DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and SALL1

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_002959.2	Gene:	SALL1 / 6299	HGNCID:	10524	Length:	1324	Species:	Homo sapiens

Alignment Length:	1279	Identity:	250/1279 - (19%)
Similarity:	393/1279 - (30%)	Gaps:	418/1279 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TQDILTCG-ACQKAFALSDIVKFIQHKVLQCNKENYGQCATQNP--------------------- 72
            ::|...|| .|.:.|.|||:   :.|| ..|.|........:||
Human    39 SKDAHVCGRCCAEFFELSDL---LLHK-KNCTKNQLVLIVNENPASPPETFSPSPPPDNPDEQMN 99

  Fly    73 -------QMD-RDAEEGRPLSLVNRRPS--ISAPI-----SGRKSAPASAAAAVAAAAAAAAAAA 122
                   |:| .|..|...|   :|..|  :.||:     ||..|...|:.|..:::::::::..
Human   100 DTVNKTDQVDCSDLSEHNGL---DREESMEVEAPVANKSGSGTSSGSHSSTAPSSSSSSSSSSGG 161

  Fly   123 AASSTASGSRIHTPPPSPADLLADGASSTPKRLVDENDNTTPKDSETGATTLDSNAAPSSPAAIE 187
            ..||:...|.|.|..|...||                            |||.:.:..:|...||
Human   162 GGSSSTGTSAITTSLPQLGDL----------------------------TTLGNFSVINSNVIIE 198

  Fly   188 RQSSGDSSCEMEEQQDRQDKQSQPKQAKVKQEPYDEEGVNHHQNQDDDDDEEMEERSLAKRPKME 252
            ...|...:.....|:.|....|..|                                ||....||
Human   199 NLQSTKVAVAQFSQEARCGGASGGK--------------------------------LAVPALME 231

  Fly   253 -LVDAEANTVHTEPSNYTCSTCKTRYTSAWRLIQHVQH------SHGVKIYV-ESPGGGATLTVA 309
             |:..:...:|                 ..:||:.::|      |....:.. .||..|...|.|
Human   232 QLLALQQQQIH-----------------QLQLIEQIRHQILLLASQNADLPTSSSPSQGTLRTSA 279

  Fly   310 TPAALNNSALALAAAAAAASASGLASPQPAVSPNPAVTSSAKRSSPLGAAGSTIL-STSVSSTCS 373
            .|.:..:|.|:...||||..|..|||...::|   .|........|..::|:||: |.|.||...
Human   280 NPLSTLSSHLSQQLAAAAGLAQSLASQSASIS---GVKQLPPIQLPQSSSGNTIIPSNSGSSPNM 341

  Fly   374 NSLVNTSGGSISNTSSIGSPQQQQLQLQQQQAQQQQQRVQQQQRENLASAMAAGMRHHPLLPPPE 438
            |.|          .:::.:|..:::......:......|........|.:.......:||||
Human   342 NIL----------AAAVTTPSSEKVASSAGASHVSNPAVSSSSSPAFAISSLLSPASNPLLP--- 393

  Fly   439 AMHANPFQLLRMPLP------------PALAQAGNVVPTVAPLFGRPSPADHYRMEQLVSEQFRH 491
             ..|:...:...|||            .||||.....|.....|...|.:|         |.|..
Human   394 -QQASANSVFPSPLPNIGTTAEDLNSLSALAQQRKSKPPNVTAFEAKSTSD---------EAFFK 448

  Fly   492 HGFNLAA-------------AAAAAQAQFNANGQVVGGVVSGSG------------------EPR 525
            |.....|             .:...:..|..|  :.|...|..|                  .|.
Human   449 HKCRFCAKVFGSDSALQIHLRSHTGERPFKCN--ICGNRFSTKGNLKVHFQRHKEKYPHIQMNPY 511

  Fly   526 PPSS------SSSGSQRG-SVPP--------------------AALP-PPSLSSQQQQQQQQAVQ 562
            |...      :|:|...| |:||                    ..|| ||:|.|
Human   512 PVPEHLDNIPTSTGIPYGMSIPPEKPVTSWLDTKPVLPTLTTSVGLPLPPTLPS----------- 565

  Fly   563 QQQQQGAQQQLQSAQQQQQSQQQSQQQQQITPGLVGGAGGSLKLEPQQMDFYSQRLRQLAGTTSP 627
                     .:...:.::.:...........||.|....|.    |:      ...|.|.|....
Human   566 ---------LIPFIKTEEPAPIPISHSATSPPGSVKSDSGG----PE------SATRNLGGLPEE 611

  Fly   628 GAGST-------------VNSSSP--------SPRQKQSP-----HFASPSPSQQQQQQLATIPR 666
            ..|||             |.:|.|        ||.....|     .|.:|......:|..|..|.
Human   612 AEGSTLPPSGGKSEESGMVTNSVPTASSSVLSSPAADCGPAGSATTFTNPLLPLMSEQFKAKFPF 676

  Fly   667 PHSLTPPEKLGDASSENGSLGLILASTPRSASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFENN 731
            ...|...:     :||...|..::.:..:.|:.|                ..|..|.:....::.
Human   677 GGLLDSAQ-----ASETSKLQQLVENIDKKATDP----------------NECIICHRVLSCQSA 720

  Fly   732 LIIHQRTHTGEKPYKCTAC-------------------------DFECSHIQK-------LMKHM 764
            |.:|.||||||:|:||..|                         ...|...||       |.:|:
Human   721 LKMHYRTHTGERPFKCKICGRAFTTKGNLKTHYSVHRAMPPLRVQHSCPICQKKFTNAVVLQQHI 785

  Fly   765 RVH------RSPADDQDNQDNQDDGSNADSLETNEADNDEDPNPDESEEELGDGDNDPDGDGDLD 823
            |:|      .:|..|..::..:.|..:.|....::.||..|.|
Human   786 RMHMGGQIPNTPVPDSYSESMESDTGSFDEKNFDDLDNFSDEN---------------------- 828

  Fly   824 GEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAY 888
                    :|:|.:........|.....|..|.||......:.:.:...|.........|...:.
Human   829 --------MEDCPEGSIPDTPKSADASQDSLSSSPLPLEMSSIAALENQMKMINAGLAEQLQASL 885

  Fly   889 KQALQESGRKEAAAAAAAAAAAADNNNRGGAGAP-LSDKLNGL-PVAALRLRDEFAKNCNMFQQP 951
            |..  |:|..|.......:::...:.....||:| :|:..:.: .::......||.|:.::.::|
Human   886 KSV--ENGSIEGDVLTNDSSSVGGDMESQSAGSPAISESTSSMQALSPSNSTQEFHKSPSIEEKP 948

  Fly   952 QDGGAPSQVPL-FNPFPNPFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQ 1015
            | ...||:... .:|.|          ::||       ||....:..|.: :|...||     |.
Human   949 Q-RAVPSEFANGLSPTP----------VNGG-------ALDLTSSHAEKI-IKEDSLG-----IL 989

  Fly  1016 GPLLKKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGR 1080
            .| .:...:.:|..|:.|||.|...|.|.:|.||||.|:|:.|.:|:...:....|.:||.||..
Human   990 FP-FRDRGKFKNTACDICGKTFACQSALDIHYRSHTKERPFICTVCNRGFSTKGNLKQHMLTHQM 1053

  Fly  1081 TGKDVYRCRFCDMPFSVPSTLEKHMRKCVVNQGKAAAAANAVAA 1124
            .              .:||.|.:.......||..|...||::::
Human  1054 R--------------DLPSQLFEPSSNLGPNQNSAVIPANSLSS 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	5/21 (24%)
		C2H2 Zn finger	719..739	CDD:275368	5/19 (26%)
		zf-H2C2_2	731..756	CDD:338759	13/49 (27%)
		C2H2 Zn finger	747..767	CDD:275368	8/51 (16%)
		zf-C2H2	1029..1050	CDD:333835	9/20 (45%)
		C2H2 Zn finger	1030..1050	CDD:275368	9/19 (47%)
		zf-H2C2_2	1042..1067	CDD:338759	10/24 (42%)
		C2H2 Zn finger	1058..1078	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1088..1106	CDD:275368	3/17 (18%)
SALL1	NP_002959.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..102		2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..172		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..336		5/18 (28%)
		C2H2 Zn finger	451..471	CDD:275368	1/19 (5%)
		zf-H2C2_2	463..488	CDD:290200	3/26 (12%)
		C2H2 Zn finger	479..499	CDD:275368	4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..646		15/78 (19%)
		C2H2 Zn finger	708..728	CDD:275368	5/19 (26%)
		zf-H2C2_2	720..745	CDD:290200	12/24 (50%)
		C2H2 Zn finger	736..756	CDD:275368	2/19 (11%)
		zf-C2H2	766..788	CDD:278523	6/21 (29%)
		C2H2 Zn finger	768..788	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..856		14/95 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..963		12/69 (17%)
		C2H2 Zn finger	1003..1023	CDD:275370	9/19 (47%)
		zf-H2C2_2	1015..1040	CDD:290200	10/24 (42%)
		zf-C2H2	1029..1051	CDD:278523	5/21 (24%)
		C2H2 Zn finger	1031..1051	CDD:275370	5/19 (26%)
		lambda-1	1064..>1155	CDD:212564	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1095..1120
		zf-C2H2	1134..1156	CDD:278523
		C2H2 Zn finger	1136..1156	CDD:275368
		zf-H2C2_2	1148..1173	CDD:290200
		C2H2 Zn finger	1164..1184	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910