DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and Zfp658

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001008549.1	Gene:	Zfp658 / 210104	MGIID:	2652821	Length:	887	Species:	Mus musculus

Alignment Length:	849	Identity:	168/849 - (19%)
Similarity:	274/849 - (32%)	Gaps:	274/849 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 SPQQQQLQLQQQQ----------------AQQQQQRVQQQQRENLASAMAAGMRH-----HPLLP 435
            |.:.|:|..|:|:                :|::.:|:...||......|.....|     :| :|
Mouse     4 SQKAQRLHPQEQEGSRERLVSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHLLAVGYP-VP 67

  Fly   436 PPEAMHANPFQLLRMPLPPALAQAGNV-VPTVAPLFGRPSPADHYRMEQLVSEQFRHHGFNLAAA 499
            .|.|:    |::.:.    ..|:.|.. :|  .|.:.:...::.||.:|..||:         ||
Mouse    68 SPGAI----FRIKKR----KEARTGEAKLP--HPCWCQEVESEFYRPQQKASEE---------AA 113

  Fly   500 AAAAQAQFNANGQVVGGVVSGSGEPRPPSSSSSGSQRGSVPPAALPPPSLSSQQQQQQQQAVQQQ 564
            ...::|.......:...::....:...|:.....:|   :||.: |..||:.:..:..:....::
Mouse   114 FQTSKASAVTRHGLWCSILEELWQDPDPAQRDGQNQ---IPPWS-PGASLNKKTARADRDCGWKE 174

  Fly   565 -------------QQQGAQQQLQSAQQQQQSQQQSQQQQQITPGLVGGAGGSLKLEPQQMDFYSQ 616
                         .|:|| .:|.:.:.....:...::|..:|..| .|...|..|.||  |..:.
Mouse   175 PGKTTPFVANLFSTQKGA-PRLLAKRLNPNLEANGEEQGSVTKQL-NGLVTSAHLLPQ--DSSNA 235

  Fly   617 RLRQLAGTTSPGAGSTVNSSSPSPRQKQSPHFASPSPSQQQQQQLATIPRPHSLTPPEKLGDASS 681
            ....|..|.:|..|   |.....|..||                 .|....||   .|||.:.:.
Mouse   236 NCTILRETWNPCKG---NQCRKVPTHKQ-----------------LTEKEAHS---REKLDEGTE 277

  Fly   682 ------ENGSLGLILASTPRSASTPPSKTGDVSLQ--EPIAH-------CYSCSYCDKKFRFENN 731
                  :..:.....|:..........|.|:..||  |..:|       .|.|..|.|.|...:|
Mouse   278 CRKVFYDESAFCKHQAAHAGEGPFVCHKCGEAFLQKTEFASHQETHPEKPYECPDCGKSFSRTSN 342

  Fly   732 LIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRS------PADDQDNQDNQDDGSNADSLE 790
            |.:|.|.|||||||:|..|....::..:|..|.|:|..      |...:..:..       ..|.
Mouse   343 LQVHHRIHTGEKPYECRDCGKSFNNTSQLKVHYRIHTGERPYVCPVCGKAFKQK-------SILS 400

  Fly   791 TNEA-DNDEDP----------------------NPDESEEELGDGDNDPDGDGDLDGEDEDEDEL 832
            |:|. ...|.|                      :..|...|.||
Mouse   401 THETIHTGEKPYKCTVCGKLFSCTSRLKVHYQIHMKEKPYECGD--------------------- 444

  Fly   833 EECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQALQESGR 897
              |.....:...|:|..:|..:....:.:..|.|              ..|.||.........|:
Mouse   445 --CGKAFKRKSSLTVHQKIHIRQTHHECSECGKT--------------FNQKSELSTHQRLHLGK 493

  Fly   898 KEAAAAAAAAAAAADNNNR-GGAGAPLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQV- 960
                           |::| ...|...:                :|....|.::...|..|.:.
Mouse   494 ---------------NSHRCSDCGKSFT----------------YASQLKMHRRVHTGEKPYKCR 527

  Fly   961 PLFNPFPNPFELSKRMKMDGGDWWGMSQALHRNE----------ALFENLKL----------KPL 1005
            .....|...|.|:            :.:.:|:.|          ||....:|          ||.
Mouse   528 DCGKSFTYSFTLN------------VHRRIHKVEKPHKCSICGKALASKYQLEEHERIHTGEKPY 580

  Fly  1006 -------GLGGANSLIQGPLLKKESR------------QRND--------------TCEFCGKVF 1037
                   |..|.:..::..:.....:            ||:.              ||.:|||.|
Mouse   581 VCTECGKGFHGRSGFLRHQITHTRDKPFVCHKCGKAFFQRSQLTSHQQTHTGEKPYTCHYCGKSF 645

  Fly  1038 KNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLE 1102
            .:.|.||||.|.||||:||||:.|:.:.:.||:|..|::.|  ||:..|.|..|...||..|:|.
Mouse   646 SHTSQLTVHHRIHTGERPYKCDYCAKSFSNSSQLKEHLRIH--TGETPYACSECGKAFSRRSSLN 708

  Fly  1103 KHMR 1106
            .|.:
Mouse   709 LHTK 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	9/21 (43%)
		C2H2 Zn finger	719..739	CDD:275368	8/19 (42%)
		zf-H2C2_2	731..756	CDD:338759	13/24 (54%)
		C2H2 Zn finger	747..767	CDD:275368	5/19 (26%)
		zf-C2H2	1029..1050	CDD:333835	12/20 (60%)
		C2H2 Zn finger	1030..1050	CDD:275368	11/19 (58%)
		zf-H2C2_2	1042..1067	CDD:338759	14/24 (58%)
		C2H2 Zn finger	1058..1078	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1088..1106	CDD:275368	7/17 (41%)
Zfp658	NP_001008549.1	KRAB	23..80	CDD:214630	11/65 (17%)
		C2H2 Zn finger	275..295	CDD:275368	1/19 (5%)
		COG5048	300..684	CDD:227381	94/470 (20%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	8/19 (42%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..406	CDD:275368	4/26 (15%)
		C2H2 Zn finger	414..434	CDD:275368	0/19 (0%)
		C2H2 Zn finger	442..462	CDD:275368	5/42 (12%)
		C2H2 Zn finger	470..490	CDD:275368	5/33 (15%)
		COG5048	493..887	CDD:227381	57/265 (22%)
		C2H2 Zn finger	498..518	CDD:275368	3/35 (9%)
		C2H2 Zn finger	526..546	CDD:275368	3/31 (10%)
		C2H2 Zn finger	554..574	CDD:275368	3/19 (16%)
		C2H2 Zn finger	582..602	CDD:275368	2/19 (11%)
		C2H2 Zn finger	610..630	CDD:275368	2/19 (11%)
		C2H2 Zn finger	638..658	CDD:275368	11/19 (58%)
		C2H2 Zn finger	666..686	CDD:275368	6/19 (32%)
		C2H2 Zn finger	694..714	CDD:275368	7/19 (37%)
		C2H2 Zn finger	722..742	CDD:275368
		C2H2 Zn finger	750..770	CDD:275368
		C2H2 Zn finger	778..798	CDD:275368
		C2H2 Zn finger	806..826	CDD:275368
		C2H2 Zn finger	834..854	CDD:275368
		C2H2 Zn finger	862..882	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000