DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and Zfp111

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_579857.1	Gene:	Zfp111 / 170849	RGDID:	620595	Length:	744	Species:	Rattus norvegicus

Alignment Length:	741	Identity:	157/741 - (21%)
Similarity:	232/741 - (31%)	Gaps:	221/741 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 QLVSEQFRHHGFNLAAAAAAAQAQFNANG-----QVVGGVVSGSGEPRPPSSSSSGSQRGSVPPA 542
            ||:..:...|..|..|.|..|.......|     |........:.|||.||...|
  Rat    70 QLLYWEITGHDANKLARAPEAVVHTQGKGSHFLEQGHSSCHREAEEPRRPSEDDS---------- 124

  Fly   543 ALPPPSLSSQQQQQQQQAVQQQQQQGAQQ------QLQSAQQQQQSQQQSQQQQQITPGLVGGAG 601
                 ||.|..:........|:...|..|      .|:..|..|:...|:
  Rat   125 -----SLDSLTRDHSSTTENQEFLSGRAQGSWCKTHLRKRQNHQKHCLQT--------------- 169

  Fly   602 GSLKLEPQQMDFYSQRLRQLAGTTSPGAGSTVNSSSPSPRQKQSPHFASPSPSQQ---------- 656
             .:|.:|:                      .:...||..|.::....:|..|.||
  Rat   170 -LMKNKPE----------------------LLTQHSPVQRTQEDSRHSSSVPIQQSVHPGRKRYW 211

  Fly   657 ---------QQQQLATIPRPHSLTPPEKLGDAS---SENGSLGLILASTPRSASTP--------- 700
                     |...|.|..|.|:...|.:  |.|   |.:.|.||.:.....:...|
  Rat   212 CHECGKGFSQSSALQTHRRVHTGEKPCR--DNSCRKSFSRSSGLSIHRQVHTGERPYRCKVCGKG 274

  Fly   701 ------------------PSKTGDV-----------------SLQEPIAHCYSCSYCDKKFRFEN 730
                              |.|.|:.                 |.::|    |.|..|.|.|....
  Rat   275 FLRWSHLQAHERIHTGEKPYKCGECGKRFSCISNLHTHQRFHSKEKP----YKCDKCGKCFSLNF 335

  Fly   731 NLIIHQRTHTGEKPYKCTACDFECSHIQ-KLMKHMRVHRSPADDQDNQDNQDDG---SNADSLET 791
            ||.||||.|||||||||..|. :|..:. .|..|.|||..    :.....::.|   |:|.|.:.
  Rat   336 NLHIHQRVHTGEKPYKCEECG-KCFSLSFNLHSHQRVHTG----EKPYKCEECGKCFSSASSFQR 395

  Fly   792 NEADNDEDPNPDESEEELGDGDNDPDGDGDLDGEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQ 856
            :...:.:       |:.|   ..|..|.|.....:....:....::..|:......|.|......
  Rat   396 HRQIHIK-------EKTL---HRDVCGKGSSRDSNLQTHQRVHIQEKPYRCNSCGKSFRCSMDLN 450

  Fly   857 SPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQ--ALQESGRKEAAAAAAAAAAAADNNNRGGA 919
            ..:...:|......|:..| |. |...:.:|:::  |.|:..:.|......:.::....:.|...
  Rat   451 IHRRVHTGEKPYKCEVCGK-GF-NYLSHLQAHEKIHADQKPYKCEYCGRRFSYSSNLHTHQRVHT 513

  Fly   920 GAPLSDKLNGLPVAALRLRDEF--AKNCNMFQQPQDGGAPSQVPLFNPFPNPFELSKRMKMDGGD 982
            |..        |.........|  |.:....|:.|.|            ..||:.:...|.....
  Rat   514 GEK--------PYKCEECGKSFSLASSLQAHQRVQTG------------KKPFKCNACQKRFSQA 558

  Fly   983 W-WGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKKESRQRNDTCEFCGKVFKNCSNLTVH 1046
            | ....|.:|..|        ||.                       .|:.|||.|...|:|.:|
  Rat   559 WNLQAHQRVHTGE--------KPY-----------------------KCDTCGKAFGQRSSLQIH 592

  Fly  1047 RRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEKHMRKCVVN 1111
            :|.||||||:|||.|....:.:|.||.|.:.|  ||:..|.|..|...||:.|:|..|.|   ::
  Rat   593 QRIHTGEKPFKCEECGKEFSLNSGLTAHRRVH--TGEKPYECTECGKGFSLASSLRTHQR---IH 652

  Fly  1112 QGKAAAAANAVAAAQAAQAAAQHIQA 1137
            .|:.....|   ..|...:...|:|:
  Rat   653 TGEKPFQCN---ECQKRFSQVSHLQS 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	11/21 (52%)
		C2H2 Zn finger	719..739	CDD:275368	10/19 (53%)
		zf-H2C2_2	731..756	CDD:338759	17/24 (71%)
		C2H2 Zn finger	747..767	CDD:275368	6/20 (30%)
		zf-C2H2	1029..1050	CDD:333835	9/20 (45%)
		C2H2 Zn finger	1030..1050	CDD:275368	9/19 (47%)
		zf-H2C2_2	1042..1067	CDD:338759	13/24 (54%)
		C2H2 Zn finger	1058..1078	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1088..1106	CDD:275368	7/17 (41%)
Zfp111	NP_579857.1	KRAB	8..>54	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	<106..396	CDD:227381	74/353 (21%)
		C2H2 Zn finger	212..232	CDD:275368	4/19 (21%)
		C2H2 Zn finger	241..260	CDD:275368	5/18 (28%)
		C2H2 Zn finger	268..288	CDD:275368	0/19 (0%)
		zf-H2C2_2	280..305	CDD:290200	3/24 (13%)
		C2H2 Zn finger	296..316	CDD:275368	1/19 (5%)
		COG5048	306..721	CDD:227381	107/450 (24%)
		C2H2 Zn finger	324..344	CDD:275368	10/19 (53%)
		zf-H2C2_2	340..360	CDD:290200	14/20 (70%)
		C2H2 Zn finger	352..372	CDD:275368	6/20 (30%)
		zf-H2C2_2	367..389	CDD:290200	5/25 (20%)
		C2H2 Zn finger	380..400	CDD:275368	4/19 (21%)
		C2H2 Zn finger	409..428	CDD:275368	3/18 (17%)
		zf-H2C2_2	420..445	CDD:290200	2/24 (8%)
		C2H2 Zn finger	436..456	CDD:275368	2/19 (11%)
		zf-H2C2_2	448..473	CDD:290200	4/26 (15%)
		C2H2 Zn finger	464..484	CDD:275368	5/21 (24%)
		C2H2 Zn finger	492..512	CDD:275368	2/19 (11%)
		zf-H2C2_2	507..528	CDD:290200	3/28 (11%)
		C2H2 Zn finger	520..540	CDD:275368	3/19 (16%)
		C2H2 Zn finger	548..568	CDD:275368	3/19 (16%)
		zf-H2C2_2	560..583	CDD:290200	9/53 (17%)
		C2H2 Zn finger	576..596	CDD:275368	9/19 (47%)
		zf-H2C2_2	588..612	CDD:290200	13/23 (57%)
		C2H2 Zn finger	604..624	CDD:275368	7/19 (37%)
		zf-H2C2_2	617..640	CDD:290200	9/24 (38%)
		C2H2 Zn finger	632..652	CDD:275368	8/22 (36%)
		zf-H2C2_2	644..669	CDD:290200	6/30 (20%)
		C2H2 Zn finger	660..680	CDD:275368	4/19 (21%)
		zf-H2C2_2	672..697	CDD:290200	2/4 (50%)
		C2H2 Zn finger	688..708	CDD:275368
		zf-H2C2_2	701..723	CDD:290200
		C2H2 Zn finger	716..736	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000