DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and salm

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster

Alignment Length:	1461	Identity:	282/1461 - (19%)
Similarity:	452/1461 - (30%)	Gaps:	557/1461 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SISEDHGFRSLSHSDSTENDAVATQDILTCGACQKAFALSDIVKFIQHKVLQCNKENYGQCATQN 71
            |..:|.|      ||..||...:.   ||......:.:.|...:..|.:....::::..:.:|.:
  Fly    47 SADKDIG------SDQEENGGCSP---LTTATTTASPSRSPEPEEEQPEEQSTSEQSIPEQSTPD 102

  Fly    72 PQMDRDAE-----EGRPLSLVNRRPSISAPISGRKSAPASAAAAVAAAAAAAAAAAAASSTASGS 131
            .|::.|.:     |..|:...|.|.:::.|.|..:...||.:...:..|.|:|..||...|....
  Fly   103 HQLENDIKSEAKSEIEPVEDNNNRVAMTKPSSEEREPNASGSMPSSPVAEASAEEAATERTPEKE 167

  Fly   132 R-------IHTPPPSPA------DLLADGASSTPKRLVDENDNT-------TPKDSETGATTLDS 176
            :       :..|..:|:      ::...|.:..|..| :...|.       ..|....|:...|:
  Fly   168 KEKDVEVDVEKPDEAPSSAVPSTEVTLPGGAGAPVTL-EAIQNMQMAIAQFAAKTIANGSNGADN 231

  Fly   177 NAAPSSPAAIERQSSGDSSCEMEEQQDRQDKQSQPKQAKVKQEPYDEEGVNHHQNQDDDDDEEME 241
            .||....|.:::........::.:.|..|..|||....:.|||...||..:..|:|:.:.|...|
  Fly   232 EAAMKQLAFLQQTLFNLQQQQLFQIQLIQQLQSQLALNQAKQEEDTEEDADQEQDQEQETDTYEE 296

  Fly   242 ERSLAK---RPKMELVDAEANTVHTEPSNYTCSTCKTRYTSAWRLIQHVQHSHGVKIYVESPGGG 303
            |..:|.   |.|.|...|||               |.|        ||:.:: ||.:. ||.|
  Fly   297 EERIADMELRQKAEARMAEA---------------KAR--------QHLINA-GVPLR-ESSG-- 334

  Fly   304 ATLTVATPA-------------------ALNNSALALAAAAAAAS-----------ASGLAS--- 335
                  :||                   :|:|:..|..|..|.|.           .|.|||
  Fly   335 ------SPAESLKRRREHDHESQPNRRPSLDNTHKADTAQDALAKLKEMENTPLPFGSDLASSII 393

  Fly   336 ------PQPAVSPNPAVTSSAKRSSPLGAAGSTILSTSVSSTCSNSLVNTSG------------- 381
                  |:    ||.......:....|.:|...||:.|::...:....:..|
  Fly   394 TNHDDLPE----PNSLDLLQKRAQEVLDSASQGILANSMADDFAFGEKSGEGKGRNEPFFKHRCR 454

  Fly   382 --GSISNTSSIGSPQQQQLQLQQQQAQQQ--------------QQRVQQQQRENLASAMAAGMRH 430
              |.:     .||....|:.::....::.              ..:|..|:.       |....|
  Fly   455 YCGKV-----FGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRH-------AQKFPH 507

  Fly   431 HPLLPPPEAMHANPFQ--LL-----------RMPLPPALAQAGNVVPTVAPLFGRPSPADHYR-- 480
            .|:...|...|.:.|.  ||           ..|.||.|..|....|   |.|  |...:.||
  Fly   508 VPMNATPIPEHMDKFHPPLLDQMSPTDSSPNHSPAPPPLGSAPASFP---PAF--PGLQNLYRPP 567

  Fly   481 MEQLVSEQFRHHGFNLAAAAAAAQAQFNANGQVVGGVVSGSGEPRPPSSSSSGSQRGSVPPAALP 545
            ||.|.|           ..|||....|                   |....:..::        |
  Fly   568 MEILKS-----------LGAAAPHQYF-------------------PQELPTDLRK--------P 594

  Fly   546 PPSLSSQQQQQQQQAVQQQQQQGAQQQ----------------LQSAQQQQQSQQQSQQQ----- 589
            .|.|...:.|.:.:.|:::.|:...:|                ::..:::.:.|:|.:|:
  Fly   595 SPQLDEDEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQEDHRIE 659

  Fly   590 ----------------------------QQITPGLV----GGAGGSLKLE--------PQQMDFY 614
                                        |.|.|..:    ...|....|:        |.:.||:
  Fly   660 PRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSHLDHLPTPGQLPPREDFF 724

  Fly   615 SQRLRQLAGTT-------------SPGAGSTVNSSSPSPRQKQSPHFASPSP--SQQQQQQLATI 664
            ::|. .|..||             ||..|:......|.|.  ..||..:.||  :..:.:..|.:
  Fly   725 AERF-PLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPH--HHPHHMARSPFFNPIKHEMAALL 786

  Fly   665 PRPHSLTPPEKLGDASSENGSLGLILASTPRSASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFE 729
            |||||       .|.|.||      ......:..|  .|..::...:.|:....|..||:....:
  Fly   787 PRPHS-------NDNSWEN------FIEVSNTCET--MKLKELMKNKKISDPNQCVVCDRVLSCK 836

  Fly   730 NNLIIHQRTHTGEKPYKCTACD-------------------------FEC-------SHIQKLMK 762
            :.|.:|.||||||:|:||..|.                         .:|       |:...|.:
  Fly   837 SALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQ 901

  Fly   763 HMRVHRSPADDQDNQDNQ----------------------------------------DDGSNAD 787
            |:|:|.....|...:..|                                        :.|::..
  Fly   902 HIRLHTGEPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNHGAHNG 966

  Fly   788 SL--ETNEADND------EDPNPDESEEELGDGDNDPDGDGDLDGEDEDEDELEECEDMDY---- 840
            :|  |:::.|.|      ||.:.|.|.|.|.:.:.:.:||....|:|......|:...:|.
  Fly   967 ALGSESSQGDMDDNMDCGEDYDDDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVV 1031

  Fly   841 ------------------------KAEDLSVSNRIDGKSQSP-----------------KTTSSG 864
                                    .:..:..|:::..:|.||                 .|:||.
  Fly  1032 NTNPVRPRSSASSHGHSVGSTSAPTSPSVHASSQVIKRSSSPARSEASQGALDLTPRAAPTSSSS 1096

  Fly   865 ATS---------------------------LVGELMDKFG------------------------- 877
            :.|                           |...|....|
  Fly  1097 SRSPLPKEKPVSPPSLPRSPSGSSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAA 1161

  Fly   878 --------------LSNIAQYSEAYKQALQESGRKEAAAAAAAAAAAA----------DNNNRGG 918
                          ::.:.|:.|..::...|:.:|.||||||||||||          |....||
  Fly  1162 VAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGG 1226

  Fly   919 AGAPLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNPFPNPFELSKRMKMDGGDW 983
            .||       |.|           .|..|..:|..|..|: :|||.|....
  Fly  1227 PGA-------GPP-----------PNPLMGARPPFGMFPN-LPLFPPATTQ-------------- 1258

  Fly   984 WGMSQALHR-NEALFENLKLKPLGLGGANSLIQGPLLKKESRQRNDTCEFCGKVFKNCSNLTVHR 1047
             .|..|::: .:::.......||.|.|    ::|          :.||..|.|.|...|.|.:|.
  Fly  1259 -NMCNAMNQIAQSVMPAAPFNPLALSG----VRG----------STTCGICYKTFPCHSALEIHY 1308

  Fly  1048 RSHTGEKPYKCELCSYACAQSSKLTRHMKTH 1078
            ||||.|:|:||.:|.........|.:||.||
  Fly  1309 RSHTKERPFKCSICDRGFTTKGNLKQHMLTH 1339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	6/21 (29%)
		C2H2 Zn finger	719..739	CDD:275368	6/19 (32%)
		zf-H2C2_2	731..756	CDD:338759	13/56 (23%)
		C2H2 Zn finger	747..767	CDD:275368	7/51 (14%)
		zf-C2H2	1029..1050	CDD:333835	9/20 (45%)
		C2H2 Zn finger	1030..1050	CDD:275368	8/19 (42%)
		zf-H2C2_2	1042..1067	CDD:338759	11/24 (46%)
		C2H2 Zn finger	1058..1078	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1088..1106	CDD:275368
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	4/26 (15%)
		C2H2 Zn finger	453..473	CDD:275368	4/24 (17%)
		zf-H2C2_2	465..490	CDD:290200	1/24 (4%)
		C2H2 Zn finger	481..501	CDD:275368	2/19 (11%)
		C2H2 Zn finger	826..846	CDD:275368	6/19 (32%)
		zf-H2C2_2	838..863	CDD:290200	12/24 (50%)
		zf-C2H2_2	854..922	CDD:289522	10/67 (15%)
		C2H2 Zn finger	854..874	CDD:275368	2/19 (11%)
		C2H2 Zn finger	886..906	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1291..1311	CDD:275368	8/19 (42%)
		zf-H2C2_2	1303..1328	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1319..1339	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447776
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930