DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and ZNF721

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_597731.2	Gene:	ZNF721 / 170960	HGNCID:	29425	Length:	923	Species:	Homo sapiens

Alignment Length:	522	Identity:	119/522 - (22%)
Similarity:	185/522 - (35%)	Gaps:	159/522 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   630 GSTVNSSSPSPRQKQSPHFASP------------SPSQQQQQQLATIPRPHSLTPPEKLGDASSE 682
            |..::|||...:.|:......|            |.:..:.:::.|..:|::.   |..|.|..:
Human   255 GKVISSSSSFAKHKRIHTGEKPFKCLECGKAFNISTTLTKHRRIHTGEKPYTC---EVCGKAFRQ 316

  Fly   683 NGSLGLILASTPRSASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKC 747
            :.:|     ...|...|.         ::|    |:|..|.|.||...||.:|:|.|||||||||
Human   317 SANL-----YVHRRIHTG---------EKP----YTCGECGKTFRQSANLYVHRRIHTGEKPYKC 363

  Fly   748 TACDFECSHIQKLMKHMRVHRSPADDQDNQDNQDDGSNADSLETNEADNDEDPNPDESEEELGDG 812
            ..|.........|.:|.::|..
Human   364 EDCGKAFGRYTALNQHKKIHTG------------------------------------------- 385

  Fly   813 DNDPDGDGDLDGEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFG 877
                          |...:.|||......:.:|:...||..: :.|.|......:        ||
Human   386 --------------EKPYKCEECGKAFNSSTNLTAHKRIHTR-EKPYTCEDRGRA--------FG 427

  Fly   878 LS-NIAQY------SEAYKQALQESGRKEAAAAAAAAAAAADNNNRGGAG-APLSDKLNGLPVAA 934
            || |:.:|      .:.||  .:|.|:      |...:...:.:.:...| .|...|..|..:.:
Human   428 LSTNLNEYKKIHTGDKPYK--CKECGK------AFIHSLHLNKHEKIHTGKKPYKCKQCGKVITS 484

  Fly   935 LRLRDEFAKNCNMFQQPQDGGAPSQ-VPLFNPFPNPFELSKRMKMDGGDWWGMSQALHRNEALFE 998
               ...|||:    ::...|..|.: :.....|.:...|:|..::..|:
Human   485 ---SSSFAKH----KRIHTGEKPFECLECGKAFTSSTTLTKHRRIHTGE---------------- 526

  Fly   999 NLKLKP-----LGLGGANSLIQGPLLKKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKC 1058
                ||     .|.....|.|.....:..:.::..|||.|||.|:..:||.||||.|||||||||
Human   527 ----KPYTCEVCGKAFRQSAILYVHRRIHTGEKPYTCEECGKTFRQSANLYVHRRIHTGEKPYKC 587

  Fly  1059 ELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEKHMR--------KCVVNQGKA 1115
            |.|..|..:.:.|.:|.|.|  ||:.:|:|..|...|...:.|.:..:        || ...|||
Human   588 EECGKAFGRYTDLNQHKKIH--TGEKLYKCEECGKDFVWYTDLNQQKKIYTGEKPYKC-EECGKA 649

  Fly  1116 AA 1117
            .|
Human   650 FA 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	10/21 (48%)
		C2H2 Zn finger	719..739	CDD:275368	9/19 (47%)
		zf-H2C2_2	731..756	CDD:338759	14/24 (58%)
		C2H2 Zn finger	747..767	CDD:275368	4/19 (21%)
		zf-C2H2	1029..1050	CDD:333835	13/20 (65%)
		C2H2 Zn finger	1030..1050	CDD:275368	12/19 (63%)
		zf-H2C2_2	1042..1067	CDD:338759	18/24 (75%)
		C2H2 Zn finger	1058..1078	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1088..1106	CDD:275368	4/17 (24%)
ZNF721	NP_597731.2	C2H2 Zn finger	83..103	CDD:275368
		COG5048	93..492	CDD:227381	66/338 (20%)
		C2H2 Zn finger	111..131	CDD:275368
		C2H2 Zn finger	139..159	CDD:275368
		zf-H2C2_2	151..176	CDD:290200
		C2H2 Zn finger	167..187	CDD:275368
		C2H2 Zn finger	223..243	CDD:275368
		zf-H2C2_2	235..257	CDD:290200	1/1 (100%)
		C2H2 Zn finger	251..271	CDD:275368	5/15 (33%)
		C2H2 Zn finger	279..299	CDD:275368	1/19 (5%)
		zf-H2C2_2	292..316	CDD:290200	5/26 (19%)
		C2H2 Zn finger	307..327	CDD:275368	5/27 (19%)
		zf-H2C2_2	319..344	CDD:290200	9/42 (21%)
		C2H2 Zn finger	335..355	CDD:275368	9/19 (47%)
		zf-H2C2_2	347..372	CDD:290200	14/24 (58%)
		C2H2 Zn finger	363..383	CDD:275368	4/19 (21%)
		zf-H2C2_2	375..400	CDD:290200	7/81 (9%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		COG5048	442..885	CDD:227381	65/248 (26%)
		C2H2 Zn finger	447..467	CDD:275368	3/25 (12%)
		C2H2 Zn finger	475..495	CDD:275368	5/26 (19%)
		zf-H2C2_2	487..512	CDD:290200	6/28 (21%)
		C2H2 Zn finger	503..523	CDD:275368	3/19 (16%)
		zf-H2C2_2	516..540	CDD:290200	6/43 (14%)
		C2H2 Zn finger	531..551	CDD:275368	3/19 (16%)
		zf-H2C2_2	544..568	CDD:290200	7/23 (30%)
		C2H2 Zn finger	559..579	CDD:275368	12/19 (63%)
		zf-H2C2_2	571..596	CDD:290200	18/24 (75%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..634	CDD:275368	4/18 (22%)
		C2H2 Zn finger	643..663	CDD:275368	5/10 (50%)
		C2H2 Zn finger	671..691	CDD:275368
		zf-H2C2_2	683..708	CDD:290200
		C2H2 Zn finger	699..719	CDD:275368
		C2H2 Zn finger	755..775	CDD:275368
		zf-H2C2_2	767..789	CDD:290200
		C2H2 Zn finger	783..803	CDD:275368
		zf-H2C2_2	795..820	CDD:290200
		C2H2 Zn finger	811..831	CDD:275368
		zf-H2C2_2	824..848	CDD:290200
		C2H2 Zn finger	839..859	CDD:275368
		zf-H2C2_2	852..876	CDD:290200
		C2H2 Zn finger	867..887	CDD:275368
		C2H2 Zn finger	895..915	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000