DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and Bcl11a

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001178612.1	Gene:	Bcl11a / 305589	RGDID:	1309923	Length:	835	Species:	Rattus norvegicus

Alignment Length:	1199	Identity:	310/1199 - (25%)
Similarity:	424/1199 - (35%)	Gaps:	511/1199 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DHGFRSLSHSDSTENDAVATQDILTCGACQKAFALSDIVKFIQHKVLQCNKENYGQCATQNPQMD 75
            |||.......|         .|:||||.||..|.|.||:.||:||..|||    |...
  Rat    32 DHGPLGAPEGD---------HDLLTCGQCQMNFPLGDILIFIEHKRKQCN----GSLC------- 76

  Fly    76 RDAEEGRPLSLVNRRPSISAPISGRKSAPASAAAAVAAAAAAAAAAAAASSTASGSRIHTPPPSP 140
              .|:|     |::.||                                             |||
  Rat    77 --LEKG-----VDKPPS---------------------------------------------PSP 89

  Fly   141 ADLLADGASSTPKRLVDENDNTTPKDSETGATTLDSNAAPSSPAAIERQSSGDSSCEMEEQQDRQ 205
            .::   ..:|.|   |:.....||:|.:..:|                  |....|
  Rat    90 IEM---KKASNP---VEVGIQVTPEDDDCLST------------------SSRGIC--------- 121

  Fly   206 DKQSQPKQAKVKQEPYDEEGVNHHQNQDDDDDEEMEERSLAKRPKMELVDAEANTVHTEPSNYTC 270
                 |||..:..:.....|::..::         ...:|...|.|....|.......|||:|||
  Rat   122 -----PKQEHIADKLLHWRGLSSPRS---------AHGALIPTPGMSAEYAPQGICKDEPSSYTC 172

  Fly   271 STCKTRYTSAWRLIQHVQHSHGVKIYVESPGGGATLTVATPAALNNSALALAAAAAAASASGLAS 335
            :|||..:||||.|:||.|::||::||:||..|
  Rat   173 TTCKQPFTSAWFLLQHAQNTHGLRIYLESEHG--------------------------------- 204

  Fly   336 PQPAVSPNPAVTSSAKRSSPLGAAGSTILSTSVSSTCSNSLVNTSGGSISNTSSIGSPQQQQLQL 400
                              |||                              |..:|.|
  Rat   205 ------------------SPL------------------------------TPRVGIP------- 214

  Fly   401 QQQQAQQQQQRVQQQQRENLASAMAAGMRHHPLLPPPEAMHANPFQLLRMP---LPPALAQAGNV 462
                                 |.:.|.....|.|........|||.|||:|   ...|...|...
  Rat   215 ---------------------SGLGAECPSQPSLHGIPIADNNPFNLLRIPGSVSREASGLAEGR 258

  Fly   463 VPTVAPLFGRPSPADH---YRMEQLVSEQF---RHHGFNLAAAAAAAQAQFNANGQVVGGVVSGS 521
            .|...|||. |.|..|   :|:|:|.:|:.   .||
  Rat   259 FPPTPPLFS-PPPRHHLDPHRIERLGAEEMALATHH----------------------------- 293

  Fly   522 GEPRPPSSSSSGSQRGSVPPAALPPPSLSSQQQQQQQQAVQQQQQQGAQQQLQSAQQQQQSQQQS 586
                               |:|.
  Rat   294 -------------------PSAF------------------------------------------ 297

  Fly   587 QQQQQITPGLVGGAGGSLKLEPQQMDFYSQRLRQLAGTTSPGAGSTVNSSSP--SPRQKQSPHFA 649
            .:..::.|         :.:||..||| |:|||:|||          |:|||  ||        .
  Rat   298 DRVLRLNP---------MAMEPPAMDF-SRRLRELAG----------NTSSPPLSP--------G 334

  Fly   650 SPSPSQQQQQQLATIPRPHSL-TPPEKLGDASSENGSLGLILASTPRSASTPPSKTGDVSLQEPI 713
            .|||.|:..|......:|..| |||                  ..|..::.|||        :|.
  Rat   335 RPSPMQRLLQPFQPGSKPPFLATPP------------------LPPLQSAPPPS--------QPP 373

  Fly   714 AHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPADDQDNQD 778
            ....||.:|.|.|:|::||::|:|:|||||||||..||..|:...||.:||:.|...:.....:
  Rat   374 VKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVK- 437

  Fly   779 NQDDG-SNADSLETNEAD-----------------NDEDPN--PDESEEELGDGDNDPDGDGDLD 823
             .||| |.|.|.|...:|                 ::.|||  |     |.||.:.:.|.:.:.:
  Rat   438 -SDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIP-----ENGDEEEEEDDEEEEE 496

  Fly   824 GEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVG-------ELMDKFGLSNI 881
            .|:|:|:||.|.|.:|| ...||:.     .::..:.:|.||...||       ::|....||::
  Rat   497 EEEEEEEELTESERVDY-GFGLSLE-----AARHHENSSRGAVVGVGDEGRALPDVMQGMVLSSM 555

  Fly   882 AQYSEAYKQALQESGRKEAAAAAAAAAAAADNNNRGGAGAPLSD-KLNGLPVAALRLRDEFAKNC 945
            ..:|||:.|.|.|..::...|.|.......|.::..|....:.| .:||             :.|
  Rat   556 QHFSEAFHQVLGEKHKRSHLAEAEGHRDTCDEDSVAGESDRIDDGTVNG-------------RGC 607

  Fly   946 NMFQQPQDG-------GAPSQVPLFNPFPNPFELSKRMKMDG----------------GDW---W 984
            :..:....|       |:||.:       :||  |||:|::.                ..|   :
  Rat   608 SPGESASGGLSKKLLLGSPSSL-------SPF--SKRIKLEKEFDLPPAAMPNTENVYSQWLAGY 663

  Fly   985 GMSQALHRNEALFENLKLKPL--------------------------------GLGGANSLIQGP 1017
            ..|:.|......|.:.:..|.                                |.||:...|.||
  Rat   664 AASRQLKDPFLTFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGP 728

  Fly  1018 ----LLKKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTH 1078
                ...||.| |:||||:|||||||||||||||||||||:|||||||:||||||||||||||||
  Rat   729 GPGRPSSKEGR-RSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTH 792

  Fly  1079 GRTGKDVYRCRFCDMPFSVPSTLEKHMRK 1107
            |:.|||||:|..|.|||||.|||||||:|
  Rat   793 GQVGKDVYKCEICKMPFSVYSTLEKHMKK 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	10/21 (48%)
		C2H2 Zn finger	719..739	CDD:275368	9/19 (47%)
		zf-H2C2_2	731..756	CDD:338759	16/24 (67%)
		C2H2 Zn finger	747..767	CDD:275368	8/19 (42%)
		zf-C2H2	1029..1050	CDD:333835	19/20 (95%)
		C2H2 Zn finger	1030..1050	CDD:275368	18/19 (95%)
		zf-H2C2_2	1042..1067	CDD:338759	22/24 (92%)
		C2H2 Zn finger	1058..1078	CDD:275368	18/19 (95%)
		C2H2 Zn finger	1088..1106	CDD:275368	13/17 (76%)
Bcl11a	NP_001178612.1	zf-C2H2	378..399	CDD:395048	10/20 (50%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:404364	16/24 (67%)
		C2H2 Zn finger	407..427	CDD:275368	8/19 (42%)
		zf-C2H2	743..764	CDD:395048	19/20 (95%)
		C2H2 Zn finger	744..764	CDD:275368	18/19 (95%)
		zf-H2C2_2	756..781	CDD:404364	22/24 (92%)
		C2H2 Zn finger	772..792	CDD:275368	18/19 (95%)
		C2H2 Zn finger	802..820	CDD:275368	13/17 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4601
eggNOG	1	0.900	-	-		E33208_3BE4M
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2044
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D121311at33208
OrthoFinder	1	1.000	-	-		FOG0002010
OrthoInspector	1	1.000	-	-		otm46020
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45993
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1492
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.930