DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and SALL2

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_011535366.1	Gene:	SALL2 / 6297	HGNCID:	10526	Length:	1043	Species:	Homo sapiens

Alignment Length:	930	Identity:	203/930 - (21%)
Similarity:	324/930 - (34%)	Gaps:	240/930 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   415 QQRENLASAMAAGMRHHPLLPPPEAMHANPFQLL--RMPLPPALAQAGNVVPTVAPLFGRPSPAD 477
            |:..|.:||.:.        |.||. |.|| |::  ....||   .:|:.||| .|.:|
Human    69 QENPNNSSASSE--------PRPEG-HNNP-QVMDTEHSNPP---DSGSSVPT-DPTWG------ 113

  Fly   478 HYRMEQLVSEQFRHHGFNLAAAAAAAQAQFNANGQVVGGVVSGS----GEPRPPSSSSSGSQRGS 538
               .|:...|...|  |.:||...||     ..|   ||::..|    ..|.||.|:.:...
Human   114 ---PERRGEESSGH--FLVAATGTAA-----GGG---GGLILASPKLGATPLPPESTPAPPP--- 162

  Fly   539 VPPAALPPPSLSSQQQQ-----QQQQAVQQQQQQGAQQQLQSAQQQQQSQQQSQQQQQI------ 592
             ||...|||.:.|....     ::.:.:||:|          ..|.|.::|..:|...:
Human   163 -PPPPPPPPGVGSGHLNIPLILEELRVLQQRQ----------IHQMQMTEQICRQVLLLGSLGQT 216

  Fly   593 -----TPGLVGGAGGSLKLEPQQMDFYS-----QRLRQLAGTTSPGAGSTVNSSSPSPRQ----- 642
                 :|..:.|.|.:...:| .:..:|     |..:.||.::|   .|:.:|.:.:|:|
Human   217 VGAPASPSELPGTGTASSTKP-LLPLFSPIKPVQTSKTLASSSS---SSSSSSGAETPKQAFFHL 277

  Fly   643 -----KQSP---------HFASPSPSQQ---QQQQLATIPRPHSLTPPEKLGDASSE--NGSLGL 688
                 .|.|         |..:|:||..   ...||  |..|| |..|...|..:::  ..:.||
Human   278 YHPLGSQHPFSAGGVGRSHKPTPAPSPALPGSTDQL--IASPH-LAFPSTTGLLAAQCLGAARGL 339

  Fly   689 ILASTPRSASTPPSKTGDVS-------LQEPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYK 746
            ...::| ....|.:.:|::|       |::|... :.|.:|.|.|..::.|.||.|:||||:|||
Human   340 EATASP-GLLKPKNGSGELSYGEVMGPLEKPGGR-HKCRFCAKVFGSDSALQIHLRSHTGERPYK 402

  Fly   747 CTACDFECSHIQKLMKHMRVHRSPADDQDNQDNQDDGSNADSLETNEADNDEDPNPDESEEELGD 811
            |..|....:....|..|...||                        |.......||....|.|
Human   403 CNVCGNRFTTRGNLKVHFHRHR------------------------EKYPHVQMNPHPVPEHL-- 441

  Fly   812 GDNDPDGDGDLDGEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKF 876
             |......|...|.....::.||        |..:....::.|.....||:..||..:..|....
Human   442 -DYVITSSGLPYGMSVPPEKAEE--------EAATPGGGVERKPLVASTTALSATESLTLLSTSA 497

  Fly   877 GLSNIAQYSEAYKQALQESGRKEAAAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRLRDEF 941
            |.:.........|..|.:        |......|.:|...|..|:.:|    |:..::...|.:.
Human   498 GTATAPGLPAFNKFVLMK--------AVEPKNKADENTPPGSEGSAIS----GVAESSTATRMQL 550

  Fly   942 AKNCNMFQQPQDGGAPSQVPLFN--------PFP--------NPFELSKRMKMDGGDWWGMSQAL 990
            :|...        ..||...|.|        |||        :|.|.||.
Human   551 SKLVT--------SLPSWALLTNHFKSTGSFPFPYVLEPLGASPSETSKL--------------- 592

  Fly   991 HRNEALFENLKLKPLGLGGANSLIQG------PLLKKESRQRNDTCEFCGKVFKNCSNLTVHRRS 1049
               :.|.|  |:...|.....|...|      |.....:....:.|..|.:|......|.:|...
Human   593 ---QQLVE--KIDRQGAVAVTSAASGAPTTSAPAPSSSASSGPNQCVICLRVLSCPRALRLHYGQ 652

  Fly  1050 HTGEKPYKCELCSYACAQSSKLTRHMKTH--GRTGKDVYRCRFCDMPFSVPSTLEKHMRK----C 1108
            |.||:|:||::|..|.:....|..|...|  ....:....|..|...|:...||::|:|.    .
Human   653 HGGERPFKCKVCGRAFSTRGNLRAHFVGHKASPAARAQNSCPICQKKFTNAVTLQQHVRMHLGGQ 717

  Fly  1109 VVNQGKA----AAAANAVAAAQAAQAAAQHIQAAAQQAQAVQAQAVQAQAAQQSQQQQQQLSPMG 1169
            :.|.|.|    ..||....:.|:..:.|:.......|..:.:.:..:.:..:..::::.......
Human   718 IPNGGTALPEGGGAAQENGSEQSTVSGARSFPQQQSQQPSPEEELSEEEEEEDEEEEEDVTDEDS 782

  Fly  1170 VVGYPPQFVSGHNLSLPGSVSGDND---------SNASSSMTGVHPISLKEEAXLFSGFPVPLAP 1225
            :.|...:  ||...::  ||.||::         ...:::.|....:...|:. ..|..|   .|
Human   783 LAGRGSE--SGGEKAI--SVRGDSEEASGAEEEVGTVAAAATAGKEMDSNEKTTQQSSLP---PP 840

  Fly  1226 PPPLQQHQPHLQQPQQQQTS 1245
            |||....||   ||.:|.:|
Human   841 PPPDSLDQP---QPMEQGSS 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	8/21 (38%)
		C2H2 Zn finger	719..739	CDD:275368	8/19 (42%)
		zf-H2C2_2	731..756	CDD:338759	13/24 (54%)
		C2H2 Zn finger	747..767	CDD:275368	4/19 (21%)
		zf-C2H2	1029..1050	CDD:333835	5/20 (25%)
		C2H2 Zn finger	1030..1050	CDD:275368	5/19 (26%)
		zf-H2C2_2	1042..1067	CDD:338759	10/24 (42%)
		C2H2 Zn finger	1058..1078	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1088..1106	CDD:275368	6/17 (35%)
SALL2	XP_011535366.1	C2H2 Zn finger	375..395	CDD:275368	8/19 (42%)
		zf-H2C2_2	387..412	CDD:290200	13/24 (54%)
		C2H2 Zn finger	403..423	CDD:275368	4/19 (21%)
		C2H2 Zn finger	633..653	CDD:275368	5/19 (26%)
		zf-H2C2_2	645..670	CDD:290200	10/24 (42%)
		C2H2 Zn finger	661..681	CDD:275368	5/19 (26%)
		zf-C2H2	692..713	CDD:278523	7/20 (35%)
		C2H2 Zn finger	693..713	CDD:275368	7/19 (37%)
		C2H2 Zn finger	913..933	CDD:275370
		C2H2 Zn finger	942..959	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146362
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930