DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9650 and bcl11bb

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_002667906.3	Gene:	bcl11bb / 100330974	ZFINID:	ZDB-GENE-110201-2	Length:	794	Species:	Danio rerio

Alignment Length:	1176	Identity:	302/1176 - (25%)
Similarity:	409/1176 - (34%)	Gaps:	506/1176 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DHGFRSLSHSDSTENDA--VATQDILTCGACQKAFALSDIVKFIQHKVLQCNKENYGQCATQNPQ 73
            |.|........|..:.|  ....|:||||.||..|.|.||:.||:||...|
Zfish    27 DAGMNQCPSEGSVSSPAGGAGESDLLTCGQCQTNFPLGDILVFIEHKRRLC-------------- 77

  Fly    74 MDRDAEEGRPLSLVNRRPSISAPISGRKSAPASAAAAVAAAAAAAAAAAAASSTASGSRIHTPPP 138
                                                                          |.|
Zfish    78 --------------------------------------------------------------PGP 80

  Fly   139 S-----PADLLADGASSTPKRLVDENDNTTPKDSETGATTLDSNAAPSSPAAIERQSSGDSSCEM 198
            |     |:|.   |.|.:|          :|:              |..|....|
Zfish    81 SSCFDKPSDC---GGSGSP----------SPR--------------PLRPDVCRR---------- 108

  Fly   199 EEQQDRQDKQSQPKQAKVKQEPYDEEGVNHHQNQDDDDDEEMEERSLAKR---PKMELVDAEANT 260
                      |.|.:..::..|.:||                |:|....|   ||.|.|.    |
Zfish   109 ----------SGPVEVGIQVSPREEE----------------EKRLTPARGICPKQEGVP----T 143

  Fly   261 VHTEPSNYTCSTCKTRYTSAWRLIQHVQHSHGVKIYVESPGGGATLTVATPAALNNSALALAAAA 325
            ...|||:|.|:|||..:||||.|:||.|::||::||:::.....:||
Zfish   144 GKDEPSSYICTTCKQPFTSAWFLLQHAQNTHGIRIYLDTHPTSCSLT------------------ 190

  Fly   326 AAASASGLASPQPAVSPNPAVTSSAKRSSPLGAAGSTILSTSVSSTCSNSLVNTSGGSISNTSSI 390
                      |:.|:.|            ||||
Zfish   191 ----------PRMALPP------------PLGA-------------------------------- 201

  Fly   391 GSPQQQQLQLQQQQAQQQQQRVQQQQRENLASAMAAGMRHHPLLPPPEAMHANPFQLLRMPLPPA 455
                                  ....|..|||.:..|              :||||||||.
Zfish   202 ----------------------DALPRSPLASFLGDG--------------SNPFQLLRMG---- 226

  Fly   456 LAQAGNVVPTVAPLFGRPSPADHYRMEQLVSEQFRHHGFNLAAAAAAAQAQFNANGQVVGGVVSG 520
                       |||...|.                 ||:.
Zfish   227 -----------APLLREPP-----------------HGYI------------------------- 238

  Fly   521 SGEPRPPSSSSSGSQRGSVPPAALPPPSLSSQQQQQQQQAVQQQQQQGAQQQLQSAQQQQQSQQQ 585
              |.|.||:          ||...|||.....::       ...::.|...|..||
Zfish   239 --ETRLPST----------PPFVSPPPPRHPLER-------LGPEEMGLLSQHPSA--------- 275

  Fly   586 SQQQQQITPGLVGGAGGSLKLEPQQMDFYSQRLRQLAGTTSPGAGSTVNSSSPSPRQKQSPHFAS 650
            .::..::||         :.:....|.| |||||:|||..        |:..|:|
Zfish   276 FERVMRMTP---------MGIHEPSMGF-SQRLRELAGNN--------NNGGPTP---------- 312

  Fly   651 P-SPSQQQQQQLATIPRPHSLTPPEKLGDASSENGSLGLILASTPRSASTPPSKTGDVSLQEPIA 714
            | ||::        :|..|.|..|...     ::||..|....||....:.||:....|....:.
Zfish   313 PLSPNR--------VPPMHRLLSPTLF-----QHGSKALPFLPTPSQPPSIPSRGNSSSPLNQVG 364

  Fly   715 HCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVH--------RSPA 771
            ...||.:|.|.|:|::|||:|:|:||||:||||..||..||...||.:||:.|        .||
Zfish   365 KAKSCEFCGKTFKFQSNLIVHRRSHTGERPYKCHLCDHACSQASKLKRHMKTHMHKSGSMGSSP- 428

  Fly   772 DDQDNQDNQ-------DDGSNADSLETNEADNDEDPNPDESEEELGDGDNDPDGDGDLDGEDEDE 829
             :|..||:.       :|....:.::..|.::||:...:|.|||.....:.||.:..:|.|
Zfish   429 -EQGGQDSAGEGLKSCEDNGTREGIDNEEEEDDEEEEEEEEEEEEQQNGSRPDSNLSMDSE---- 488

  Fly   830 DELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSG---ATSLVGELMDKFGLSNIAQYSEAYKQA 891
                           || .||.:|    |:||...   ||..|.|          :||:......
Zfish   489 ---------------LS-RNRENG----PRTTPEDKPLATDRVTE----------SQYNNLDNHL 523

  Fly   892 LQESGRKEAAAAAAAAAAAADNNNR----GGAGAPLSDKLNG------LPVAALRLRDEFAKNC- 945
            ....|.:........:.|...:.:|    .|.|....|.::.      :|:::..|....||..
Zfish   524 RLPPGSRPCEGMDRDSQAREIDRDRQPMVNGRGCGPEDSISAMFHRKPMPISSSSLSGSSAKRIK 588

  Fly   946 ----------------NMFQQPQDGGAPS----QVPL--FN-----PFPNPFELSKRMK------ 977
                            |::.|...|.|.|    :.|.  ||     ||..|.|.|....
Zfish   589 VEKDVELPQVPVISPENVYSQLLAGYAASRHFIREPFLGFNDSRQSPFGTPSEHSSSETGSLRFS 653

  Fly   978 ------MDGGDWWGMSQALHRNEALFENLKLKPLGLGGANSLIQGPLLKKESRQRNDTCEFCGKV 1036
                  ::||   |||   .|:::...:|.|:..|.|       .|...|||| |:||||:||||
Zfish   654 TPPGEILEGG---GMS---GRSDSSTPHLHLRGPGPG-------RPPSSKESR-RSDTCEYCGKV 704

  Fly  1037 FKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTL 1101
            |||||||||||||||||:||||:||||||||||||||||||||:.||:||||..|.|||||.|||
Zfish   705 FKNCSNLTVHRRSHTGERPYKCDLCSYACAQSSKLTRHMKTHGQFGKEVYRCDICHMPFSVYSTL 769

  Fly  1102 EKHMRK 1107
            |||::|
Zfish   770 EKHVKK 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	11/21 (52%)
		C2H2 Zn finger	719..739	CDD:275368	10/19 (53%)
		zf-H2C2_2	731..756	CDD:338759	16/24 (67%)
		C2H2 Zn finger	747..767	CDD:275368	9/19 (47%)
		zf-C2H2	1029..1050	CDD:333835	19/20 (95%)
		C2H2 Zn finger	1030..1050	CDD:275368	18/19 (95%)
		zf-H2C2_2	1042..1067	CDD:338759	22/24 (92%)
		C2H2 Zn finger	1058..1078	CDD:275368	18/19 (95%)
		C2H2 Zn finger	1088..1106	CDD:275368	13/17 (76%)
bcl11bb	XP_002667906.3	zf-C2H2	368..389	CDD:278523	11/20 (55%)
		C2H2 Zn finger	369..389	CDD:275368	10/19 (53%)
		zf-H2C2_2	381..406	CDD:290200	16/24 (67%)
		C2H2 Zn finger	397..417	CDD:275368	9/19 (47%)
		zf-C2H2	697..718	CDD:278523	19/20 (95%)
		C2H2 Zn finger	698..718	CDD:275368	18/19 (95%)
		zf-H2C2_2	710..735	CDD:290200	22/24 (92%)
		C2H2 Zn finger	726..746	CDD:275368	18/19 (95%)
		C2H2 Zn finger	756..774	CDD:275368	13/17 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579967
Domainoid	1	1.000	146	1.000	Domainoid score	I4481
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2152
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D121311at33208
OrthoFinder	1	1.000	-	-		FOG0002010
OrthoInspector	1	1.000	-	-		otm25193
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45993
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1492
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.090