DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and peb

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001014722.1	Gene:	peb / 31391	FlyBaseID:	FBgn0003053	Length:	1894	Species:	Drosophila melanogaster

Alignment Length:	1509	Identity:	293/1509 - (19%)
Similarity:	477/1509 - (31%)	Gaps:	541/1509 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SHSDSTENDAVATQDILTCGACQKAFALSDIVKFIQHKVLQCNKENYGQCATQNPQMDRDAEEGR 82
            :.::|.|:||..:.|:.:..:..::.:..:......||. ..|.::..:........|.:.::.|
  Fly   387 ARAESYESDASCSTDVSSGHSHSRSSSSLNNNNNNSHKA-NNNLKDLEELEVSTEDQDTENKQRR 450

  Fly    83 PLSLVNRR--PSISAPISGRKSAPASAAAAVAAAAAAAAAAAAASSTASGSRIHTPPP--SPADL 143
            ..:.:|..  .|........:.|..:..|.:.:....|...|.||::.:.||..||.|  |||.|
  Fly   451 LKTTINNNIIESEQQEDMDDEEADDADVAMLTSTPDVATLLAGASASGAASRSPTPSPSASPALL 515

  Fly   144 L---ADGAS---STPKRLV--DENDNTTP---KDSETGATT----------------------LD 175
            |   |.|||   :.|...|  |...:..|   :|.|....|                      |.
  Fly   516 LSCPACGASDFETLPALCVHLDAMHSDIPAKCRDCEVIFATHRQLQSHCCRLPNALAGGLPPLLG 580

  Fly   176 SNAAPSSPAAIERQSSGDSSCEMEEQQDRQDKQSQP---------KQAK-----------VKQEP 220
            ::::|......|.:..||.  |..||::|...||:.         |.|.           :|.||
  Fly   581 ASSSPLHNEEPEDEEHGDD--EDLEQKERLASQSEDFFHQLYLKHKTANGCGAISHPPSPIKHEP 643

  Fly   221 YD------------------------EEGVN-----HHQNQDDDDDEEMEERSLAKRPKMEL--- 253
            .|                        |:.||     .:.....|.:||.::...::..:|:|
  Fly   644 ADTKDLADIQSILNMTSSSSSFLRNFEQSVNTPNSSQYSLDGRDQEEEAQDAFTSEFRRMKLRGE 708

  Fly   254 ------------------------------------------VDAEANTVHTEPSN----YTCST 272
                                                      .|..|...|....|    |.|:.
  Fly   709 FPCKLCTAVFPNLRALKGHNRVHLGAVGPAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAV 773

  Fly   273 CKTRYTSAWRLIQHVQHSHGVKIYVESPGGGATLTVATPAALNNSALALAAAAAAASASGLASPQ 337
            |...:|:.....:|:::.|| |...|..........|..|...:|...|....|..|...: ||.
  Fly   774 CNYAFTTKANCERHLRNRHG-KTSREEVKRAIVYHPAEDAGCEDSKSRLGEDLADTSFRSI-SPT 836

  Fly   338 PAVSPNPAVTSS-----------------------------------AKRSSPL----------- 356
            |   |.|.|..|                                   .|.|:|.
  Fly   837 P---PPPPVNESKSQLKHMLLGENHLAPVNQQPPLKIQVKSLDQLVDKKPSAPAPQQQQQQQQQE 898

  Fly   357 --GAA---------------GSTILSTSVSSTCSNSLVN--TSGGSISNTSSIGSP------QQQ 396
              |:|               |...|:.:|:.|.:.:.|.  |.||       :|:|      :||
  Fly   899 KSGSALDFSMDVLDLSKKPTGGASLTPAVTRTPTPAAVAPVTPGG-------VGTPDLAAAIEQQ 956

  Fly   397 QLQLQQQQA-QQQQQRVQQQQRENLASAMAAGMRHHPLL--PPPEA-----------MHANPFQL 447
            ||.|.|||. ....:.:||..|..:..:..:|....|.:  |||:|           ...||..:
  Fly   957 QLLLAQQQLFGAGGEYMQQLFRSLMFQSQTSGFPFFPFMAPPPPQANPEKPPMVSPPNRINPMPV 1021

  Fly   448 ---LRMPLPPA-----LAQAGNVVPTVAP---LFGRPSPADH--------YRMEQLVSEQF---- 489
               :.:|:||.     :.:.|.::|....   ...||...:|        ..||:.|.:|.
  Fly  1022 GVGVGVPVPPGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFY 1086

  Fly   490 ------RHH------GFNLAAAAAAA--------------------------------------- 503
                  .||      ..|:|||||||
  Fly  1087 AQRQRSGHHVMRGRGASNVAAAAAAAAAAAAATVMAGGPGSSGFGSNHHHGHGHGSHGSHGHAPI 1151

  Fly   504 -----------------------QAQFNANGQVVGGVVSGSGEP-RPPSSSSSGSQRGSVPPAAL 544
                                   ||..:.:..|.|..:...|.| ..||...:||.:|:....|:
  Fly  1152 SEQVKCAILAQQLKAHKNTDLLQQALAHGSSSVAGNPLLHFGYPLTNPSPMHNGSSQGNGQATAM 1216

  Fly   545 ---PPPSLSSQQQQQQQQAVQ------------QQQQQGAQQQLQSAQQQQQSQQQSQQQQQITP 594
               .|..:..:.:.:....|:            :::....:.:.:....:|.::::::::|::.
  Fly  1217 DDDEPKLIIDEDENEHDHEVEAEDVDDFEEDEDEEEMDEPEDEPELILDEQPAEKEAEEEQELP- 1280

  Fly   595 GLVGGAGGSLKLEPQQMDFYSQRLRQLAGTTSPGAGSTVNSSSPSP-RQKQSPHFASPSPSQQQQ 658
                        :|.:.....:..:::|.|....|.......||.| ::..||  |:|:.:...|
  Fly  1281 ------------KPLEQLGTKEAAQKMAETILEQAIKAGKPLSPPPTKENASP--ANPTVATTMQ 1331

  Fly   659 QQLATIP--RPHS-----------------------------LTPPEKLGD-ASSENGSL----- 686
            :...|.|  .|.|                             |.|..||.| |:|:|...
  Fly  1332 EPAITAPSTNPSSLKTMIAQAEYVGKSLKEVASSPFKDESQDLVPVAKLVDNATSQNMGFNSYFR 1396

  Fly   687 --------------GLILAS-------------TPRSASTPPSKTGDVSLQEPIAHCYSCSYCDK 724
                          ||:.:.             |..|:|:.|.|....||   ..:..||.||.:
  Fly  1397 PSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSSSSEPKKKSAYSL---APNRVSCPYCQR 1458

  Fly   725 KFRFENNLIIHQRTHTGEKPYKCTACDF------ECS-HIQKLMKHMRVHRSPADDQDNQDNQDD 782
            .|.:.::|..|..||||:||:||:.|..      .|. |:  |.||..|..:.:.....:|..:.
  Fly  1459 MFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHL--LRKHGNVESAMSVYVPTEDVSEP 1521

  Fly   783 GSNADSLETNEADNDEDPNPDESEEELGDGDNDPDGDGDLDGEDEDEDELEECEDMDYKAEDLSV 847
            .....|:|..|.:........|.|:||               |.|.|.|||       :..:|..
  Fly  1522 IPVPKSVEEIELEEQRRRQEAEREKEL---------------ELERERELE-------RERELER 1564

  Fly   848 SNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQALQESGRKEAAAAAAAAAAAAD 912
            ..:::.:.:..:.          :|:.|..    ||.:.|           ..|||..|||:|.:
  Fly  1565 ERQLEKEKERERQ----------QLIQKLA----AQMNAA-----------ATAAAVVAAASAVN 1604

  Fly   913 NNNRGGAGAPLSDKLNG--LPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLF------------ 963
            ....||...|::|.|.|  ||.........||:.....:..:...|.....|.
  Fly  1605 GGASGGPHGPIADALAGGDLPYKCHLCEGSFAERLQCLEHIKQAHAHEYALLLAKGAIETESLEA 1669

  Fly   964 NPFPNPFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKKESRQRND 1028
            ||...|.:                ||:|.::.       .|.|.|.....       .:...|..
  Fly  1670 NPHQQPSQ----------------QAVHSDDE-------APNGGGNRGKY-------PDYSNRKV 1704

  Fly  1029 TCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTH-GRT------GKDVY 1086
            .|.||.:.|.:..:|..|.|:|:||:|::|::|.........:.||||.| ||.      |.|
  Fly  1705 ICAFCLRRFWSTEDLRRHMRTHSGERPFQCDICLRKFTLKHSMLRHMKKHSGRAHNGDTPGSD-- 1767

  Fly  1087 RCRFCDMPFSVPST 1100
             |...:...|.|||
  Fly  1768 -CSDDEQVSSPPST 1780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	7/21 (33%)
		C2H2 Zn finger	719..739	CDD:275368	6/19 (32%)
		zf-H2C2_2	731..756	CDD:338759	12/31 (39%)
		C2H2 Zn finger	747..767	CDD:275368	7/26 (27%)
		zf-C2H2	1029..1050	CDD:333835	7/20 (35%)
		C2H2 Zn finger	1030..1050	CDD:275368	7/19 (37%)
		zf-H2C2_2	1042..1067	CDD:338759	9/24 (38%)
		C2H2 Zn finger	1058..1078	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1088..1106	CDD:275368	5/13 (38%)
peb	NP_001014722.1	C2H2 Zn finger	252..272	CDD:275368
		C2H2 Zn finger	284..304	CDD:275368
		zf-H2C2_2	296..321	CDD:290200
		C2H2 Zn finger	312..332	CDD:275368
		C2H2 Zn finger	711..731	CDD:275368	0/19 (0%)
		C2H2 Zn finger	743..763	CDD:275368	3/19 (16%)
		zf-H2C2_2	755..780	CDD:290200	6/24 (25%)
		C2H2 Zn finger	771..789	CDD:275368	4/17 (24%)
		C2H2 Zn finger	1061..1079	CDD:275368	3/17 (18%)
		PopZ	1299..>1430	CDD:226348	23/132 (17%)
		C2H2 Zn finger	1453..1473	CDD:275370	6/19 (32%)
		zf-H2C2_2	1465..1490	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1481..1502	CDD:275370	5/22 (23%)
		C2H2 Zn finger	1706..1726	CDD:275368	7/19 (37%)
		zf-H2C2_2	1718..1742	CDD:290200	9/23 (39%)
		C2H2 Zn finger	1734..1754	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447774
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930