DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9650 and ZNF729

DIOPT Version :9

Sequence 1:	NP_001356899.1	Gene:	CG9650 / 31660	FlyBaseID:	FBgn0029939	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001229609.1	Gene:	ZNF729 / 100287226	HGNCID:	32464	Length:	1252	Species:	Homo sapiens

Alignment Length:	501	Identity:	108/501 - (21%)
Similarity:	166/501 - (33%)	Gaps:	161/501 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   630 GSTVNSSSPSPRQKQSPHFASPSPSQQQQQQLATIPRPHSLTPPEKLGDASSENGSLGLILASTP 694
            |.|.|            ||:    :.::.:.:.|..:|:.   .|:.|.|.|::.:|
Human   326 GKTFN------------HFS----ALRKHKIIHTGKKPYK---REECGKAFSQSSTL-------- 363

  Fly   695 RSASTPPSKTGDVSLQEPIAHC----YSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECS 755
                          .:..|.|.    |.|..|.|.|::.:.|.:|:..|||||||||..|....|
Human   364 --------------RKHEIIHTGEKPYKCEECGKAFKWSSKLTVHKVVHTGEKPYKCEECGKAFS 414

  Fly   756 HIQKLMKHMRVHRSPADDQDNQDNQDDGSNADSLETNEADNDEDPNPDESEEELGDGDNDPDGDG 820
            ....|.||..:|......:..:..:...|::..::.......|.|
Human   415 QFSTLKKHKIIHTGKKPYKCEECGKAFNSSSTLMKHKIIHTGEKP-------------------- 459

  Fly   821 DLDGEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVGELMDKFGLSNIAQYS 885
                               ||.|:...:.|........|...:|......|...|    ....:|
Human   460 -------------------YKCEECGKAFRQSSHLTRHKAIHTGEKPYKCEECGK----AFNHFS 501

  Fly   886 EAYKQALQESGRK----EAAAAAAAAAAAADNNNRGGAGAPLSDKLNGLPVAALRLRDEFAKNCN 946
            :..:..:..:|:|    |....|.:.::...|:
Human   502 DLRRHKIIHTGKKPYKCEECGKAFSQSSTLRNH-------------------------------- 534

  Fly   947 MFQQPQDGGAPSQVPLFNPFPNPFELSKRMKMDGGDWWG----MSQALHRNEALFENLKLKPLGL 1007
              |....|..|.:..         |..|..|      |.    :.:.:|..|   :..|.:..|
Human   535 --QIIHTGEKPYKCE---------ECGKAFK------WSSKLTVHKVIHTGE---KPCKCEECG- 578

  Fly  1008 GGANSLIQGPLLKK----ESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQS 1068
               .:......|:|    .:|::...||.|||.|.|.|.|..|:..|||:||||||.|..|..||
Human   579 ---KAFKHFSALRKHKVIHTREKLYKCEECGKAFNNSSILAKHKIIHTGKKPYKCEECGKAFRQS 640

  Fly  1069 SKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEKHMRKCVVNQGK 1114
            |.||||...|  ||:..|:|..|...||..|.|.:|.   :::.||
Human   641 SHLTRHKAIH--TGEKPYKCEECGKAFSHFSALRRHK---IIHTGK 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9650	NP_001356899.1	zf-C2H2	717..739	CDD:333835	7/21 (33%)
		C2H2 Zn finger	719..739	CDD:275368	6/19 (32%)
		zf-H2C2_2	731..756	CDD:338759	12/24 (50%)
		C2H2 Zn finger	747..767	CDD:275368	6/19 (32%)
		zf-C2H2	1029..1050	CDD:333835	10/20 (50%)
		C2H2 Zn finger	1030..1050	CDD:275368	10/19 (53%)
		zf-H2C2_2	1042..1067	CDD:338759	13/24 (54%)
		C2H2 Zn finger	1058..1078	CDD:275368	11/19 (58%)
		C2H2 Zn finger	1088..1106	CDD:275368	7/17 (41%)
ZNF729	NP_001229609.1	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	182..202	CDD:275368
		C2H2 Zn finger	210..230	CDD:275368
		C2H2 Zn finger	239..258	CDD:275368
		COG5048	262..666	CDD:227381	101/481 (21%)
		C2H2 Zn finger	266..286	CDD:275368
		C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	322..342	CDD:275368	5/31 (16%)
		C2H2 Zn finger	351..370	CDD:275368	6/40 (15%)
		zf-H2C2_2	363..386	CDD:290200	7/44 (16%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		C2H2 Zn finger	434..454	CDD:275368	1/19 (5%)
		C2H2 Zn finger	462..482	CDD:275368	3/19 (16%)
		zf-H2C2_2	474..499	CDD:290200	4/28 (14%)
		C2H2 Zn finger	490..510	CDD:275368	3/23 (13%)
		zf-H2C2_2	502..527	CDD:290200	4/24 (17%)
		C2H2 Zn finger	518..538	CDD:275368	4/53 (8%)
		zf-H2C2_2	531..554	CDD:290200	6/65 (9%)
		C2H2 Zn finger	546..566	CDD:275368	4/34 (12%)
		C2H2 Zn finger	574..594	CDD:275368	3/23 (13%)
		C2H2 Zn finger	602..622	CDD:275368	10/19 (53%)
		COG5048	625..1123	CDD:227381	28/62 (45%)
		C2H2 Zn finger	630..650	CDD:275368	11/19 (58%)
		zf-H2C2_2	642..667	CDD:290200	11/26 (42%)
		C2H2 Zn finger	658..678	CDD:275368	7/22 (32%)
		zf-H2C2_2	670..695	CDD:290200	4/15 (27%)
		C2H2 Zn finger	686..706	CDD:275368
		zf-H2C2_2	698..722	CDD:290200
		C2H2 Zn finger	714..734	CDD:275368
		C2H2 Zn finger	742..762	CDD:275368
		C2H2 Zn finger	770..790	CDD:275368
		C2H2 Zn finger	798..818	CDD:275368
		C2H2 Zn finger	826..846	CDD:275368
		C2H2 Zn finger	854..874	CDD:275368
		zf-H2C2_2	866..890	CDD:290200
		C2H2 Zn finger	882..902	CDD:275368
		C2H2 Zn finger	910..930	CDD:275368
		C2H2 Zn finger	938..958	CDD:275368
		C2H2 Zn finger	966..986	CDD:275368
		zf-H2C2_2	978..1003	CDD:290200
		C2H2 Zn finger	994..1014	CDD:275368
		C2H2 Zn finger	1022..1042	CDD:275368
		zf-H2C2_2	1034..1058	CDD:290200
		C2H2 Zn finger	1050..1070	CDD:275368
		C2H2 Zn finger	1078..1098	CDD:275368
		C2H2 Zn finger	1106..1126	CDD:275368
		C2H2 Zn finger	1134..1154	CDD:275368
		C2H2 Zn finger	1162..1182	CDD:275368
		C2H2 Zn finger	1190..1210	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000