DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and FZD9

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_003499.1	Gene:	FZD9 / 8326	HGNCID:	4047	Length:	591	Species:	Homo sapiens

Alignment Length:	619	Identity:	179/619 - (28%)
Similarity:	273/619 - (44%)	Gaps:	140/619 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPK 110
            |:.:.|.|||.||||.|.||||:|:..|.:....|..||||::|.|.|.|:.|||:.|.||||.:
Human    39 CQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQ 103

  Fly   111 --APVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCME-------GPGE 166
              .|:.|   ||.:||..|:||.|:::.|.|.||.:|||.:.|..|:...:|||       ||.|
Human   104 VSTPIPA---CRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPAE 165

  Fly   167 LHQPQQEQDLYGL------------PGQGIPGGLGGKLPMDCSGLAKS---HLYVRLPRSGRCAP 216
            .|:        ||            ||...||. ||      ||..::   ..||...||  |||
Human   166 PHK--------GLGMLPVAPRPARPPGDLGPGA-GG------SGTCENPEKFQYVEKSRS--CAP 213

  Fly   217 LC--EADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSP------ 273
            .|  ..::.::..:|..|.:|::.|          :.:|..::     |....:.||.|
Human   214 RCGPGVEVFWSRRDKDFALVWMAVW----------SALCFFST-----AFTVLTFLLEPHRFQYP 263

  Fly   274 ------LIWCHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTV-DGLSNASCASVFLMRYYFG 331
                  |..|:|:.:|.:.:|.:.|....||..:..|    |..: :||.|..|..|||:.||||
Human   264 ERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGA----LYVIQEGLENTGCTLVFLLLYYFG 324

  Fly   332 MAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGL 396
            ||:..||.||.|.|.....:    ..||..|.::                    .::....||||
Human   325 MASSLWWVVLTLTWFLAAGK----KWGHEAIEAH--------------------GSYFHMAAWGL 365

  Fly   397 PAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEI 461
            ||.:|..::..|.|..|||.|.|:|.:....||...|..|:..|.:.||..|::|::.....::|
Human   366 PALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKI 430

  Fly   462 LRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWL------------ 514
            ::.....:  ::|::|...    ||:|..:|.:....:::..:||..|:|.|.
Human   431 MKTGGTNT--EKLEKLMVK----IGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAA 489

  Fly   515 ---GSGDTNTP------LWPFLLRAFMELMLGICCFAWVLGPSI----STLYKRQVSNGKMVKHT 566
               |..|.:.|      :..|:|:.||.|::||....||.....    .:|..|:::.|:  ...
Human   490 GPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKIAAGR--ARA 552

  Fly   567 SAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRT 600
            .|..|.|     |..||:|....:..|..|..:|
Human   553 KACRAPG-----SYGRGTHCHYKAPTVVLHMTKT 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	58/131 (44%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	87/354 (25%)
FZD9	NP_003499.1	TM helix 1	230..255	CDD:320164	5/39 (13%)
		TM helix 2	264..285	CDD:320164	4/20 (20%)
		TM helix 3	314..340	CDD:320164	15/25 (60%)
		TM helix 4	357..373	CDD:320164	7/15 (47%)
		TM helix 5	395..425	CDD:320164	9/29 (31%)
		TM helix 6	444..471	CDD:320164	7/30 (23%)
		TM helix 7	503..528	CDD:320164	7/24 (29%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	532..537		0/4 (0%)
		Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250\|UniProtKB:Q8K4C8	554..591		10/33 (30%)
		CRD_FZ	35..161	CDD:321937	55/124 (44%)
		Required for Wnt-activated receptor activity. /evidence=ECO:0000250\|UniProtKB:Q8K4C8	58..172		50/124 (40%)
		7tmF_FZD9	221..542	CDD:320164	90/369 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820