DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9650 and ZNF287

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001333096.1	Gene:	ZNF287 / 57336	HGNCID:	13502	Length:	761	Species:	Homo sapiens

Alignment Length:	533	Identity:	113/533 - (21%)
Similarity:	168/533 - (31%)	Gaps:	190/533 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   638 PSPRQKQSPHFASPSPSQQQ-------------QQQLATIPRPHSLTPPEKLGDASSENGSLGLI 689
            ||..:.||.|....|...::             .|::.|..:|:..   .:.|.|.|:...|.:
Human   381 PSLLKHQSTHAKEKSYECEECGKEFRHISSLIAHQRMHTGEKPYEC---HQCGKAFSQRAHLTI- 441

  Fly   690 LASTPRSASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFEC 754
                     .....||    ::|    |.|..|.|.|....:|.||||||||||||||..|....
Human   442 ---------HQRIHTG----EKP----YKCDDCGKDFSQRAHLTIHQRTHTGEKPYKCLECGKTF 489

  Fly   755 SHIQKLMKHMRVHRSPADDQDNQDNQDDGSNADSLETNEADNDEDPNPDES-------------E 806
            ||...|:.|.|||........|:..:....:...|:..:....:.|.....             .
Human   490 SHSSSLINHQRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRH 554

  Fly   807 EELGDGDNDPDGDGDLDGEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGE 871
            :.:..|                    |:|    ||..:...:..........:||.:|..|.:..
Human   555 QRIHSG--------------------EKC----YKCNECGKAFAHSSTLIQHQTTHTGEKSYICN 595

  Fly   872 LMDK-FGLS-NIAQYSEAYKQALQESGRKEAAAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAA 934
            :..| |..| |:.|:...:      :|.|....:....|
Human   596 ICGKAFSQSANLTQHHRTH------TGEKPYKCSVCGKA-------------------------- 628

  Fly   935 LRLRDEFAKNCNMFQQPQDGGAPSQVPLFNPFPNPFELSKRMKMDGGDWWGMSQALHRNEALFEN 999
                  |:::.::.|.                                     |.:|..|..|:
Human   629 ------FSQSVHLTQH-------------------------------------QRIHNGEKPFK- 649

  Fly  1000 LKLKPLGLGGANSLIQGPLLKKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYA 1064
                                          |..|||.::..:|||.|:|.|||||||||..|..|
Human   650 ------------------------------CNICGKAYRQGANLTQHQRIHTGEKPYKCNECGKA 684

  Fly  1065 CAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEKHMR--------KCVVNQGKAAAAANA 1121
            ...||.|.:|.:||  ||:..|:|..||..||..:.|.:|.|        .|.: .||....:..
Human   685 FIYSSSLNQHQRTH--TGERPYKCNECDKDFSQRTCLIQHQRIHTGEKPYACRI-CGKTFTQSTN 746

  Fly  1122 VAAAQAAQAAAQH 1134
            :...|.....|:|
Human   747 LIQHQRVHTGAKH 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	10/21 (48%)
		C2H2 Zn finger	719..739	CDD:275368	9/19 (47%)
		zf-H2C2_2	731..756	CDD:338759	16/24 (67%)
		C2H2 Zn finger	747..767	CDD:275368	7/19 (37%)
		zf-C2H2	1029..1050	CDD:333835	9/20 (45%)
		C2H2 Zn finger	1030..1050	CDD:275368	9/19 (47%)
		zf-H2C2_2	1042..1067	CDD:338759	16/24 (67%)
		C2H2 Zn finger	1058..1078	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1088..1106	CDD:275368	7/17 (41%)
ZNF287	NP_001333096.1	SCAN	46..144	CDD:413396
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..154
		KRAB	170..227	CDD:214630
		SFP1	<364..419	CDD:227516	7/37 (19%)
		C2H2 Zn finger	370..390	CDD:275368	4/8 (50%)
		C2H2 Zn finger	398..418	CDD:275368	1/19 (5%)
		COG5048	422..755	CDD:227381	103/486 (21%)
		C2H2 Zn finger	426..446	CDD:275368	4/32 (13%)
		C2H2 Zn finger	454..474	CDD:275368	9/19 (47%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		C2H2 Zn finger	510..530	CDD:275368	2/19 (11%)
		C2H2 Zn finger	538..558	CDD:275368	0/19 (0%)
		C2H2 Zn finger	566..586	CDD:275368	1/19 (5%)
		C2H2 Zn finger	594..614	CDD:275368	5/19 (26%)
		C2H2 Zn finger	622..642	CDD:275368	4/88 (5%)
		C2H2 Zn finger	650..670	CDD:275368	9/19 (47%)
		C2H2 Zn finger	678..698	CDD:275368	7/19 (37%)
		C2H2 Zn finger	706..726	CDD:275368	8/19 (42%)
		C2H2 Zn finger	734..754	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000