DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9650 and ZNF92

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_689839.1	Gene:	ZNF92 / 168374	HGNCID:	13168	Length:	586	Species:	Homo sapiens

Alignment Length:	395	Identity:	91/395 - (23%)
Similarity:	122/395 - (30%)	Gaps:	159/395 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 YSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPADDQDNQDNQD 781
            |.|..|.|.|...:||..|:..|||||||||..|....:....|.||.|:|
Human   229 YKCEECGKAFNRSSNLTKHKIIHTGEKPYKCEECGKAFNRSSTLTKHKRIH-------------- 279

  Fly   782 DGSNADSLETNEADNDEDPNPDESEEELGDGDNDPDGDGDLDGEDEDEDELEECEDMDYKAEDLS 846
                                                          .|::..:||:........|
Human   280 ----------------------------------------------TEEKPYKCEECGKAFNQFS 298

  Fly   847 VSN---RIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQALQESGRKEAAAAAAAAA 908
            :.|   ||..:.:..|....|....|..::.|..:.:..:  :.||  .:|.|:
Human   299 ILNKHKRIHMEDKPYKCEECGKAFRVFSILKKHKIIHTGE--KPYK--CEECGK----------- 348

  Fly   909 AAADNNNRGGAGAPLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNPFPNPFELS 973
                                                                 .||.|.|   |:
Human   349 -----------------------------------------------------AFNQFSN---LT 357

  Fly   974 KRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKKESR----QRNDTCEFCG 1034
            |.            :.:|..|..:   |....|    .:..|...|.|..|    ::...||.||
Human   358 KH------------KIIHTGEKPY---KCDECG----KAFNQSSTLTKHKRIHTGEKPYKCEECG 403

  Fly  1035 KVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPS 1099
            |.||..|.||.|:..||||||||||.|..|.:.||..|:|.:.|  .....|:|..|...|||.|
Human   404 KAFKQSSTLTEHKIIHTGEKPYKCEKCGKAFSWSSAFTKHKRNH--MEDKPYKCEECGKAFSVFS 466

  Fly  1100 TLEKH 1104
            ||.||
Human   467 TLTKH 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	8/21 (38%)
		C2H2 Zn finger	719..739	CDD:275368	7/19 (37%)
		zf-H2C2_2	731..756	CDD:338759	13/24 (54%)
		C2H2 Zn finger	747..767	CDD:275368	6/19 (32%)
		zf-C2H2	1029..1050	CDD:333835	11/20 (55%)
		C2H2 Zn finger	1030..1050	CDD:275368	11/19 (58%)
		zf-H2C2_2	1042..1067	CDD:338759	15/24 (63%)
		C2H2 Zn finger	1058..1078	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1088..1106	CDD:275368	10/17 (59%)
ZNF92	NP_689839.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		zf-H2C2_2	216..240	CDD:290200	5/10 (50%)
		COG5048	227..579	CDD:227381	91/395 (23%)
		C2H2 Zn finger	231..251	CDD:275368	7/19 (37%)
		zf-H2C2_2	243..268	CDD:290200	13/24 (54%)
		C2H2 Zn finger	259..279	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..296	CDD:290200	8/83 (10%)
		C2H2 Zn finger	287..307	CDD:275368	5/19 (26%)
		zf-H2C2_2	300..322	CDD:290200	5/21 (24%)
		C2H2 Zn finger	315..335	CDD:275368	3/19 (16%)
		zf-H2C2_2	328..352	CDD:290200	6/91 (7%)
		C2H2 Zn finger	343..363	CDD:275368	8/98 (8%)
		zf-H2C2_2	355..380	CDD:290200	7/46 (15%)
		C2H2 Zn finger	371..391	CDD:275368	5/23 (22%)
		zf-H2C2_2	384..408	CDD:290200	9/23 (39%)
		C2H2 Zn finger	399..419	CDD:275368	11/19 (58%)
		zf-H2C2_2	412..435	CDD:290200	15/22 (68%)
		C2H2 Zn finger	427..447	CDD:275368	8/19 (42%)
		C2H2 Zn finger	455..475	CDD:275368	10/17 (59%)
		zf-H2C2_2	468..492	CDD:290200	3/4 (75%)
		C2H2 Zn finger	483..503	CDD:275368
		C2H2 Zn finger	539..556	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000