Protein Alignment fz4 and FZD9

DIOPT Version :10

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_003499.1
• Gene: FZD9 / 8326
• HGNCID: 4047
• Length: 591
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 178/615 - (28%)
• Similarity: 274/615 - (44%)
• Gaps: 132/615 - (21%)

  Fly    46 CETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPK 110
            |:.:.|.|||.||||.|.||||:|:..|.:....|..||||::|.|.|.|:.|||:.|.||||.:
Human    39 CQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQ 103

  Fly   111 --APVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCME-------GPGE 166
              .|:.|   ||.:||..|:||.|:::.|.|.||.:|||.:.|..|:...:|||       ||.|
Human   104 VSTPIPA---CRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPAE 165

  Fly   167 LHQ--------PQQEQDLYGLPGQGIPGGLGGKLPMDCSGLAKS---HLYVRLPRSGRCAPLC-- 218
            .|:        |:..:.    ||...||. ||      ||..::   ..||...||  |||.|
Human   166 PHKGLGMLPVAPRPARP----PGDLGPGA-GG------SGTCENPEKFQYVEKSRS--CAPRCGP 217

  Fly   219 EADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSP---------- 273
            ..::.::..:|..|.:|::.|          :.:|..::     |....:.||.|
Human   218 GVEVFWSRRDKDFALVWMAVW----------SALCFFST-----AFTVLTFLLEPHRFQYPERPI 267

  Fly   274 --LIWCHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTV-DGLSNASCASVFLMRYYFGMAAC 335
              |..|:|:.:|.:.:|.:.|....||..:..|    |..: :||.|..|..|||:.||||||:.
Human   268 IFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGA----LYVIQEGLENTGCTLVFLLLYYFGMASS 328

  Fly   336 AWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQ 400
            .||.||.|.|.....:    ..||..|.::                    .::....||||||.:
Human   329 LWWVVLTLTWFLAAGK----KWGHEAIEAH--------------------GSYFHMAAWGLPALK 369

  Fly   401 TSAVIVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNS 465
            |..::..|.|..|||.|.|:|.:....||...|..|:..|.:.||..|::|::.....::|::..
Human   370 TIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKTG 434

  Fly   466 NALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWL---------------G 515
            ...:  ::|::|...    ||:|..:|.:....:::..:||..|:|.|.               |
Human   435 GTNT--EKLEKLMVK----IGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGG 493

  Fly   516 SGDTNTP------LWPFLLRAFMELMLGICCFAWVLGPSI----STLYKRQVSNGKMVKHTSAGA 570
            ..|.:.|      :..|:|:.||.|::||....||.....    .:|..|:::.|:  ....|..
Human   494 RRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKIAAGR--ARAKACR 556

  Fly   571 ATGHLDGHSSSRGSHAACNSTVVSYHSVRT 600
            |.|     |..||:|....:..|..|..:|
Human   557 APG-----SYGRGTHCHYKAPTVVLHMTKT 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	58/131 (44%)
		7tmF_Frizzled_SMO	222..557	CDD:320089	91/372 (24%)
		TM helix 1	231..256	CDD:320089	4/24 (17%)
		TM helix 2	268..289	CDD:320089	7/32 (22%)
		TM helix 3	321..347	CDD:320089	15/25 (60%)
		TM helix 4	388..404	CDD:320089	7/15 (47%)
		TM helix 5	426..455	CDD:320089	9/28 (32%)
		TM helix 6	481..508	CDD:320089	6/26 (23%)
		TM helix 7	519..544	CDD:320089	8/30 (27%)
FZD9	NP_003499.1	CRD_FZ	35..161	CDD:470581	55/124 (44%)
		Required for Wnt-activated receptor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8	58..172		48/116 (41%)
		7tmF_FZD9	221..542	CDD:320164	90/369 (24%)
		TM helix 1	230..255	CDD:320164	5/39 (13%)
		TM helix 2	264..285	CDD:320164	4/20 (20%)
		TM helix 3	314..340	CDD:320164	15/25 (60%)
		TM helix 4	357..373	CDD:320164	7/15 (47%)
		TM helix 5	395..425	CDD:320164	9/29 (31%)
		TM helix 6	444..471	CDD:320164	7/30 (23%)
		TM helix 7	503..528	CDD:320164	7/24 (29%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	532..537		0/4 (0%)
		Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8	554..591		10/33 (30%)