Protein Alignment Cph and ZNF296

DIOPT Version :10

• Sequence 1: NP_001356899.1
• Gene: Cph / 31660
• FlyBaseID: FBgn0029939
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_660331.1
• Gene: ZNF296 / 162979
• HGNCID: 15981
• Length: 475
• Species: Homo sapiens
• Alignment Length: 669
• Identity: 150/669 - (22%)
• Similarity: 205/669 - (30%)
• Gaps: 297/669 - (44%)

  Fly   532 SGSQRGSVPPAALPPPSLSSQQQQQQQQAVQQQQQQGAQQQLQSAQQQQQSQQQSQQQQQITPGL 596
            |..:.||.|....|.|:.:...:.:.|..|           ::...:.....||:.:....:|..
Human     2 SRRKAGSAPRRVEPAPAANPDDEMEMQDLV-----------IELKPEPDAQPQQAPRLGPFSPKE 55

  Fly   597 VGGAG--GSLKLEPQQMDFYSQRLRQLAGTTSPG---AGSTVNSSSP-------SPRQKQSPHFA 649
            |..||  |.   ||..               |||   ||:.:.:..|       :|   .:|::.
Human    56 VSSAGRFGG---EPHH---------------SPGPMPAGAALLALGPRNPWTLWTP---LTPNYP 99

  Fly   650 SPSPSQQQQQQLATIPRPHSLTPPE---------KLG---------DASSENGSL---------- 686
            ...|...:...|.|..|.....|.|         |||         ...||...|
Human   100 DRQPWTDKHPDLLTCGRCLQTFPLEAITAFMDHKKLGCQLFRGPSRGQGSEREELKALSCLRCGK 164

  Fly   687 ----------------GLILAST------------------------PRSASTPPSKTGD-VSLQ 710
                            ||.:..|                        |.:.:..|..:|. ::.:
Human   165 QFTVAWKLLRHAQWDHGLSIYQTESEAPEAPLLGLAEVAAAVSAVVGPAAEAKSPRASGSGLTRR 229

  Fly   711 EPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHR-----SP 770
            .|     :|..|.|.....:||.:|.|:||||:||.|..|.:.|:...||.:|.:.||     ||
Human   230 SP-----TCPVCKKTLSSFSNLKVHMRSHTGERPYACDQCPYACAQSSKLNRHKKTHRQVPPQSP 289

  Fly   771 ADDQDNQDNQDDGSNADSLETNEADNDEDPNPDESEEELGDGDNDPDGDGDLDGEDEDEDELEEC 835
            .                             ..|.|:|:......:|
Human   290 L-----------------------------MADTSQEQASAAPPEP------------------- 306

  Fly   836 EDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYKQALQESGRKEA 900
                                                          |.::.|....|..||.:.|
Human   307 ----------------------------------------------AVHAAAPTSTLPCSGGEGA 325

  Fly   901 AAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNP 965
            .|||.|..                                           |:.|||.......|
Human   326 GAAATAGV-------------------------------------------QEPGAPGSGAQAGP 347

  Fly   966 FPNPFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKK------ESR 1024
                          |||.||......|.:.              |||....|  ||      :||
Human   348 --------------GGDTWGAITTEQRTDP--------------ANSQKASP--KKMPKSGGKSR 382

  Fly  1025 QRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRT-GKDVYRC 1088
            ....:||||||.|.|.|||||||||||||:||.||.|:|||||||||.||.:.||.| |...:.|
Human   383 GPGGSCEFCGKHFTNSSNLTVHRRSHTGERPYTCEFCNYACAQSSKLNRHRRMHGMTPGSTRFEC 447

  Fly  1089 RFCDMPFSVPSTLEKHMRK 1107
            ..|.:||.:.:||:||:|:
Human   448 PHCHVPFGLRATLDKHLRQ 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cph	NP_001356899.1	zf-C2H2	717..739	CDD:395048	7/21 (33%)
		C2H2 Zn finger	719..739	CDD:275368	7/19 (37%)
		zf-H2C2_2	731..756	CDD:463886	13/24 (54%)
		C2H2 Zn finger	747..767	CDD:275368	6/19 (32%)
		zf-C2H2	1029..1050	CDD:395048	16/20 (80%)
		C2H2 Zn finger	1030..1050	CDD:275368	16/19 (84%)
		zf-H2C2_2	1042..1067	CDD:463886	20/24 (83%)
		C2H2 Zn finger	1058..1078	CDD:275368	14/19 (74%)
		C2H2 Zn finger	1088..1106	CDD:275368	8/17 (47%)
ZNF296	NP_660331.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..78		22/104 (21%)
		zf-C2H2	232..253	CDD:395048	7/20 (35%)
		C2H2 Zn finger	233..253	CDD:275370	7/19 (37%)
		zf-H2C2_2	245..270	CDD:463886	13/24 (54%)
		C2H2 Zn finger	261..281	CDD:275370	6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	275..385		38/276 (14%)
		zf-C2H2	387..408	CDD:395048	16/20 (80%)
		zf-C2H2_2	388..>467	CDD:463690	50/79 (63%)
		C2H2 Zn finger	388..408	CDD:275368	16/19 (84%)
		zf-H2C2_2	400..425	CDD:463886	20/24 (83%)
		C2H2 Zn finger	416..436	CDD:275368	14/19 (74%)
		C2H2 Zn finger	447..465	CDD:275368	8/17 (47%)