Protein Alignment Cph and hivep2b

DIOPT Version :10

• Sequence 1: NP_001356899.1
• Gene: Cph / 31660
• FlyBaseID: FBgn0029939
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: XP_005158638.1
• Gene: hivep2b / 100536055
• ZFINID: ZDB-GENE-130530-562
• Length: 1798
• Species: Danio rerio
• Alignment Length: 1027
• Identity: 209/1027 - (20%)
• Similarity: 346/1027 - (33%)
• Gaps: 338/1027 - (32%)

  Fly     3 NKMLSISEDHGFRSLSHSDSTENDAVA------------TQDILTCGACQK-----AFALSDIVK 50
            :.:..:|||...:.:| |||..:|...            |..:....:.:|     :..|..|.|
Zfish   569 SNVTGLSEDLETKQIS-SDSVVSDTERKAGSNVISVIQHTNSLNRLNSAEKLSEVRSHQLDKIGK 632

  Fly    51 FIQ----------------------HKVLQCNKENYGQCATQNPQMDRDAEEGRPLSL----VNR 89
            |::                      |:.|..:|:...|...|.|::....|..||..:    |.:
Zfish   633 FMEKGHSMECHRTGSECQWGPCGFLHQKLHMHKQPTSQPNIQVPEIRVTVEPDRPEKVPDVGVKQ 697

  Fly    90 R---------PSISAPISG---RKSAPASAAAAVAAAAAAAAAAAAASSTASGSRIHTPPPSPAD 142
            |         |..|..:|.   .|..|......:|....::..::..|:..|.||    .||...
Zfish   698 REKHTEEFQWPQRSETLSQFPMEKLPPKKKRLRLAEMECSSGESSFESACTSLSR----SPSQDS 758

  Fly   143 LLADGASSTPK-------RLV-----DENDN-----TTPKDSETGATTLDSNAA-------PSSP 183
            .|:..:|.:..       .||     ||:..     :.|..|::....:..:|:       ||..
Zfish   759 NLSHSSSFSQSLDREETLNLVSQINPDESSKPLEFLSVPGSSQSHHREMRRSASEQAPYKLPSEI 823

  Fly   184 AAIERQS------SGDSSCEMEEQQDRQDKQSQPKQAKVKQEPYDEEGVNHHQNQDDDDDEEMEE 242
            |....:|      |..|:..:||.::|: :....:||.:..||         :.|..:..:|:.:
Zfish   824 AEFRSKSFDYGSLSPSSTYRLEEVKERR-RAFLVRQASLSGEP---------ETQGGNFSDEISK 878

  Fly   243 RSLAKRPKMELVDAEANTVHTEPSNYTCSTCKTRYT--SAWRLIQHVQHSHGVKIYVESPGGGAT 305
            |:                  |.|.....|..|.||:  |......|.|:|.     |:|......
Zfish   879 RT------------------TLPFTPEGSIEKMRYSLISGSSFPHHRQYSP-----VQSSSQHVK 920

  Fly   306 LTVATPAALNNSALALAAAAAAASASGLASPQPAVSPNPAVTSSAKR---SSPLGAAGSTILSTS 367
            .||.....:.|..|.:.           ..|:.:.||...|.....:   |..||...|||...|
Zfish   921 PTVCNVHDMENVMLVIK-----------KEPEESKSPETYVNLREPQEDCSQSLGNVLSTIAVLS 974

  Fly   368 -----VSSTCSNSLV--------NTSGGSISNTS---SIGSPQQQQLQ-LQQQQAQQQQQRVQQQ 415
                 ::|.||:.|:        ..|.|:|:.||   .:.|..|:.:. |:.:::..|.|::
Zfish   975 QAQQALASQCSSGLLVPVRIQMQVPSYGNITYTSISHILDSHIQKPISCLEHKKSSSQSQQL--- 1036

  Fly   416 QRENLASAMAAGMRHHPLLPPPEAMHANPFQLLRMPLPPALAQAGNVVPTVAPLFGRP----SPA 476
                                  .::.|:|.: |:..:|.:|. :..:..|.||..|..    |||
Zfish  1037 ----------------------HSLQASPAK-LKTGIPLSLT-SKTISTTEAPSGGANKRMLSPA 1077

  Fly   477 DHYRMEQLVSEQFRHHGFNLAAAAAAAQAQFNANGQVVGGVVSGSGEPRPPSSSSSGSQRGSVPP 541
            ....:.....:|.|....|:             .||:|              ...|..:.|::..
Zfish  1078 SSIELFIEAKQQKRVKDENI-------------YGQIV--------------EELSAVELGNLEV 1115

  Fly   542 AALPPPSLSSQQQQQQQQAVQQQQQQGAQQQLQSAQQQQQSQQQSQ----QQQQITPGLVGGAGG 602
            ....|.|      :...:.:.:.....|.|:..|..:.|.|.:.||    .:|:.||..:..:..
Zfish  1116 EKESPKS------EFTSEPIDKMDMDEATQEFYSNAELQSSARISQDAAIMEQKPTPESMMASHH 1174

  Fly   603 S---LKLEPQQMDFYSQRLRQLAGT----TSPGAGST-------VNSSSPSPRQKQSP--HFAS- 650
            |   :.|.|.          .:.||    ..||..:|       :|::.|:.....:|  .:||
Zfish  1175 SASCISLMPS----------AITGTLLFSKFPGLHTTTCMSWCYLNTTKPNSTHTVAPFSEYASW 1229

  Fly   651 ------PSP-------------SQQQQQQ----LATIPRPHSL------TPPE------------ 674
                  |:|             |:||:|.    :|||.:|..|      ||.:
Zfish  1230 FVRCHNPNPPDISTGMVLALLRSKQQRQNAIYTIATIYQPGLLVTSTPWTPKQEQIALDYREEDT 1294

  Fly   675 ----KLGDASSENGSLGLILASTPRSASTPPSKT----GDVSLQEPIAHC-------YSCSYCDK 724
                :|.:.|....||...::|..|  .|.|.:.    |.....|...:.       |.|..|..
Zfish  1295 KQDIRLREISHRGKSLREDVSSIIR--QTEPMRVKIFEGGYKSNEEYVYVRGRGRGKYICEECGI 1357

  Fly   725 KFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHM--RVHR--------SPADDQDNQDN 779
            :.:..:.|..|.||||..:||.|..|:|.......|.|||  :.|.        ||. ..||.::
Zfish  1358 RCKKPSMLRKHIRTHTDVRPYICKCCNFAFKTKGNLTKHMKSKAHMKKCLELGVSPT-AMDNTED 1421

  Fly   780 QDDGSN---------------ADSLETNEADNDEDPNPDESEEELGDGDNDP 816
            .||...               :|..:::.||.||   |||.|::..|||:.|
Zfish  1422 ADDTQKSLGIMPAEQTIKHQFSDVEDSDGADEDE---PDEDEDDECDGDSTP 1470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cph	NP_001356899.1	zf-C2H2	717..739	CDD:395048	6/21 (29%)
		C2H2 Zn finger	719..739	CDD:275368	5/19 (26%)
		zf-H2C2_2	731..756	CDD:463886	11/24 (46%)
		C2H2 Zn finger	747..767	CDD:275368	7/21 (33%)
		zf-C2H2	1029..1050	CDD:395048
		C2H2 Zn finger	1030..1050	CDD:275368
		zf-H2C2_2	1042..1067	CDD:463886
		C2H2 Zn finger	1058..1078	CDD:275368
		C2H2 Zn finger	1088..1106	CDD:275368
hivep2b	XP_005158638.1	zf-C2H2	120..142	CDD:395048
		C2H2 Zn finger	122..142	CDD:275368
		zf-H2C2_2	135..159	CDD:463886
		C2H2 Zn finger	150..170	CDD:275368
		zf-C2H2	1350..1372	CDD:395048	6/21 (29%)
		C2H2 Zn finger	1352..1372	CDD:275370	5/19 (26%)
		C2H2 Zn finger	1380..1398	CDD:275370	6/17 (35%)