Protein Alignment fz4 and Fzd10

DIOPT Version :10

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_780493.1
• Gene: Fzd10 / 93897
• MGIID: 2136761
• Length: 582
• Species: Mus musculus
• Alignment Length: 590
• Identity: 172/590 - (29%)
• Similarity: 265/590 - (44%)
• Gaps: 100/590 - (16%)

  Fly    29 SASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSS 93
            |.::.||...|.|...:|:.:.|.||:.||||.|.||||:|:|.|.:....|..||||:||.|.|
Mouse    18 SCTAISSMDLERPGDGKCQPVEIPMCKDIGYNTTRMPNLMGHENQREAAIQLHEFAPLVEYGCHS 82

  Fly    94 QLKLFLCAAYVPMCTPK--APVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNH 156
            .|:.|||:.|.||||.:  .|:.|   ||.:||..|::|.|:::.|.|.||.:|||.|.|.:|:.
Mouse    83 HLRFFLCSLYAPMCTEQVSTPIPA---CRVMCEQARLKCSPIMEQFKFRWPDSLDCSKLPNKNDP 144

  Fly   157 ETMCMEGPGE--------------LHQPQQEQDLYGLP-GQGIPGGLGGKLPMDCSGLAKSHLYV 206
            ..:|||.|..              |.:||:.......| ..|.||..|      |....|.|
Mouse   145 NYLCMEAPNNGSDEPSRGSGMFPPLFRPQRPHSAQEHPLKDGGPGRAG------CDNPGKFH--- 200

  Fly   207 RLPRSGRCAPLCE--ADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSR 269
            .:.:|..|||||.  .|:.::..:|..|.:|::.|:.... .:...||.....|.||....:
Mouse   201 HVEKSESCAPLCTPGVDVYWSRDDKRFAVVWLAIWSVLCF-FSSAFTVLTFLIDPSRFRYPE--- 261

  Fly   270 LLSPLIW---CHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFG 331
              .|:|:   |:.:.::|:.:|...|....||..|   ..:..:..:||.:..|..|||:.||||
Mouse   262 --RPIIFLSMCYCVYSVGYIIRLFAGAESIACDRD---SGQLYVIQEGLESTGCTLVFLVLYYFG 321

  Fly   332 MAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGL 396
            ||:..||.||.|.|.....:    ..||..|.:|                    :::....||.:
Mouse   322 MASSLWWVVLTLTWFLAAGK----KWGHEAIEAN--------------------SSYFHLAAWAI 362

  Fly   397 PAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEI 461
            ||.:|..::|.|.|..|||.|.|:||:....||...|..|:.||.:.|:..::||::.....:.:
Mouse   363 PAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLVPLACYLVIGTSFILSGFVALFHIRRV 427

  Fly   462 LRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVW---------LGSG 517
            ::.....:  .:|::|...    ||:|..:|.:....::....||..|:|.|         ..:.
Mouse   428 MKTGGENT--DKLEKLMVR----IGVFSLLYTVPATCVIACYFYERLNMDYWKMLATQHKCKMNN 486

  Fly   518 DTNTP----------LWPFLLRAFMELMLGICCFAWVLGPSISTLYKRQVSNGKMVKH------- 565
            .|.||          :..|:::..|.|::||....||........::...|.|...|.
Mouse   487 QTKTPDCLMTTSIPAVEVFMVKVSMLLVVGITSGVWVWTSKTLQSWQHVCSRGLKRKSRRKPASV 551

  Fly   566 -TSAG 569
             ||||
Mouse   552 VTSAG 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	58/141 (41%)
		7tmF_Frizzled_SMO	222..557	CDD:320089	85/356 (24%)
		TM helix 1	231..256	CDD:320089	5/24 (21%)
		TM helix 2	268..289	CDD:320089	4/23 (17%)
		TM helix 3	321..347	CDD:320089	15/25 (60%)
		TM helix 4	388..404	CDD:320089	5/15 (33%)
		TM helix 5	426..455	CDD:320089	9/28 (32%)
		TM helix 6	481..508	CDD:320089	6/26 (23%)
		TM helix 7	519..544	CDD:320089	8/34 (24%)
Fzd10	NP_780493.1	CRD_FZ	31..157	CDD:470581	57/128 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..189		5/35 (14%)
		7tmF_FZD10	218..537	CDD:320165	85/357 (24%)
		TM helix 1	227..252	CDD:320165	5/25 (20%)
		TM helix 2	261..282	CDD:320165	4/25 (16%)
		TM helix 3	311..337	CDD:320165	15/25 (60%)
		TM helix 4	354..370	CDD:320165	5/15 (33%)
		TM helix 5	392..421	CDD:320165	9/28 (32%)
		TM helix 6	441..468	CDD:320165	7/30 (23%)
		TM helix 7	498..523	CDD:320165	5/24 (21%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	527..532		0/4 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	561..582
		PDZ-binding	580..582