DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and znf296

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001037784.1	Gene:	znf296 / 553232	ZFINID:	ZDB-GENE-050419-201	Length:	636	Species:	Danio rerio

Alignment Length:	1227	Identity:	243/1227 - (19%)
Similarity:	346/1227 - (28%)	Gaps:	637/1227 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LSISEDHGFRSLSHSDSTENDAVATQ----DILTCGACQKAFALSDIVKFIQHKVLQCNKENYGQ 66
            ||:.:|....:|..|.|:.......:    |:||||.|.:||.|:.|:.|||||        .|.
Zfish    13 LSVMQDDPNSTLITSSSSSEQIPEPEDEGRDLLTCGQCGQAFPLAHILNFIQHK--------QGG 69

  Fly    67 CATQNPQMDRDAEEGRPLSLVNRRPSISAPISGRKSAPASAAAAVAAAAAAAAAAAAASSTASGS 131
            |.|         ...||..
Zfish    70 CGT---------ARARPQG---------------------------------------------- 79

  Fly   132 RIHTPPPSPADLLADGASSTPKRLVDENDNTTPKDSETGATTLDSNAAPSSPAAIERQSSGDSSC 196
              || |||||           .|.|..:..|   ..|.|..
Zfish    80 --HT-PPSPA-----------SRTVQCSQGT---KVEAGYV------------------------ 103

  Fly   197 EMEEQQDRQDKQSQPKQAKVKQEPYDEEGVNHHQNQDDDDDEEMEERSLAKRPKMELVDAEANTV 261
            |:....||          :.|:||    ||.                            .|||..
Zfish   104 ELRRVTDR----------RWKEEP----GVR----------------------------VEANRA 126

  Fly   262 HTEPSNYTCSTCKTRYTSAWRLIQHVQHSHGVKIYVESPGGGATLTVATPAALNNSALALAAAAA 326
            . |||.:||..|:..::|||.|:||.|.:|.:.||.|..         ||.
Zfish   127 E-EPSVFTCQVCQCVFSSAWNLLQHAQITHSLNIYQEDD---------TPT-------------- 167

  Fly   327 AASASGLASPQPAVSPNPAVTSSAKRSSPLGAAGSTILSTSVSSTCSNSLVNTSGGSISNTSSIG 391
                   .:.:||...:|         ..||||.:|..
Zfish   168 -------QTSKPAAMMDP---------RHLGAALATAF--------------------------- 189

  Fly   392 SPQQQQLQLQQQQAQQQQQRVQQQQRENLASAMAAGMRHHPLLPPPEAMHANPFQLLRMPLPPAL 456
                                    |..:|.||       .|..|||.:.|.
Zfish   190 ------------------------QPSSLRSA-------RPHKPPPSSTHV-------------- 209

  Fly   457 AQAGNVVPTVAPLFGRPSPADHYRMEQLVSEQFRHHGFNLAAAAAAAQAQFNANGQVVGGVVSGS 521
                              |.|             ..|.|
Zfish   210 ------------------PRD-------------LQGLN-------------------------- 217

  Fly   522 GEPRPPSSSSSGSQRGSVPPAALPPPSLSSQQQQQQQQAVQQQQQQGAQQQLQSAQQQQQSQQQS 586

Zfish   218 ----------------------------------------------------------------- 217

  Fly   587 QQQQQITPGLVGGAGGSLKLEPQQMDFYSQRLRQLAGTTSPGAGSTVNSSSPSPRQKQSPHFASP 651
                                       :|..|::|| ..|..:|..|.|.||||          |
Zfish   218 ---------------------------FSMCLQRLA-EVSCSSGGVVPSPSPSP----------P 244

  Fly   652 SPSQQQQQQLATIPRPHSLTPPEKLGDASSENGSLGLILASTPRSASTPPSKTGDVSLQEPIAHC 716
            :.|          |.||                             |||...|           .
Zfish   245 AAS----------PFPH-----------------------------STPSIHT-----------A 259

  Fly   717 YSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPADDQDNQDNQD 781
            :||..|.:.|:...:|..|:|||..::||.|..|....|...:|.:|||.||..|..|:.
Zfish   260 FSCEMCGQGFQSLRSLSAHRRTHACDRPYHCGLCQLTFSQSGELARHMRSHRRSAAGQET----- 319

  Fly   782 DGSNADSLETNEADNDEDPNP---DESEEELGDGDNDPDG--DGDLDGEDEDEDELEECEDMDYK 841
                            .||:|   ||..:..|.||||..|  .|.|:.
Zfish   320 ----------------SDPSPASADEDRKLSGPGDNDISGGHGGSLEA----------------- 351

  Fly   842 AEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQALQESGR---KEAAAA 903
                       ||.      ..||:.::..|..:....|:.:|   |::.::|..:   ::.:..
Zfish   352 -----------GKH------PGGASLILMPLQTRAADRNLLRY---YQREVEEEVQGEPQQPSPY 396

  Fly   904 AAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNPFPN 968
            .:.:..:.::.:.||:|.      :|:.          :.||.. ::|:....|.
Zfish   397 GSPSEGSLESGDTGGSGE------SGIA----------SGNCTP-KRPEREDRPQ---------- 434

  Fly   969 PFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKKESRQ-------- 1025
                        |||....:|:                     .::|....:.|.||
Zfish   435 ------------GDWEQEVEAV---------------------EIVQDWQRENERRQVTNGMGKK 466

  Fly  1026 -RNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTG-KDVYRC 1088
             :.:.||||||.|:|.|||||||||||||:||:|.||||||||||||||||||||..| :..::|
Zfish   467 KKEEACEFCGKCFRNSSNLTVHRRSHTGERPYRCGLCSYACAQSSKLTRHMKTHGARGTRAPFQC 531

  Fly  1089 RFCDMPFSVPSTLEKHMRKCVVNQGKAAAAANAVAAAQAAQAAAQHIQAAAQQAQAVQAQAVQAQ 1153
            :.|.:||:|.:|||||::|.   .|...|:....:.:...:..:..|: ...::.:.|:.|....
Zfish   532 QLCSVPFTVYATLEKHLKKV---HGLTHASVGTYSQSSLTEYNSLGIK-LEDESISDQSGAPITM 592

  Fly  1154 AAQQSQQQQQQLSPMGVVGYPPQFVSGHNLSLPGSVSGDNDSNASSSMTGVHPISLK 1210
            .|..|..|.:||.                         :.|:....|.|...|||.|
Zfish   593 LADSSVDQTEQLK-------------------------EEDTEMRVSSTDEPPISEK 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	7/21 (33%)
		C2H2 Zn finger	719..739	CDD:275368	6/19 (32%)
		zf-H2C2_2	731..756	CDD:338759	9/24 (38%)
		C2H2 Zn finger	747..767	CDD:275368	7/19 (37%)
		zf-C2H2	1029..1050	CDD:333835	16/20 (80%)
		C2H2 Zn finger	1030..1050	CDD:275368	16/19 (84%)
		zf-H2C2_2	1042..1067	CDD:338759	21/24 (88%)
		C2H2 Zn finger	1058..1078	CDD:275368	18/19 (95%)
		C2H2 Zn finger	1088..1106	CDD:275368	10/17 (59%)
znf296	NP_001037784.1	C2H2 Zn finger	262..282	CDD:275368	6/19 (32%)
		zf-C2H2	288..310	CDD:278523	8/21 (38%)
		C2H2 Zn finger	290..310	CDD:275368	7/19 (37%)
		C2H2 Zn finger	472..492	CDD:275368	16/19 (84%)
		zf-C2H2	472..492	CDD:278523	16/19 (84%)
		zf-H2C2_2	484..509	CDD:290200	21/24 (88%)
		C2H2 Zn finger	500..520	CDD:275368	18/19 (95%)
		C2H2 Zn finger	531..549	CDD:275368	10/17 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D121311at33208
OrthoFinder	1	1.000	-	-		FOG0002010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45993
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	5.070