DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and bcl11b

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_004917173.1	Gene:	bcl11b / 100486647	XenbaseID:	XB-GENE-993642	Length:	829	Species:	Xenopus tropicalis

Alignment Length:	1202	Identity:	298/1202 - (24%)
Similarity:	415/1202 - (34%)	Gaps:	516/1202 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EDHGFRSLSHSDSTE------------NDAVATQDILTCGACQKAFALSDIVKFIQHKVLQCNKE 62
            |||...::. :|..|            |::....|:||||.||..|.|.||:.||:||..||:..
Frog    21 EDHHVETVI-TDEEEAIAIPEPGAISLNNSGTDPDLLTCGQCQMNFRLGDILVFIEHKKKQCSGP 84

  Fly    63 NYGQCATQNPQMDRDAEEGRPLSLVNRRPSISAPISGRKSAPASAAAAVAAAAAAAAAAAAASST 127
            : |.|  ...:||:.
Frog    85 S-GVC--YEKRMDKS-------------------------------------------------- 96

  Fly   128 ASGSRIHTPPPSP-------ADLLADGASSTPKRLVDENDN-TTPKDSETGATTLDSNAAPSSPA 184
                   :||||.       |:.:..|...||    ||.|. .||
Frog    97 -------SPPPSTRSELRKVAEPVEIGIQVTP----DEEDRLLTP-------------------- 130

  Fly   185 AIERQSSGDSSCEMEEQQDRQDKQSQPKQAKVKQ---------EPYDEEGVNHHQNQDDDDDEEM 240
                                 .|...|||..:.:         :.:.:....|.|::|
Frog   131 ---------------------TKGICPKQENIAEFFSRPVRVIQAHMQAVAPHEQSKD------- 167

  Fly   241 EERSLAKRPKMELVDAEANTVHTEPSNYTCSTCKTRYTSAWRLIQHVQHSHGVKIYVESPGGGAT 305
                                   |||:|.|:|||..:.|||.|:||.|::||.:||:|:.....:
Frog   168 -----------------------EPSSYICTTCKQPFNSAWFLLQHAQNTHGFRIYLETSPSSNS 209

  Fly   306 LTVATPAALNNSALALAAAAAAASASGLASPQPAVSPNPAVTSSAKRSSPLGAAGSTILSTSVSS 370
            ||                            |:..:.|            |||.      .|...|
Frog   210 LT----------------------------PRITIPP------------PLGP------ETVAPS 228

  Fly   371 TCSNSLVNTSGGSISNTSSIGSPQQQQLQLQQQQAQQQQQRVQQQQRENLASAMAAGMRHHPLLP 435
            ...|.|.:|
Frog   229 PLMNFLGDT-------------------------------------------------------- 237

  Fly   436 PPEAMHANPFQLLRMPLP-----PALAQAGNVVPTVAPLFGRPSPADHYRMEQLVSEQFRHHGFN 495
                   |||.||||..|     |...:|.  :|...|||..|.               |||
Frog   238 -------NPFNLLRMTGPILRDHPGFGEAR--LPNTPPLFSPPP---------------RHH--- 275

  Fly   496 LAAAAAAAQAQFNANGQVVGGVVSGSGEPRPPSSSSSGSQRGSVPPAALPPPSLSSQQQQQQQQA 560
                                                            |.|..||:
Frog   276 ------------------------------------------------LDPHRLSA--------- 283

  Fly   561 VQQQQQQGAQQQLQSAQQQQQSQQQSQQQQQITPGLVGGAGGSLKLEPQQMDFYSQRLRQLAGTT 625
                ::.|...|..||         ..:..::.|         :.:|...||| |:|||:|||
Frog   284 ----EEMGLVAQHPSA---------FDRVMRLNP---------MTIESPAMDF-SRRLRELAG-- 323

  Fly   626 SPGAGSTVNSSSPSPRQKQSPHFASP-----SPSQQQQQQLATIPRPHS---LTPPEKLGDASSE 682
                    |:|:|.|   .||:..:|     :|.|         |.|.|   .|||
Frog   324 --------NNSTPPP---VSPNRGNPMHRLLNPFQ---------PSPKSPFISTPP--------- 359

  Fly   683 NGSLGLILASTPRSASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKC 747
                   |...|.|::|||         :..|...||.:|.|.|:|::|||:|:|:|||||||||
Frog   360 -------LPPMPPSSTTPP---------QTQAKSKSCEFCGKTFKFQSNLIVHRRSHTGEKPYKC 408

  Fly   748 TACDFECSHIQKLMKHMRVHRSPADDQDNQDNQDDGSNADS-------------LETNEAD--ND 797
            ..||..||...||.:||:.|...|.....:  .|||.:|.|             ::::|.|  |:
Frog   409 QLCDHACSQASKLKRHMKTHMHKAGSMTGR--SDDGLSATSSPEPGTSDLTGEGVKSSETDFRNE 471

  Fly   798 EDPNPDESEEELGDGDNDPDGDGDLDGEDEDEDELEECEDMDYKAEDLSVSNRID-GKSQSPKTT 861
            .||:.....||              :.|:|:|:|.||.|:........|:.:.:. .:....|..
Frog   472 SDPSLGHENEE--------------EEEEEEEEEEEEIENESRPESSFSMDSEMSRNRENGAKPI 522

  Fly   862 SSGATSLVGELMDKFGLSNIAQYSEAYKQALQES----------------GRKEAAAAAAAAAAA 910
            ....:.::|::|:...|..:..||:...:..:.|                |.::...........
Frog   523 HDEKSLVLGKVMENVHLGGMQAYSDMLHEKQKRSHFMKRSDQQILCRRIPGHEDTVEREIIPNDE 587

  Fly   911 ADNNNRGGAGAPLSDKL---------NGLPVAALRLRDE---------FAKNCNMFQQPQDGGAP 957
            ...|...|.|.|....|         :||..::.|::.|         ...:.|::.|...|.|.
Frog   588 GTVNGNFGPGEPFPGLLPRKPMPISSSGLNNSSKRIKIEKDLDLPPTPIIPSENVYSQWLVGYAA 652

  Fly   958 SQVPLFNPF-------PNPFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKP-LGLGGANSLI 1014
            |:..:.:||       .:||..|.....:.|   .:..:....:.|...|..:. ...||:...|
Frog   653 SRHFMKDPFLGFTDSRQSPFATSSEHSSENG---SLRFSTPPGDMLDGGLSGRSGTASGGSTPHI 714

  Fly  1015 QGP----LLKKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHM 1075
            .||    ...||.| |:||||||||||||||||||||||||||:|||||||:|||||||||||||
Frog   715 SGPGPGRPSSKEGR-RSDTCEFCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHM 778

  Fly  1076 KTHGRTGKDVYRCRFCDMPFSVPSTLEKHMRK 1107
            ||||:.||:||||..|.|||||.|||||||:|
Frog   779 KTHGQIGKEVYRCDICQMPFSVYSTLEKHMKK 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	11/21 (52%)
		C2H2 Zn finger	719..739	CDD:275368	10/19 (53%)
		zf-H2C2_2	731..756	CDD:338759	17/24 (71%)
		C2H2 Zn finger	747..767	CDD:275368	9/19 (47%)
		zf-C2H2	1029..1050	CDD:333835	20/20 (100%)
		C2H2 Zn finger	1030..1050	CDD:275368	19/19 (100%)
		zf-H2C2_2	1042..1067	CDD:338759	22/24 (92%)
		C2H2 Zn finger	1058..1078	CDD:275368	18/19 (95%)
		C2H2 Zn finger	1088..1106	CDD:275368	13/17 (76%)
bcl11b	XP_004917173.1	zf-C2H2	379..400	CDD:333835	11/20 (55%)
		C2H2 Zn finger	380..400	CDD:275368	10/19 (53%)
		zf-H2C2_2	392..417	CDD:372612	17/24 (71%)
		C2H2 Zn finger	408..428	CDD:275368	9/19 (47%)
		zf-C2H2	732..753	CDD:333835	20/20 (100%)
		C2H2 Zn finger	733..753	CDD:275368	19/19 (100%)
		zf-H2C2_2	745..770	CDD:372612	22/24 (92%)
		C2H2 Zn finger	761..781	CDD:275368	18/19 (95%)
		C2H2 Zn finger	791..809	CDD:275368	13/17 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	150	1.000	Domainoid score	I4358
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2107
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D121311at33208
OrthoFinder	1	1.000	-	-		FOG0002010
OrthoInspector	1	1.000	-	-		otm49106
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1492
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060