DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and ZNF296

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_660331.1	Gene:	ZNF296 / 162979	HGNCID:	15981	Length:	475	Species:	Homo sapiens

Alignment Length:	669	Identity:	150/669 - (22%)
Similarity:	205/669 - (30%)	Gaps:	297/669 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   532 SGSQRGSVPPAALPPPSLSSQQQQQQQQAVQQQQQQGAQQQLQSAQQQQQSQQQSQQQQQITPGL 596
            |..:.||.|....|.|:.:...:.:.|..|           ::...:.....||:.:....:|..
Human     2 SRRKAGSAPRRVEPAPAANPDDEMEMQDLV-----------IELKPEPDAQPQQAPRLGPFSPKE 55

  Fly   597 VGGAG--GSLKLEPQQMDFYSQRLRQLAGTTSPG---AGSTVNSSSP-------SPRQKQSPHFA 649
            |..||  |.   ||..               |||   ||:.:.:..|       :|   .:|::.
Human    56 VSSAGRFGG---EPHH---------------SPGPMPAGAALLALGPRNPWTLWTP---LTPNYP 99

  Fly   650 SPSPSQQQQQQLATIPRPHSLTPPE---------KLG---------DASSENGSL---------- 686
            ...|...:...|.|..|.....|.|         |||         ...||...|
Human   100 DRQPWTDKHPDLLTCGRCLQTFPLEAITAFMDHKKLGCQLFRGPSRGQGSEREELKALSCLRCGK 164

  Fly   687 ----------------GLILAST------------------------PRSASTPPSKTGD-VSLQ 710
                            ||.:..|                        |.:.:..|..:|. ::.:
Human   165 QFTVAWKLLRHAQWDHGLSIYQTESEAPEAPLLGLAEVAAAVSAVVGPAAEAKSPRASGSGLTRR 229

  Fly   711 EPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHR-----SP 770
            .|     :|..|.|.....:||.:|.|:||||:||.|..|.:.|:...||.:|.:.||     ||
Human   230 SP-----TCPVCKKTLSSFSNLKVHMRSHTGERPYACDQCPYACAQSSKLNRHKKTHRQVPPQSP 289

  Fly   771 ADDQDNQDNQDDGSNADSLETNEADNDEDPNPDESEEELGDGDNDPDGDGDLDGEDEDEDELEEC 835
            .                             ..|.|:|:......:|
Human   290 L-----------------------------MADTSQEQASAAPPEP------------------- 306

  Fly   836 EDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQALQESGRKEA 900
                                                          |.::.|....|..||.:.|
Human   307 ----------------------------------------------AVHAAAPTSTLPCSGGEGA 325

  Fly   901 AAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNP 965
            .|||.|..                                           |:.|||.......|
Human   326 GAAATAGV-------------------------------------------QEPGAPGSGAQAGP 347

  Fly   966 FPNPFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKK------ESR 1024
                          |||.||......|.:.              |||....|  ||      :||
Human   348 --------------GGDTWGAITTEQRTDP--------------ANSQKASP--KKMPKSGGKSR 382

  Fly  1025 QRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRT-GKDVYRC 1088
            ....:||||||.|.|.|||||||||||||:||.||.|:|||||||||.||.:.||.| |...:.|
Human   383 GPGGSCEFCGKHFTNSSNLTVHRRSHTGERPYTCEFCNYACAQSSKLNRHRRMHGMTPGSTRFEC 447

  Fly  1089 RFCDMPFSVPSTLEKHMRK 1107
            ..|.:||.:.:||:||:|:
Human   448 PHCHVPFGLRATLDKHLRQ 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	7/21 (33%)
		C2H2 Zn finger	719..739	CDD:275368	7/19 (37%)
		zf-H2C2_2	731..756	CDD:338759	13/24 (54%)
		C2H2 Zn finger	747..767	CDD:275368	6/19 (32%)
		zf-C2H2	1029..1050	CDD:333835	16/20 (80%)
		C2H2 Zn finger	1030..1050	CDD:275368	16/19 (84%)
		zf-H2C2_2	1042..1067	CDD:338759	20/24 (83%)
		C2H2 Zn finger	1058..1078	CDD:275368	14/19 (74%)
		C2H2 Zn finger	1088..1106	CDD:275368	8/17 (47%)
ZNF296	NP_660331.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78		22/104 (21%)
		zf-C2H2	232..253	CDD:306579	7/20 (35%)
		C2H2 Zn finger	233..253	CDD:275370	7/19 (37%)
		zf-H2C2_2	245..270	CDD:316026	13/24 (54%)
		C2H2 Zn finger	261..281	CDD:275370	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..385		38/276 (14%)
		zf-C2H2_2	387..>467	CDD:315435	50/80 (63%)
		zf-C2H2	387..408	CDD:306579	16/20 (80%)
		C2H2 Zn finger	388..408	CDD:275368	16/19 (84%)
		zf-H2C2_2	400..425	CDD:316026	20/24 (83%)
		C2H2 Zn finger	416..436	CDD:275368	14/19 (74%)
		C2H2 Zn finger	447..465	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45993
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	2.060