DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and ZNF219

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_005267796.1	Gene:	ZNF219 / 51222	HGNCID:	13011	Length:	768	Species:	Homo sapiens

Alignment Length:	840	Identity:	167/840 - (19%)
Similarity:	242/840 - (28%)	Gaps:	321/840 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 ATLTVATPAALNNSALALAAAAAAASASGLASPQPAVSPNPAVTSSAKRSSPLGAAGSTILSTSV 368
            :|..||..::.::|:|............|..|||   ...|...|.....||....|..
Human    15 STAPVAFISSFSSSSLHFPEPKNVKGVHGDLSPQ---GSRPRAPSGHLAPSPPAFDGEL------ 70

  Fly   369 SSTCSNSLVNTSGGSISNTSSIGSPQQQQLQLQQQQAQQQQQRVQQQ---QRENLASAMAAGMRH 430
                  .|...|.|...:..|:|..     .:...:::..::|....   :|....|.:|..:|.
Human    71 ------DLQRYSNGPAVSAGSLGMG-----AVSWSESRAGERRFPCPVCGKRFRFNSILALHLRA 124

  Fly   431 HP---LLPPPEAMH-ANPFQLLRMPLPPALAQAGNVVPTVAPLFGRP-SPADHYRMEQLVSEQFR 490
            ||   ....|...| |....|||..|           .|..|  .|| |||....:|.......|
Human   125 HPGAQAFQCPHCGHRAAQRALLRSHL-----------RTHQP--ERPRSPAARLLLELEERALLR 176

  Fly   491 HHGFNLAAAAAAAQAQFNANGQVVGGVVSGSGEPRPPSSSS------SGSQRGSVPPAALPPPSL 549
            ......|.::...||.         ....|...|:.||||:      .|..|
Human   177 EARLGRARSSGGMQAT---------PATEGLARPQAPSSSAFRCPYCKGKFR------------- 219

  Fly   550 SSQQQQQQQQAVQQQQQQGAQQQLQSAQQQQQSQQQSQQQQQITPGLVGGAGGSLKLEPQQMDFY 614
            :|.::::....:.:..:.|.           .|...||:::.:...|.  |.|:    |:
Human   220 TSAERERHLHILHRPWKCGL-----------CSFGSSQEEELLHHSLT--AHGA----PE----- 262

  Fly   615 SQRLRQLAGTTSPGAGSTVNSSSPSPRQKQSPHFASPSPSQQQQQQLATIPRPHSLTPPEKLGDA 679
                |.||.|          |::|.|:         |.|....|.:..::|:|.....||:
Human   263 ----RPLAAT----------SAAPPPQ---------PQPQPPPQPEPRSVPQPEPEPEPER---- 300

  Fly   680 SSENGSLGLILASTPRSASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKP 744
                       .:||..|...|.       :.|....:.|..|.:.|.....|..|.|.|.....
Human   301 -----------EATPTPAPAAPE-------EPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFD 347

  Fly   745 YKCTACDFECSHIQKLMKHMRVHRS---------PADDQDNQDNQDD-GSNA-----DSLETNEA 794
            :.|..|.........|..||:||.|         ||..........| |..|     .:|....|
Human   348 HACPVCGRCFKEPWFLKNHMKVHASKLGPLRAPGPASGPARAPQPPDLGLLAYEPLGPALLLAPA 412

  Fly   795 DNDEDPNPDESEE--------ELGDGDNDPDGDGDLDG-------------------------ED 826
                 |.|.|..|        .|..|:..|:|:|...|                         |.
Human   413 -----PTPAERREPPSLLGYLSLRAGEGRPNGEGAEPGPGRSFGGFRPLSSALPARARRHRAEEP 472

  Fly   827 EDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQA 891
            |:|:|:.|.|:                     :|.:.|.:  :|.|            :..:.:.
Human   473 EEEEEVVEAEE---------------------ETWARGRS--LGSL------------ASLHPRP 502

  Fly   892 LQESGRKEAAAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDG-G 955
            .:..|...:||.|.|.:.|....             |||.|...|              |:.| |
Human   503 GEGPGHSASAAGAQARSTATQEE-------------NGLLVGGTR--------------PEGGRG 540

  Fly   956 APSQVPLFNPFPNPFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLK 1020
            |                      .|.|
Human   541 A----------------------TGKD-------------------------------------- 545

  Fly  1021 KESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGR 1080
                     |.||||.|::..:|.||.|.||||:||||..|.||..||..|..|::.|.|
Human   546 ---------CPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHR 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	6/21 (29%)
		C2H2 Zn finger	719..739	CDD:275368	6/19 (32%)
		zf-H2C2_2	731..756	CDD:338759	6/24 (25%)
		C2H2 Zn finger	747..767	CDD:275368	5/19 (26%)
		zf-C2H2	1029..1050	CDD:333835	10/20 (50%)
		C2H2 Zn finger	1030..1050	CDD:275368	10/19 (53%)
		zf-H2C2_2	1042..1067	CDD:338759	15/24 (63%)
		C2H2 Zn finger	1058..1078	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1088..1106	CDD:275368
ZNF219	XP_005267796.1	C2H2 Zn finger	105..125	CDD:275368	4/19 (21%)
		C2H2 Zn finger	133..153	CDD:275368	7/30 (23%)
		C2H2 Zn finger	211..229	CDD:275368	3/30 (10%)
		C2H2 Zn finger	237..253	CDD:275368	4/26 (15%)
		zf-C2H2	320..342	CDD:278523	6/21 (29%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		ARS2	<350..454	CDD:282772	25/108 (23%)
		C2H2 Zn finger	350..370	CDD:275368	5/19 (26%)
		C2H2 Zn finger	546..566	CDD:275368	10/19 (53%)
		zf-C2H2	546..566	CDD:278523	10/19 (53%)
		zf-H2C2_2	558..580	CDD:290200	13/21 (62%)
		C2H2 Zn finger	574..594	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930