DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9650 and Zfp948

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001002008.1	Gene:	Zfp948 / 381066	MGIID:	3040683	Length:	667	Species:	Mus musculus

Alignment Length:	619	Identity:	134/619 - (21%)
Similarity:	205/619 - (33%)	Gaps:	179/619 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   548 SLSSQQQQQQQQAVQQQQQQ------GAQQQLQS---AQQQQQSQQQSQQQQQITPGLVGGAGGS 603
            |.|..|.|:...|.::|:|:      .:...|:|   ||.|:.:....:|.|:    ..||...|
Mouse   138 SSSIAQDQRTNSANKEQRQEKHGGHFSSTHSLKSSSIAQDQRTNSANKEQGQE----KHGGHFSS 198

  Fly   604 LKLEPQQMDFYSQRLRQLAGTT---SPGAGSTVNSSSPSPRQKQSPHFASPSPSQ----QQQQQL 661
            .....||..|..::..|.....   |..|..|::....:..:....:|...|.:|    :..|:|
Mouse   199 THSLMQQAIFNREKRYQCGQCQRCFSTSANLTIHQRIHTGEKPYKCNFCDKSFAQCTTLKTHQRL 263

  Fly   662 ATIPRPHSLTPPEKLGDASSENGSLGLILASTPRSASTPPSKTGDVSLQEPIAHCYSCSYCDKKF 726
            .|..:|                                                 |.|..|.|.|
Mouse   264 HTGEKP-------------------------------------------------YKCKECGKSF 279

  Fly   727 RFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPADDQDNQDNQDDGSNADSLET 791
            ...:.|..||:.|||||||||..||...:|.....:|.:.||:     ......|.|.:...|..
Mouse   280 PQLSALKSHQKMHTGEKPYKCKECDRFFAHCSSFRRHQKTHRA-----KKHTGPDCGKDLHQLSH 339

  Fly   792 NEADNDEDPNPDESEEELGDGDNDPDGDGDLDGEDEDEDELEECE------------------DM 838
            .::|:           .|..|:|              ..:..||:                  ::
Mouse   340 FKSDH-----------RLHTGEN--------------PYKCSECDRSFPHYELFRIHQKTHSSEI 379

  Fly   839 DYKAEDLSVSNRIDGKS-------QSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQALQESG 896
            ||:.|:.       |||       :......||||.......||    :..|||...|.....:|
Mouse   380 DYECEEC-------GKSFTELLQLRRHYKIHSGATLYKCRDCDK----SFTQYSHLQKHQTIHTG 433

  Fly   897 RKEAAAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVP 961
            .:.........:...::..|........:|    |.........|.:| ::.:|.|.
Mouse   434 ERPYKCKDCEKSFLHNSLLRRHQSVHTGEK----PYKCKECDKSFTRN-SILRQHQK-------- 485

  Fly   962 LFNPFPNPFELSKRMKMDGG----DWWGMSQALHRNEALFENLKLKPLGLGGAN-SLIQGPLLKK 1021
             .:....|:   |.::.|..    .:....|.:|..|        ||......: |...|..|:.
Mouse   486 -IHTKEKPY---KCVECDKSFTQLTYLRTHQRVHTKE--------KPYNCTVCDKSFTTGATLRI 538

  Fly  1022 ESR----QRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTG 1082
            ..|    :|...|..|||.|:..:.|..|::.|||||||.|.:|..:..:.|.|.||.:.|  ||
Mouse   539 HQRVHTGERPYRCTECGKSFREGTTLRTHKKIHTGEKPYNCTVCDKSFIRYSHLQRHQRVH--TG 601

  Fly  1083 KDVYRCRFCDMPFSVPSTLEKHMR--------KC 1108
            :..|:|..||..|:....|.||.|        ||
Mouse   602 EKPYKCMECDKSFTECFLLRKHQRIHTEEKPYKC 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	8/21 (38%)
		C2H2 Zn finger	719..739	CDD:275368	7/19 (37%)
		zf-H2C2_2	731..756	CDD:338759	14/24 (58%)
		C2H2 Zn finger	747..767	CDD:275368	5/19 (26%)
		zf-C2H2	1029..1050	CDD:333835	7/20 (35%)
		C2H2 Zn finger	1030..1050	CDD:275368	7/19 (37%)
		zf-H2C2_2	1042..1067	CDD:338759	11/24 (46%)
		C2H2 Zn finger	1058..1078	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1088..1106	CDD:275368	7/17 (41%)
Zfp948	NP_001002008.1	KRAB	12..52	CDD:396083
		COG5048	195..595	CDD:227381	102/514 (20%)
		C2H2 Zn finger	216..236	CDD:275368	3/19 (16%)
		C2H2 Zn finger	244..264	CDD:275368	4/19 (21%)
		C2H2 Zn finger	272..292	CDD:275368	7/19 (37%)
		C2H2 Zn finger	300..320	CDD:275368	5/19 (26%)
		C2H2 Zn finger	328..346	CDD:275368	4/28 (14%)
		C2H2 Zn finger	355..375	CDD:275368	2/19 (11%)
		C2H2 Zn finger	383..403	CDD:275368	4/26 (15%)
		C2H2 Zn finger	411..431	CDD:275368	6/23 (26%)
		C2H2 Zn finger	439..459	CDD:275368	1/19 (5%)
		C2H2 Zn finger	467..487	CDD:275368	4/29 (14%)
		C2H2 Zn finger	495..515	CDD:275368	2/19 (11%)
		C2H2 Zn finger	523..543	CDD:275368	4/19 (21%)
		C2H2 Zn finger	551..571	CDD:275368	7/19 (37%)
		C2H2 Zn finger	579..599	CDD:275368	6/19 (32%)
		zf-H2C2_2	591..615	CDD:404364	10/25 (40%)
		C2H2 Zn finger	607..627	CDD:275368	8/19 (42%)
		C2H2 Zn finger	635..655	CDD:275368	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910