DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and Zfp217

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001101283.1	Gene:	Zfp217 / 311764	RGDID:	1308451	Length:	1039	Species:	Rattus norvegicus

Alignment Length:	1166	Identity:	228/1166 - (19%)
Similarity:	346/1166 - (29%)	Gaps:	411/1166 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 QPKQAKVKQE---PYDEEGVNHHQNQDDDDDEEMEERS--LAKRPKMELVDAEAN-TVHTEPSNY 268
            :|...:|:.|   |.| :|....:...:...:||||.|  :..:......|.|:: ..|.:...|
  Rat    86 EPAVLRVEAEYLSPLD-KGQVPTEPPKEKSSKEMEELSCDVCGQTFPVAFDVESHMKKHKDSFTY 149

  Fly   269 TCSTCKTRYTSAWRLIQHVQHSHGVKIYVESPGGGATLTVATPAALNNSALALAAAAAAASASGL 333
            .||.|..|:...|.|..|::..:|                             .:...:....|.
  Rat   150 GCSMCGRRFKEPWFLKNHMRTHNG-----------------------------KSGTRSKLQQGT 185

  Fly   334 ASPQPAVSPNPAVTSSAKRSSPLGAAGSTILSTSVSSTCSNSLVNTSGGSISNTSSIGSPQQQQL 398
            .||   |:.|..|.:.        |.|:......:...|.....|
  Rat   186 ESP---VTINDVVQAH--------APGNISTPYKICMVCGFLFPN-------------------- 219

  Fly   399 QLQQQQAQQQQQRVQQQQRENLASAMAA-GMRHHPLLPPPEAMHANPFQLLRMPLPPALAQAGNV 462
                :|:..:..:|..::....||:.|. |.:..|..|..|.:.   |..||   |.:.|::
  Rat   220 ----KQSLIEHSKVHAKETVPSASSTAPDGHQEEPTSPREELLQ---FLNLR---PRSTAES--- 271

  Fly   463 VPTVAPLFGRP--SPADHYRMEQLVSEQFRHHGFNLAAAAAAAQAQFNANGQV------------ 513
              ||.|:...|  .|...|:..||.::          ...|.||.:...:||.
  Rat   272 --TVKPMTSIPQLDPFTTYQAWQLATK----------GKVAVAQEEVKESGQEGSTDNDDSCSEK 324

  Fly   514 -------VGGVVSGSGEPRPPSSSSSG-------SQRGSVPPAALPPPSLSSQQQQQQQQAVQQQ 564
                   |||.|.|||:.:...||.||       |:.|:   :.:|.....|:....:::.....
  Rat   325 EELGEIWVGGKVEGSGKSKTNRSSCSGLSQDKDKSRHGN---SEVPSGDADSKLPGSKEKPTHCS 386

  Fly   565 QQQGAQQQLQSAQQQQQSQQQSQQQQQITPGLVGGAGGSLKLEPQQMDFYSQRLRQLAGTTSPGA 629
            :...|.:.........:..::.::....:|.:.|.|                  || .||.||..
  Rat   387 ECSKAFRTYHQLVLHSRVHRKDRRADAPSPTMAGDA------------------RQ-PGTCSPEL 432

  Fly   630 GSTVNSSSPSPRQKQSPHFASPSPSQQQQQQLATIPRPHSLTPPEKLGDASSENGSLGLILASTP 694
            .:|:..|....|:..|.                               |.|.:....||.|
  Rat   433 RTTLEESGAGDREGGSE-------------------------------DGSEDGLPEGLHL---- 462

  Fly   695 RSASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQK 759
                   .|..|....:|:.....||||.|.||....|.||.|||||||||||..|::..:....
  Rat   463 -------DKNDDGGKAKPLTSSRECSYCGKFFRSNYYLNIHLRTHTGEKPYKCEFCEYAAAQKTS 520

  Fly   760 LMKHMRVHR-------SPADDQD---NQDNQDDGSNADSLETNE----ADNDEDPN--------- 801
            |..|:..|.       :||:.:.   :|:.||....|||.:|..    .|..:|..
  Rat   521 LRYHLERHHKDKQLGDAPAESKSEGRSQEPQDMLLTADSAQTKNLKRFLDGAKDVKGSPPAKLLK 585

  Fly   802 --PDESEEELGDGDNDPDGDGDL-DGEDEDEDELEECEDMDYKAE-DLSVSNRIDGKSQSPKTTS 862
              |...:..||.....|..:.|. |......|..|:.......|. |:......|.::.||....
  Rat   586 EMPSVFQSVLGSTVLSPAHNKDTQDFHKNAADGAEKVRKSPAPAYLDMPRKKTGDPRASSPACKL 650

  Fly   863 SGATSLV-----GELMDKFGLSNIAQYSEAYKQALQESGRKEAAAAAAAAAAAADNNNRGGAGA- 921
            .|...|.     ||.||:                                  .||..::.||..
  Rat   651 EGVGPLAREAGHGEKMDR----------------------------------EADYRHKPGADCQ 681

  Fly   922 --PLSDKLNGL---PVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNPFPNPFELSKRMKMDGG 981
              ||:..|..|   |..:|       ..|.:         ||....|..|...:.
  Rat   682 DRPLNLSLGALHACPAISL-------SKCLI---------PSIACPFCTFKTFYP---------- 720

  Fly   982 DWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKKESRQRNDTCEFCGKVFKNCSNLTVH 1046
                        |.|..:.:|                   |.|...||       .||||:.:|.
  Rat   721 ------------EVLMMHQRL-------------------EHRYNPDT-------HKNCSSKSVL 747

  Fly  1047 RRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVP--STLEKHMRKCV 1109
            |...||..|                       ...||||........|.:.|  |:..|.:....
  Rat   748 RNRRTGCPP-----------------------ALLGKDVPPLSGLHKPKAKPAFSSQAKALHPEK 789

  Fly  1110 VNQGKAA-AAANAVAAAQAAQAAAQHIQAAAQQAQAVQAQAVQAQAAQQSQQQQQQLSPMGVV-- 1171
            |.||.:. ..|...:....:..|..::::...|..|....|        ::|||.:|.|.|.|
  Rat   790 VRQGTSGPGKAPQTSGPDNSTLAPSNLKSHRSQPSAGGPSA--------TRQQQSELFPKGGVPA 846

  Fly  1172 ------------GYPPQFVSGHNLSLPGSVSGD----------------NDSNASSSMTGVHPIS 1208
                        ..||...:...|| .|:.:|.                |..:|:|..:..||..
  Rat   847 AMDKAKRPEPKLKAPPAPPAQSPLS-SGNGNGSAECPWGQQGRDYYCQRNAGSATSEYSEPHPKR 910

  Fly  1209 LKEEAXLFS----------GFPVP----------LAPP-----PPLQQHQPHLQQPQQQQT 1244
            ||.......          ||.:|          |.||     ||:...:.....|.:.::
  Rat   911 LKSPVVSLDTEHPGPNGRRGFELPKYHVVRSITSLLPPEYVCSPPVLPPKARFLSPGEVES 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	11/21 (52%)
		C2H2 Zn finger	719..739	CDD:275368	11/19 (58%)
		zf-H2C2_2	731..756	CDD:338759	15/24 (63%)
		C2H2 Zn finger	747..767	CDD:275368	4/19 (21%)
		zf-C2H2	1029..1050	CDD:333835	7/20 (35%)
		C2H2 Zn finger	1030..1050	CDD:275368	6/19 (32%)
		zf-H2C2_2	1042..1067	CDD:338759	5/24 (21%)
		C2H2 Zn finger	1058..1078	CDD:275368	0/19 (0%)
		C2H2 Zn finger	1088..1106	CDD:275368	4/19 (21%)
Zfp217	NP_001101283.1	C2H2 Zn finger	123..143	CDD:275368	2/19 (11%)
		C2H2 Zn finger	151..171	CDD:275368	7/19 (37%)
		zf-C2H2	151..171	CDD:395048	7/19 (37%)
		C2H2 Zn finger	210..230	CDD:275368	3/43 (7%)
		C2H2 Zn finger	385..405	CDD:275368	1/19 (5%)
		zf-C2H2	479..500	CDD:395048	11/20 (55%)
		C2H2 Zn finger	480..500	CDD:275370	11/19 (58%)
		zf-H2C2_2	492..517	CDD:404364	15/24 (63%)
		zf-H2C2_5	506..530	CDD:404746	7/23 (30%)
		C2H2 Zn finger	508..529	CDD:275370	4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910