DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9650 and ZNF836

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001096127.1	Gene:	ZNF836 / 162962	HGNCID:	34333	Length:	936	Species:	Homo sapiens

Alignment Length:	508	Identity:	122/508 - (24%)
Similarity:	174/508 - (34%)	Gaps:	107/508 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   656 QQQQQLATIPRPHSLTPPEKLGD-ASSENGSLGLILASTPRSASTP--------PSKTGDVSLQE 711
            :|...|....|.|:...|.|..: ..|.:.|..|.:.....:...|        ..|.|......
Human   284 RQNSDLVNHRRSHTGEKPYKCNECGKSFSQSYNLAIHQRIHTGEKPYKCNECGKTFKQGSCLTTH 348

  Fly   712 PIAHC----YSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPAD 772
            .|.|.    |.|..|.|.||..:||:.|||.|||||||||..|....|....|..|..||
Human   349 QIIHTGEKPYQCDICGKVFRQNSNLVNHQRIHTGEKPYKCNICGKSFSQSSNLATHQTVH----- 408

  Fly   773 DQDNQDNQDDG-----SNADSLETNE-ADNDEDPNPDE-------SEEELGDGDNDPDGDGDLDG 824
             ..|:..:.|.     ..:.||.|:: ....|.|...:       ...:|........|
Human   409 -SGNKPYKCDECGKTFKRSSSLTTHQIIHTGEKPYTCDVCDKVFSQRSQLARHQRSHTG------ 466

  Fly   825 EDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYSEAYK 889
              |...:..||..:..:...|....||....:..|....|.....|.|:.:   ..|....|...
Human   467 --EKPYKCNECGKVFSQTSHLVGHRRIHTGEKPYKCDKCGKAFKQGSLLTR---HKIIHTREKRY 526

  Fly   890 QALQESGRKEAAAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRLR-DEFAKNCNMFQQPQD 953
            |.                         |..|...|:  |...|..||:. .|....||:..:
Human   527 QC-------------------------GECGKVFSE--NSCLVRHLRIHTGEQPYKCNVCGK--- 561

  Fly   954 GGAPSQVPLFNPFPNPFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPL 1018
                    :|| :.....:.||              :|..|..|:   ....|....|.......
Human   562 --------VFN-YSGNLSIHKR--------------IHTGEKPFQ---CNECGTVFRNYSCLARH 600

  Fly  1019 LKKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGK 1083
            |:..:.|:...|..|||||.:..||:.|:|.||||||::|..|....:..|.|.||.|.|  ||:
Human   601 LRIHTGQKPYKCNVCGKVFNDSGNLSNHKRIHTGEKPFQCNECGKVFSYYSCLARHRKIH--TGE 663

  Fly  1084 DVYRCRFCDMPFSVPSTLEKHMRKCVVNQGKAAAAANAVAAA--QAAQAAAQH 1134
            ..|:|..|...::..|:|.||:   :::.|:.....|....|  |:::.|..|
Human   664 KPYKCNDCGKAYTQRSSLTKHL---IIHTGEKPYNCNEFGGAFIQSSKLARYH 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	11/21 (52%)
		C2H2 Zn finger	719..739	CDD:275368	10/19 (53%)
		zf-H2C2_2	731..756	CDD:338759	15/24 (63%)
		C2H2 Zn finger	747..767	CDD:275368	5/19 (26%)
		zf-C2H2	1029..1050	CDD:333835	10/20 (50%)
		C2H2 Zn finger	1030..1050	CDD:275368	10/19 (53%)
		zf-H2C2_2	1042..1067	CDD:338759	12/24 (50%)
		C2H2 Zn finger	1058..1078	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1088..1106	CDD:275368	6/17 (35%)
ZNF836	NP_001096127.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	220..240	CDD:275368
		C2H2 Zn finger	248..268	CDD:275368
		COG5048	272..648	CDD:227381	101/436 (23%)
		C2H2 Zn finger	276..296	CDD:275368	3/11 (27%)
		zf-H2C2_2	288..313	CDD:290200	6/24 (25%)
		C2H2 Zn finger	304..324	CDD:275368	3/19 (16%)
		zf-H2C2_2	316..341	CDD:290200	2/24 (8%)
		C2H2 Zn finger	332..352	CDD:275368	3/19 (16%)
		zf-H2C2_2	345..369	CDD:290200	7/23 (30%)
		C2H2 Zn finger	360..380	CDD:275368	10/19 (53%)
		zf-H2C2_2	372..397	CDD:290200	15/24 (63%)
		C2H2 Zn finger	388..408	CDD:275368	5/19 (26%)
		zf-H2C2_2	400..425	CDD:290200	6/30 (20%)
		C2H2 Zn finger	416..436	CDD:275368	4/19 (21%)
		zf-H2C2_2	428..453	CDD:290200	5/24 (21%)
		C2H2 Zn finger	444..464	CDD:275368	1/19 (5%)
		zf-H2C2_2	457..481	CDD:290200	5/31 (16%)
		C2H2 Zn finger	472..492	CDD:275368	4/19 (21%)
		zf-H2C2_2	484..509	CDD:290200	5/24 (21%)
		COG5048	496..904	CDD:227381	67/282 (24%)
		C2H2 Zn finger	500..520	CDD:275368	4/22 (18%)
		C2H2 Zn finger	528..548	CDD:275368	7/46 (15%)
		zf-H2C2_2	541..565	CDD:290200	8/35 (23%)
		C2H2 Zn finger	556..576	CDD:275368	6/45 (13%)
		zf-H2C2_2	568..593	CDD:290200	6/41 (15%)
		C2H2 Zn finger	584..604	CDD:275368	3/19 (16%)
		zf-H2C2_2	597..620	CDD:290200	7/22 (32%)
		C2H2 Zn finger	612..632	CDD:275368	10/19 (53%)
		zf-H2C2_2	624..649	CDD:290200	12/24 (50%)
		C2H2 Zn finger	640..660	CDD:275368	7/19 (37%)
		zf-H2C2_2	653..677	CDD:290200	10/25 (40%)
		C2H2 Zn finger	668..688	CDD:275368	6/22 (27%)
		C2H2 Zn finger	696..714	CDD:275370	5/18 (28%)
		C2H2 Zn finger	724..744	CDD:275368
		C2H2 Zn finger	752..772	CDD:275368
		zf-H2C2_2	764..789	CDD:290200
		C2H2 Zn finger	780..800	CDD:275368
		zf-H2C2_2	793..815	CDD:290200
		C2H2 Zn finger	808..828	CDD:275368
		zf-H2C2_2	821..843	CDD:290200
		C2H2 Zn finger	836..856	CDD:275368
		zf-H2C2_2	849..873	CDD:290200
		C2H2 Zn finger	864..884	CDD:275368
		zf-H2C2_2	877..899	CDD:290200
		C2H2 Zn finger	892..912	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000