DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9650 and Zfp189

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001276830.1	Gene:	Zfp189 / 230162	MGIID:	2444707	Length:	608	Species:	Mus musculus

Alignment Length:	626	Identity:	131/626 - (20%)
Similarity:	210/626 - (33%)	Gaps:	166/626 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   649 ASPSPSQQQQQQLATI-PRPHSL--------------------------TPPEKL---------- 676
            |||||..:.:::...: |.|.||                          |..|:|
Mouse     2 ASPSPPLEPKEEWGYLDPAPRSLYKDVMMDSYGKLVSLDVLNRNKDEEPTVKEELEKDIEPQGVI 66

  Fly   677 ----------GDASSENGSL--------GLILASTPRSASTPPSK--TGDVSLQE-PIAH--CYS 718
                      ....||...|        |:.|...||.:.:...|  .|..:::: |.:.  |:.
Mouse    67 VTRIKSEIDQDPVGSETFELVGRLDKQRGIFLWEIPRDSLSEEQKLFRGHTNVRKRPTSEEKCHK 131

  Fly   719 CSYCDKKFRFENNLIIHQRTHTGEKPYKCTAC---------------------DFECSHIQK--- 759
            |..|.|:|..:.:.|.|||.||||||::|..|                     .:||::..|
Mouse   132 CEECGKRFVRKAHFIQHQRVHTGEKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFS 196

  Fly   760 ----LMKHMRVHRSPADDQDNQDNQDDGSNADSLETNEADNDEDPNPDES-------EEELGDGD 813
                |::|.|:|......|.||..|........::.......|.|:....       :..|.:..
Mouse   197 VSSTLIRHQRIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQ 261

  Fly   814 NDPDGDGDLDGEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGL 878
            ....|        |......:|: ..:....|.|.::.....:.|..        .||....|.|
Mouse   262 RTHTG--------EKPYHCTKCK-KSFSRNSLLVEHQRIHTGERPHK--------CGECGKAFRL 309

  Fly   879 SN-IAQYSEAYKQALQESGRK-----EAAAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRL 937
            |. :.|:.:.:      :|.|     |...:.:.::...::........|...:..|
Mouse   310 STYLIQHQKIH------TGEKPFLCIECGKSFSRSSFLIEHQRIHTGERPYQCQECG-------- 360

  Fly   938 RDEFAKNCNM--FQQPQDGGAPSQVPLFNPFPNPFELSKRMKMDGGDWWGMSQALHRNEALFENL 1000
             ..|::.||:  .|:...|..|.:..         |..|......|  ....|.:|..|......
Mouse   361 -KSFSQLCNLTRHQRIHTGDKPHKCE---------ECGKAFSRSSG--LIQHQRIHIREKTSPFS 413

  Fly  1001 KLKPLGLGGANSLIQGPLLKKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYAC 1065
            :.|.......:.:||..:..||...:   |:.|||.|...::|..|:|.|||||||.|.:|..:.
Mouse   414 ETKESFDPNCSLVIQQEVSPKEKSYK---CDDCGKTFSVSAHLVQHQRIHTGEKPYLCTVCGKSF 475

  Fly  1066 AQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEKHM--------RKCVVNQGKAAAAANAV 1122
            ::||.|..|.:.|  ||:..|.||.|...||....|.:|.        .|| ...|||.:..:.:
Mouse   476 SRSSFLIEHQRIH--TGERPYLCRQCGKSFSQLCNLIRHQGVHTGNKPHKC-EECGKAFSRNSGL 537

  Fly  1123 AAAQAAQAAAQHIQAA------AQQAQAVQAQAVQAQAAQQ 1157
            ...|......:..:..      :||...|..|.:.|:...|
Mouse   538 IQHQRIHTGEKPYRCGKCDKSFSQQRSLVNHQKIHAEVKTQ 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	8/21 (38%)
		C2H2 Zn finger	719..739	CDD:275368	8/19 (42%)
		zf-H2C2_2	731..756	CDD:338759	14/45 (31%)
		C2H2 Zn finger	747..767	CDD:275368	8/47 (17%)
		zf-C2H2	1029..1050	CDD:333835	8/20 (40%)
		C2H2 Zn finger	1030..1050	CDD:275368	8/19 (42%)
		zf-H2C2_2	1042..1067	CDD:338759	12/24 (50%)
		C2H2 Zn finger	1058..1078	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1088..1106	CDD:275368	7/25 (28%)
Zfp189	NP_001276830.1	KRAB_A-box	<12..39	CDD:143639	4/26 (15%)
		COG5048	116..506	CDD:227381	96/437 (22%)
		C2H2 Zn finger	132..152	CDD:275368	8/19 (42%)
		zf-H2C2_2	144..169	CDD:290200	12/24 (50%)
		C2H2 Zn finger	160..180	CDD:275368	2/19 (11%)
		zf-H2C2_2	175..196	CDD:290200	3/20 (15%)
		C2H2 Zn finger	188..208	CDD:275368	5/19 (26%)
		zf-H2C2_2	201..225	CDD:290200	8/23 (35%)
		C2H2 Zn finger	216..236	CDD:275368	3/19 (16%)
		zf-H2C2_2	228..252	CDD:290200	2/23 (9%)
		C2H2 Zn finger	244..264	CDD:275368	1/19 (5%)
		zf-H2C2_2	256..281	CDD:290200	4/33 (12%)
		C2H2 Zn finger	272..292	CDD:275368	3/20 (15%)
		zf-H2C2_2	285..307	CDD:290200	4/29 (14%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		zf-H2C2_2	312..337	CDD:290200	4/30 (13%)
		C2H2 Zn finger	328..348	CDD:275368	1/19 (5%)
		zf-H2C2_2	341..365	CDD:290200	3/32 (9%)
		C2H2 Zn finger	356..376	CDD:275368	5/28 (18%)
		zf-H2C2_2	368..393	CDD:290200	6/33 (18%)
		C2H2 Zn finger	384..404	CDD:275368	4/30 (13%)
		C2H2 Zn finger	440..460	CDD:275368	8/19 (42%)
		zf-H2C2_2	452..477	CDD:290200	12/24 (50%)
		C2H2 Zn finger	468..488	CDD:275368	6/19 (32%)
		zf-H2C2_2	481..505	CDD:290200	10/25 (40%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		zf-H2C2_2	508..533	CDD:290200	7/25 (28%)
		C2H2 Zn finger	524..544	CDD:275368	5/20 (25%)
		zf-H2C2_2	537..561	CDD:290200	1/23 (4%)
		C2H2 Zn finger	552..572	CDD:275368	4/19 (21%)
		C2H2 Zn finger	583..603	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000