DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and Zscan2

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001369440.1	Gene:	Zscan2 / 22691	MGIID:	99176	Length:	614	Species:	Mus musculus

Alignment Length:	633	Identity:	138/633 - (21%)
Similarity:	205/633 - (32%)	Gaps:	183/633 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   523 EPRPPSSSSSGSQRGSV---PPAALP----------PPSLSSQQQ------QQQQQAVQQQQQQG 568
            ||.|.|:.....|....   |..||.          .|.:.:::|      ::.|..:|:.:.:.
Mouse    52 EPFPQSAGKGSPQEEDAAEGPQGALVRFRELCRRWLRPEVHTKEQMLTVLPREIQAWLQEHRPES 116

  Fly   569 AQQQLQSAQQQQQSQQQSQQQQQITPG-------------------LVGGAGGSLKLEPQQMDFY 614
            :::.:...:...|:.:.|..:.|...|                   :.||.||      ||.|..
Mouse   117 SEEAVALVEDLTQTFRHSDFEIQSENGENSNEDMFEGVESHGMFLNISGGEGG------QQSDGD 175

  Fly   615 SQRLRQLAGTTSPGAGSTVNSSSPSPRQKQSPHFASPSPSQQQQQQLATIPRPHSLTPPEKLGDA 679
            |...|...     ..|:..::....||       ..||..::..|.:.        .....||:.
Mouse   176 SDFERDCG-----SGGAQGHAPGEDPR-------VVPSEGREVGQLIG--------LQGTYLGEK 220

  Fly   680 SSENGSLGLILASTPRSASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKP 744
            ..|....|...:......:...:.||:        ..|.|..|.|.|...:|...||.|||||||
Mouse   221 PYECPQCGKTFSRKSHLITHERTHTGE--------KYYKCDECGKSFSDGSNFSRHQTTHTGEKP 277

  Fly   745 YKCTACDFECSHIQKLMKHMRVHRSPADDQDNQDNQDDGSNADSLETNEADNDEDP-NPDESEEE 808
            |||..|....|....|:.|.|:|......|..:..:....:.:.:........|.| :..|..:.
Mouse   278 YKCRDCGKSFSRSANLITHQRIHTGEKPFQCAECGKSFSRSPNLIAHQRTHTGEKPYSCPECGKS 342

  Fly   809 LGDGDNDPDGDGDLDGEDEDEDELEEC-EDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGEL 872
            .|:..:.....|...|  |.....:|| |...|.: :|....||....:..|.|..|
Mouse   343 FGNRSSLNTHQGIHTG--EKPYACKECGESFSYNS-NLIRHQRIHTGEKPYKCTECG-------- 396

  Fly   873 MDKFGLSNIAQYSEAYKQALQESGRKEAAAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRL 937
             .||     :|.|.........:|.|                                |......
Mouse   397 -QKF-----SQSSALITHRRTHTGEK--------------------------------PYQCGEC 423

  Fly   938 RDEFAKNCNMFQQPQDGGAPSQVPLFNPFPNPFELSKRMKMDGGDWWGMSQALHRNEALFENLKL 1002
            ...|:::.|:                                         |.||...|.|
Mouse   424 GKNFSRSSNL-----------------------------------------ATHRRTHLVE---- 443

  Fly  1003 KP--LGLGG-----ANSLI--QGPLLKKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKC 1058
            ||  .||.|     ::|||  ||    ..:.::...|..||:.|...|||..|:|:|||||||:|
Mouse   444 KPYKCGLCGKSFSQSSSLIAHQG----THTGEKPYECLTCGESFSWSSNLIKHQRTHTGEKPYRC 504

  Fly  1059 ELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEKHMR 1106
            ..|....:|.|:|..|.:||  ||:..|:|..|...||..|.|..|.|
Mouse   505 GDCGKGFSQRSQLVVHQRTH--TGEKPYKCLMCGKSFSRGSILVMHQR 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	8/21 (38%)
		C2H2 Zn finger	719..739	CDD:275368	7/19 (37%)
		zf-H2C2_2	731..756	CDD:338759	14/24 (58%)
		C2H2 Zn finger	747..767	CDD:275368	6/19 (32%)
		zf-C2H2	1029..1050	CDD:333835	9/20 (45%)
		C2H2 Zn finger	1030..1050	CDD:275368	9/19 (47%)
		zf-H2C2_2	1042..1067	CDD:338759	13/24 (54%)
		C2H2 Zn finger	1058..1078	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1088..1106	CDD:275368	7/17 (41%)
Zscan2	NP_001369440.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..73		5/20 (25%)
		SCAN	69..131	CDD:396558	8/61 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..200		12/55 (22%)
		COG5048	220..600	CDD:227381	105/439 (24%)
		C2H2 Zn finger	224..244	CDD:275368	1/19 (5%)
		C2H2 Zn finger	252..272	CDD:275368	7/19 (37%)
		C2H2 Zn finger	280..300	CDD:275368	6/19 (32%)
		C2H2 Zn finger	308..328	CDD:275368	0/19 (0%)
		C2H2 Zn finger	336..356	CDD:275368	3/19 (16%)
		C2H2 Zn finger	364..384	CDD:275368	6/20 (30%)
		C2H2 Zn finger	392..412	CDD:275368	6/33 (18%)
		C2H2 Zn finger	420..440	CDD:275368	5/60 (8%)
		C2H2 Zn finger	448..468	CDD:275368	8/23 (35%)
		C2H2 Zn finger	476..496	CDD:275368	9/19 (47%)
		C2H2 Zn finger	504..524	CDD:275368	6/19 (32%)
		C2H2 Zn finger	532..552	CDD:275368	8/19 (42%)
		C2H2 Zn finger	560..580	CDD:275368
		C2H2 Zn finger	588..608	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000