H2 Zn finger	507..527	CDD:275368	8/19 (42%)
		C2H2 Zn finger	535..555	CDD:275368
		C2H2 Zn finger	563..583	CDD:275368
		C2H2 Zn finger	591..611	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		C2H2 Zn finger	647..667	CDD:275368
		C2H2 Zn finger	675..695	CDD:275368
		C2H2 Zn finger	703..723	CDD:275368
		C2H2 Zn finger	731..751	CDD:275368
		C2H2 Zn finger	759..779	CDD:275368
		C2H2 Zn finger	787..807	CDD:275368
		C2H2 Zn finger	815..834	CDD:275368
		C2H2 Zn finger	842..862	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000