DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9650 and ZNF678

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_848644.2	Gene:	ZNF678 / 339500	HGNCID:	28652	Length:	580	Species:	Homo sapiens

Alignment Length:	403	Identity:	100/403 - (24%)
Similarity:	132/403 - (32%)	Gaps:	159/403 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 YSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACD---FECSHIQKLMKHMRVHRSPADDQDNQD 778
            |.|..|.|.|...:||..|:|.|||||||||..|.   .||||   |.:|.|:|......:..:.
Human   292 YKCKECCKAFNKFSNLTQHKRIHTGEKPYKCEECGNVFNECSH---LTRHRRIHTGEKPYKCEEC 353

  Fly   779 NQDDGSNADSLETNEADNDEDPNPDESEEELGDGDNDPDGDGDLDGEDEDEDELEECEDMDYKAE 843
            .:.....|...........|.|.                             :.|||.....:..
Human   354 GKAFTQFASLTRHKRIHTGEKPY-----------------------------QCEECGKTFNRCS 389

  Fly   844 DLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQALQESGRKEAAAAAAAAA 908
            .||...||....:..|....|.|      ..:|  ||:.|:...:      :|.|
Human   390 HLSSHKRIHTGEKPYKCEECGRT------FTQF--SNLTQHKRIH------TGEK---------- 430

  Fly   909 AAADNNNRGGAGAPLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNPFPNPFELS 973
                         |..                 .|.|        |.|      ||.|.:   |:
Human   431 -------------PYK-----------------CKEC--------GKA------FNKFSS---LT 448

  Fly   974 KRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKKESRQRNDTCEFCGKVFK 1038
            :..::..|                    :||.                       .||.||||||
Human   449 QHRRIHTG--------------------VKPY-----------------------KCEECGKVFK 470

  Fly  1039 NCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEK 1103
            .||:||.|:|.|||||||||:.|..|..|||.|::|.:.|  |.:..|:|..|...|:..|:|.:
Human   471 QCSHLTSHKRIHTGEKPYKCKECGKAFYQSSILSKHKRIH--TEEKPYKCEECGKAFNQFSSLTR 533

  Fly  1104 HMR--------KC 1108
            |.|        ||
Human   534 HKRIHTGEKRYKC 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	9/21 (43%)
		C2H2 Zn finger	719..739	CDD:275368	8/19 (42%)
		zf-H2C2_2	731..756	CDD:338759	16/27 (59%)
		C2H2 Zn finger	747..767	CDD:275368	9/22 (41%)
		zf-C2H2	1029..1050	CDD:333835	14/20 (70%)
		C2H2 Zn finger	1030..1050	CDD:275368	14/19 (74%)
		zf-H2C2_2	1042..1067	CDD:338759	15/24 (63%)
		C2H2 Zn finger	1058..1078	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1088..1106	CDD:275368	6/17 (35%)
ZNF678	NP_848644.2	KRAB	44..101	CDD:214630
		KRAB	44..83	CDD:279668
		COG5048	138..536	CDD:227381	97/391 (25%)
		C2H2 Zn finger	154..174	CDD:275368
		zf-H2C2_2	167..191	CDD:290200
		C2H2 Zn finger	182..202	CDD:275368
		zf-H2C2_2	194..218	CDD:290200
		C2H2 Zn finger	210..230	CDD:275368
		zf-H2C2_2	223..246	CDD:290200
		C2H2 Zn finger	238..258	CDD:275368
		zf-H2C2_2	251..275	CDD:290200
		C2H2 Zn finger	266..286	CDD:275368
		zf-H2C2_2	278..302	CDD:290200	4/9 (44%)
		C2H2 Zn finger	294..314	CDD:275368	8/19 (42%)
		zf-H2C2_2	306..330	CDD:290200	14/23 (61%)
		C2H2 Zn finger	322..342	CDD:275368	9/22 (41%)
		zf-H2C2_2	334..359	CDD:290200	5/27 (19%)
		C2H2 Zn finger	350..370	CDD:275368	1/19 (5%)
		zf-H2C2_2	362..387	CDD:290200	5/53 (9%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		zf-H2C2_2	390..415	CDD:290200	7/30 (23%)
		C2H2 Zn finger	406..426	CDD:275368	6/27 (22%)
		zf-H2C2_2	418..442	CDD:290200	9/83 (11%)
		C2H2 Zn finger	434..454	CDD:275368	8/36 (22%)
		zf-H2C2_2	446..471	CDD:290200	11/70 (16%)
		C2H2 Zn finger	462..482	CDD:275368	14/19 (74%)
		zf-H2C2_2	474..497	CDD:290200	14/22 (64%)
		C2H2 Zn finger	490..510	CDD:275368	8/19 (42%)
		zf-H2C2_2	503..527	CDD:290200	8/25 (32%)
		C2H2 Zn finger	518..538	CDD:275368	7/19 (37%)
		zf-H2C2_2	530..553	CDD:290200	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000